Nitric Oxide Flashcards
Which of the following is true regarding nitric oxide?
(a) All isoforms are inducible
(b) Rate of production determined by substrate availability
(c) Bacterial polysaccharides inhibit synthesis
(d) Not found in neuronal tissue
(e) Formed from L-arginine
(e) Formed from L-arginine
Which of the following is false regarding nitric oxide?
(a) Accelerates atherogenesis
(b) Increased production in septic shock
(c) Cantrols regional blood flow
(d) Has physiological role in defense against infection
(e) Limits platelet aggregation
(a) Accelerates atherogenesis
Which of the following statements concerning nitrate mechanism of action is true?
(a) Therapeutically active agents in this group are capable of releasing nitric oxide (NO) in to vascular smooth muscle target tissues.
(b) Nitric oxide (NO) is an effective activator of soluble guanylyl cyclase and probably acts mainly through this mechanism.
(c) Nitrates useful in angina decrease myocardial oxygen requirement (by decreasing the determinations of oxygen demand) and increase myocardial oxygen delivery (by reversing coronary arterial spasm).
(d) All of the above.
(d) All of the above.
