Nichols Bone and Cartilage tumors

Question 1

what q do you ask of tumors

Answer 1

age, sex, location, radiographic appearance

Question 2

Answer 2

chondroma lots of chondrocytes packed by periph in pink ground substance

Question 3

Answer 3

chondroma

Question 4

osteogenic sarcoma is how many/

Answer 4

20% of primary bone cancers is osteogenic sarcoma

MOST COMMON primary bone tumor

Question 5

who gets osteogenic sarcoma

Answer 5

75% are <20 yo

samller peak in elderly – Paget, irradiation can become this

Question 6

where is osteosarcoma

Answer 6

knee

metaphysis of long bones

Question 7

genes in osteosarcoma

Answer 7

Rb

MDM2

Question 8

clinical symp of osteosarcoma

Answer 8

painful, progressively enlarging

fractures

Question 9

in sporadic osteosarcoma, the majority of osteosarcomas, Rb mut?

Answer 9

NO. just if retinoblastoma.

instead it would have MDM2 overexpression

Question 10

Answer 10

chondrosarcoma at knee invading tibia do NOT resect joint spaces

Question 11

Answer 11

chondrosarcoma

big nuc, mitoses

Question 12

Answer 12

chondrosarcoma cellular mimic normal chondrocytes but big nuc and mitoses

Question 13

Answer 13

enchondroma

scalloped edges

Question 14

Answer 14

ewing sarcoma aka pnet w small round blue clles glycogen rich cytoplasm can vacuolate almsot. sheets of cells

Question 15

Answer 15

ewing sarcoma in endopyysis of long bone

Question 16

Answer 16

giant cell tumor of bone hazy mass destroyign distal femur

Question 17

what is diagnostic of osteosarcoma?

Answer 17

MALIGNANT OSTEOID. aka formation of bone by tumor cells. see fine, lacelike architecture or broad sheets

Question 18

Answer 18

reactive bone and osteoid

Question 19

Answer 19

homer wright rosettes sugg neural diff in a pnet ewing sarcoma

Question 20

Answer 20

osteochondroma prominent cartilage cap

Question 21

Answer 21

osteochondroma

Question 22

Answer 22

osteoid osteoma random trabec of woven bone rimmed by a layer of osteoblasts congested caps

Question 23

osteosarcoma goes where?

Answer 23

LUNG

Question 24

Answer 24

osteosarcoma

Question 25

Answer 25

osteosarcoma

codman triangle

Question 26

Answer 26

osteosarcoma invades bone and prod poor spicules in hypercell matrix of osteoid and pleomorph malig cells

Question 27

what is codman triangle

Answer 27

osteosarcoma

lifted periosteum forming triangular shell of reactive bone on periph. characteristic but not pathognomonic

Question 28

Answer 28

osteosarcoma making cartilage. tumor cells turning pink

Question 29

Answer 29

osteosarcoma codman triangle and bone pushing out

Question 30

Answer 30

osteosarcoma w varying tumor cell sizes and hyperchrom nuc weird giant cells and mitoses

Question 31

joint space

Answer 31

respected by benign tumors

but malignant tumors invade

Question 32

Answer 32

osteosarcoma

Question 33

Answer 33

pnet aka ewing sarcoma

“onion skin”

Question 34

describe ewing sarcoma

Answer 34

medulla of diaphysis of long bone

onion skin appearance bc layers of reactive periosteum and neoplasm

Question 35

who gets ewing sarcomas

Answer 35

often younger (20 yo for example)

Question 36

microscopic apperance of ewing

Answer 36

small blue cells

not many mitoses

glycogen rich cytoplasm

structureless sheets of cells

prominent necrosis in geographic pattern

Question 37

Homer Wright rosette

Answer 37

dark blue tumor cells w surrounding pink fibrillar material like neuropil

Ewing Sarcoma

Question 38

commonest neoplasm in bone is?

Answer 38

METASTASIS

renal cell carcinoma

breast cancer

lung cancer

etc