Nickolskys sign Flashcards by Sian John | Brainscape

Q

What is Nikolskys sign?

A

Dislodgement of intact superficial epidermis by shearing force
Indicating plane of cleavage in skin at dermal -epidermal junction which induces a bulla

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Q

What are the clinical signs of Nikolskys sign?

A

Exfoliation of outermost layer by slight rubbing of skin

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Q

What conditions is a positive Nikolsky sign present in?

A

MMP
PV
PFoliaceus
Stevens-Johnson sydrome

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Q

How do you elicit Nikolskys sign?

A

Apply lateral pressure with thumbs or fingertips on peri lesional skin
Results in shearing force that dislodges upper layers of epidermis from lower epidermis
Positive if upper epidermis separates from lower
Helps distinguish pemphigus and bullous pemphigoid

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A

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