Nikki Kuiper Flashcards

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0
Q

What are the components of cartilage?

A
Chondrocytes 3%
Collagens 15%
Proteoglycans 10%
Water 70-80%
Other 3%
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1
Q

What are the three main cartilage types?

A

Elastic
Fibrocartilage
Hyaline (articular)

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2
Q

What is the function of Chondrocytes?

A

To synthesise and degrade matrix

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3
Q

What are proteoglycans?

A

They have a protein core with glycosaminoglycans attached

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4
Q

What is the function of a proteoglycan aggregate?

A

It provides tissue hydration and compressibility

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5
Q

What’s the function of collagen?

A

Tensile strength and durability

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6
Q

Where would you find elastic cartilage?

And what is its function?

A

Ear
Larynx
Epiglottis
It provides elasticity and maintains shape

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7
Q

Where would you find fibrocartilage?

And what’s its function?

A

Intervertebral discs
Menisci
It’s a shock absorber, resists compression and provides durability

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8
Q

Where would you find hyaline cartilage?

What’s its function?

A
Nose
Trachea
Fetal skeleton
Costal cartilage
It's a shock absorber tougher than fibrocartilage
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9
Q

Where would you find hyaline articular cartilage and what’s its function?

A

In articulating joints

It has a smooth articulating surface and distributes load evenly to underlying bone

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10
Q

What are the two types of bone?

A

Compact (hard) outer layer

Cancellous (spongy) inner layer

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11
Q

What are the three bone cell types and what are there functions?

A

Osteoclasts- resorb it
Osteoblasts- build it
Osteocytes- maintain it

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12
Q

Without minerals what happens to bone?

A

It bends

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13
Q

Without collagen what happens to bone?

A

It breaks

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14
Q

What are the three main types of joints?

A

Fibrous
Cartilaginous
Synovial

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15
Q

What type of joints are sutures in the skull?

A

Fibrous

16
Q

Cartilaginous joints are split into……

A

Primary and secondary

17
Q

Give an example of a primary cartilaginous joint?

A

Sternum- cartilage- ribs

18
Q

With ageing what happens to bone?

A

Reduced amount of tissue and osteoblast activity

Becomes fragile

19
Q

With ageing what happens to cartilage?

A

Decreased swelling pressure of proteoglycans
Decreased responsiveness of Chondrocytes
Loss of shock absorbing properties

20
Q

What is OA?

A

A disorder of synovial joints
Gradual loss of cartilage
Bony spurs (osteophytes)
Boney cysts

21
Q

What is the function of the leptin hormone?

A

To regulate appetite and metabolism