Newborn Male Circumcision Flashcards
What are the historical medical benefits of male circumcision?
- Ease of genital hygiene
- Diminished risk of disease
- Avoidance of circumcision later in life
What is the current Canadian average rate of circumcision?
32%
What is the usual developmental pattern of retractile foreskin?
- In newborns: inner foreskin and glans adhere to one another
- 6 years of age: 50% boys can retract their foreskin
- 17 years of age: 95% boys can retract their foreskin
What are the potential benefits of circumcision?
- Phimosis treatment
- UTI reduction
- STI reduction
Define phimosis
- Scarring and thickening of the foreskin that prevents retraction back over the glans
- Secondary to recurrent infections, inflammation or lichen sclerosis
- Not the same as normal nonretractile foreskin
Define posthitis and balanoposthitis
- Posthitis: inflammation or infection of the foreskin
- Balanoposthitis: inflammation or infection of the foreskin in association with the glans
What is the incidence of posthitis and balanoposthitis in uncircumcised boys?
- 1-4%
What is the definition and incidence of paraphimosis?
- Definition: foreskin becomes trapped behind the glans
- Incidence: 0.5%
What percentage of boys will need cicrumcision befoer puberty and what is the most common indication for the same?
- 0.8-1.6%
- Indicated for treatment of phimosis
What is the first line medical treatment for phimosis?
- Application of a topical steroid BID to the foreskin with gentle traction
- Serves to thin skin and release adhesions
- Foreskin becomes retractile in 80% with no need for circumcision
What steroid preparations have been used to treat phimosis?
- Betamethasone 0.05-0.1%
- Triamcinolone 0.1%
- Mometasone furoate 0.1%
What role does the preputial sac play in UTI development in male infants?
- Provides an environment for colonization of the urethra with uropathogenic organisms
What is the incidence of UTI in male infants in the first month of age?
1%
What impact does circumcision have on UTI?
- 90% reduction in UTI in circumcised male infants
Compare prevalence of UTI in febrile infants < 3 months of age
- Females 7.5%
- Circumcised males: 2.4%
- Uncircumcised males: 20.1%
What is the NNT with circumcision to prevent one UTI?
111-125 normal infant boys would need to be circumcised at birth to prevent one UTI
What is the NNTto prevent one UTI for males with recurrent UTI or underlying GU anomalies?
4 boys would need to be circumcised to prevent one UTI
What is a confounding factor leading to overdiagnosis of UTI in uncircumcised males?
- Contaminated urine samples are more common in uncircumcised boys
- Therefore NNT can be considerably higher in reality than current estimates
What percentage of UTI leads to DMSA-detectable renal scarring?
15%
What is the long term impact of renal scarring?
- Theoretically scarring could have an impact on long term renal function and cause HTN
- No evidence for this association
- Most experts believe UTIs in children with normal kidneys do not result in long term sequelae
Why could uncircumcised men be at higher risk for HIV?
- Inner surface of foreskin rich in Langerhans and other HIV target cells which are exposed to infection during intercourse
What is the evidence that circumcision decreases HIV transmission?
- 3 large RCTs involving men and teen boys in Uganda, South Africa and Kenya
- Decrease in new HIV infection by 50-60% in circumcised male participants
- Unclear if these conclusions hold true in other populations with lower HIV seroprevalence and where HIV is more likely to be contracted via IVDU and MSM
What were the results of the CDC analysis of cost efficacy of newborn circumcision in reducing the lifetime risk of HIV?
- Cost savings in both Hispanic and Black males
- NNT to prevent one HIV infection in white males is 1231
- NNT to prevent one HIV infection in black males is 65
- Average NNT = 298
- Model did not account for cost of complications in circumcision
- RIsk of men overestimating protective effect of circumcision and not using safe sex practices
What are new cases of HIV attributed to in Canada?
- 46% MSM
- 13.7% IVDU
- Heterosexual transmission 20.3%
Compare HIV transmission in aboriginal compared to non aboriginal populations
Rate of new cases in aboriginal population is 3.5 times higher than non aboriginal population
What effect does circumcision have on other STIs besides HIV?
- Lower rates of HSV-2 seroconversion
- Lower rates of HPV acquisition
- Not protective against gonorrhea or chlamydia
- Female partners of circumcised men with lower prevalence of
- Trichomonas (0.52)
- Bacterial vaginosis (0.60)
- Genital ulcer disease (0.78)
What is the cervical cancer risk in female partners of circumcised men?
Reduced with ORs ranging from 0.18-1.61 depending on the sexual behavioural risk level of their partner
What is the incidence of cervical cancer in Canada?
9-17/100,000
What is the incidence of penile cancer in develoepd countries?
1/100,000
What is the strongest associated RF for squamous cell carcinoma of the penis?
- Phimosis
- OR 11.4
- Underscores importance of genital hygiene and of identifying and treating cases of phimosis and residual nonretractile foreskin in all males
- Also a strong association between HPV infection and penile cancer regardless of circumcision status
List potential risks of circumcision
- Procedural pain - altered response to later vaccinations with higher demonstrated pain scores
- Minor bleeding
- Local infection
- Unsatisfactory cosmetic outcome
List severe complications of circumcision
- Partial amputation of the penis
- Death from hemorrhage or sepsis
What is the median complication rate for circumcision in infants and older children?
- Neonates/infants: 1.5%
- Childhood: 6%
What is the most common late complication of circumcision?
- Meatal stenosis
- 2-10%
- May require surgical dilation
How to prevent meatal stenosis?
- Applying petroleum jelly to the glans for up to 6 months following circumcision
- Partial re-adherence of penile skin to glans is common, usually resolves spontaneously by puberty but can also benefit from topical steroids
What is the effect of circumcision on sexual function or satisfaction?
- No negative impact on sexual function or satisfaction
- Some literature reports males not happy with cosmesis but no specific data to quantify this
What are the containdications to circumcision?
- Hypospadias
- Bleeding diathesis