neutrophils and phagocytosis Flashcards
what are the best phagocytes
netrophils
how does netrophils deafend the body?
they englf microbes and kill them by producing reactive species
what are the reactive species?
superoxide ion o2-
hydrogen predoxide h2o2
nitric oxide no
what enzyme does the neutrophils have?
myeloperoxidase the prodces cio- or hypcholirte and its very efficinetly kils pathagones
whats attracts the neutrophils ?
interlukin 8
whats IL-8?
its a chemokine and it attracts netrophils to the site of the infection
hoes does tuberculsis avoid death?
it doesnt fuse with lysosomes
hoes does listeria avoid death
its escapes from phagosome into cytoplasm
what are the 2 ways to sense the microbe ?
1- fc receptor
2-complement receptor
what is opsonin
its a lg antibodi and its bind to a bacteria, and helps with phagocytosis.
what is complent protein and how does it work?
its work like the antibody and its an opsonin, wich coplent protien c3b binds to bacteria, then complent receptor binds to c3b+bacteria
what are the toll recpetor that are presnt in the cell membrane?
TLR4, TLR2 , TLr5
toll receptor prresent in the cytoplasm?
TLR3, TLR9, TLR7
What does TLR3 senes?
double standerd RNA of viruses
What does TL7 sense?
single stranded RNA of viruses.
