NINCDS-ADRDA Criteria

Question 1

what are the criteria for diagnosis?

Answer 1

dementia as established by mental status exam
at least two domains of cognitive defects
progressive cognitive decline
negative delirium
onset between 45 and 90
NBE

Question 2

what are the domains of cognitive defects?

Answer 2

short term memory loss (amnesia)
language deficits (aphasia)
perceptual deficits (agnosia)
learned motor skills (apraxia)
executive function 
behavior

Question 3

what are the requirements for probable alzheimers?

Answer 3

dementia with an atypical course with absence of a better explanation
or
presence of another disease process capable of causing dementia but thought to not be the cause of the dementia in this case
or
single domain progressive cognitive decline, thought to be due to alz

Question 4

how do you make the diagnosis definite?

Answer 4

histopathological evidence

Question 5

what are features that make the diagnosis unlikely?

Answer 5

sudden onset
focal sensorimotor neurological deficits
seizures or gait disorder early in the course of the disease (this is likely something else)