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Question 1

Dukes Criteria
- Major
- Minor

Answer 1

Major:
1. blood cultures positive for typical microorganism
2. Echo showing valvular vegetation

Minor:
1. predisposing cardiac lesion or IVDU
2. Temperature >38
3. Embolic phenomena
4. Immunologic phenomena (GN etc.)
5. Positive culture not meeting major criteria

Question 2

Dukes
Cut off for Definite IE
Cut off for possible IE

Answer 2

Definite: 2 major OR 1 major + 3 minor
Possible: 1 major and 1 minor OR 3 minor

Question 3

Jones Criteria
- Major
- Minor

Answer 3

Major:
1. carditis, polyarthritis, chorea, erythema marginatum, subcutaneous nodules

Minor:
1. polyarthralgia, fever (>38.5), ESR (>30 for high risk population, >60 for low risk population), prolonged PR interval

Question 4

Rheumatic fever diagnosis
- initial ARF

Answer 4

2 major manifesations
or
1 major and 2 minor

Question 5

ARF treatment

Answer 5

Benzathine benzyl penicillin 1.2 million units IM

Question 6

ARF prophylaxis
- things that dictate duration of treatment

Answer 6

Possible vs. probable vs. definite
Cardiac involvement or not
Severity of rheumatic heart disease

Question 7

Duration of prophylaxis for
Mild RHD
Moderate RHD
Severe RHD

Answer 7

mild - 10 years for until 21
moderate - 10 years or until 35
severe - 10 years or until age 40

Question 8

Brudgada
- channel involved
- mode of inheritance

Answer 8

SCN5A and SCN10A
Autosomal dominant, variable penetrance

Question 9

Long-QT common genes
Type 1
Type 2
Type 3

Answer 9

1- KCNQ1
2 - KCNH2
3 - SCN5A