NIPS

Question 1

The focus of non-invasive prenatal screening is on identifying differences in the number and/or structure of chromosomes.

Answer 1

TRUE

Question 2

Typical human cells contain 46 pairs of chromosomes.

Answer 2

FALSE

Question 3

The purpose of prenatal screening is not prevention, but rather to provide actionable information to families seeking insight into the health of their pregnancy.

Answer 3

TRUE

Question 4

In order to obtain a true diagnosis for a pregnancy, a procedure such as amniocentesis or chorionic villus sampling (CVS) must be performed.

Answer 4

TRUE

Question 5

Non-invasive prenatal screening revolutionized screening for aneuploidies when it became clinically available in 2018.

Answer 5

FALSE

Question 6

Non-invasive prenatal screening is the only screening modality that can provide information on sex chromosome aneuploidies.

Answer 6

TRUE

Question 7

NIPS has the lowest false-positive rate of all screening modalities.

Answer 7

TRUE

Question 8

All women should be offered the option of aneuploidy screening or diagnostic testing for fetal genetic disorders, regardless of maternal age.

Answer 8

TRUE

Question 9

Guidelines recommend that testing for microdeletion syndromes be routinely performed via NIPS.

Answer 9

FALSE

Question 10

The Prequel Prenatal Screen utilizes a SNP-based platform for testing.

Answer 10

FALSE

Question 11

The resolution of a no-call or failed NIPS result can delay a patient receiving valuable information by 3-6 weeks.

Answer 11

TRUE

Question 12

PPV is influenced by maternal age and paternal age.

Answer 12

FALSE ( maternal age & gestational age)

Question 13

For clarity, PPV is included on the report as a percentage only.

Answer 13

FALSE

Question 14

You might have to help a provider draw the connection between PPV and the risks reported by older methods of screening such as maternal serum screening.

Answer 14

TRUE ?

Question 15

When managing competitive discussions, it is always important to redirect the conversation back to Prelude.

Answer 15

TRUE

Question 16

Two NIPS labs that offer an alternative testing platform are Natera and Ariosa/Roche.

Answer 16

TRUE

Question 17

Two NIPS labs that offer fee-forgiveness or max-out-of-pocket programs are Myriad Women’s Health and LabCorp.

Answer 17

FALSE (progenity and harmony)

Question 18

One major differentiator in the NIPS space is the calculation and reporting of a personalized positive predictive value and residual risk.

Answer 18

TRUE

Question 19

Compared with WGS platforms, SNP-based testing has a lower failure rate.

Answer 19

FALSE

Question 20

SNP-based testing can differentiate maternal and fetal DNA.

Answer 20

FALSE

Question 21

Zygosity determines if twins are identical or fraternal.

Answer 21

TRUE

Question 22

With Prequel, our focus is on market development rather than competitive selling.

Answer 22

FALSE

Question 23

A common scenario you will find with customers is that many offer NIPS only to “high-risk” patients.

Answer 23

TRUE

Question 24

The Prequel messaging pillar of “Reliable Results the First Time” is supported by our low test failure rate and our clinical experience poster.

Answer 24

TRUE

Question 25

Compared with SNP technology, our WGS testing provides fewer test failures, fewer false negatives, and leads to fewer invasive procedures.

Answer 25

TRUE

Question 26

Prequel is an effective NIPS choice for patients with low fetal fraction, consanguineous couples, and twin pregnancies.

Answer 26

TRUE

Question 27

Guidelines from SMFM, ACOG, and ACMG are expanding to include testing for all patients.

Answer 27

TRUE

Question 28

92% of the consults performed by our genetic counselors related to Prequel results are for patients whose pregnancies have tested negative.

Answer 28

True

Question 29

Price estimates are particularly important for the general OB population, including “average-risk” patients.

Answer 29

TRUE

Question 30

The term autosome refers to?

Answer 30

Chromosome 1-22

Question 31

What is the purpose of a screening test?

Answer 31

Identify patients at increased risk