Nikoletta Lecs Flashcards
1
Q
What’s the purpose of dissolution testing?
A
As a quality control
Predict dosage form PK in vivo
2
Q
List 6 physiological conditions that can affect drug dissolution
A
Properties of GI fluids Gastric emptying Intestinal transit time GI motility & hydrodynamic patterns GI enzymes Fasted/fed state
3
Q
What does FaSSGF stand for?
A
Fasted state simulated gastric fluid
4
Q
What does FeSSIF stand for?
A
Fed state simulated intestinal fluid
5
Q
What does FaSSCoF stand for?
A
Fasted state simulated colonic fluid
6
Q
Name four types of dissolution apparatus
A
Rotating basket
Rotating paddle
Reciprocating cylinder bio-dis
Flow-through cell
7
Q
Name two closed system dissolution apparatuses
A
Basket
Paddle
8
Q
Define dissolution
A
The amount of active ingredient in a solid dosage form that is dissolved per unit time under standardised conditions of liquid solid interface, temperature and media composition
