Neurotransmitters, Changes in Disease, and Sites of Synthesis EC

Question 1

NE (location of synthesis, changes in disease)

Answer 1

Synthesized in Locus ceruleus and Reticular formation

Increased in anxiety
Decreased in depression

Question 2

Dopamine (location of synthesis, changes in disease)

Answer 2

Synthesized in Ventral tegmentum and SNc

Increased in schizophrenia
Decreased in depression and Parkinsons

Question 3

5-HT (location of synthesis, changes in disease)

Answer 3

Synthesized in Raphe nucleus

Decreased in depression and anxiety

Question 4

ACh (location and synthesis, changes in disease)

Answer 4

Synthesized in Basal nucleus of Meynert

Increased in REM sleep
Decreased in Alzheimer’s and Huntington’s

Question 5

GABA (location and synthesis, changes in disease)

Answer 5

Synthesized in Nucleus accumbens

Decreased in anxiety and Huntington’s

Question 6

Neurotransmitter changes in anxiety

Answer 6

Increased NE

Decreased 5-HT and GABA

Question 7

Neurotransmitter changes in depression

Answer 7

Decreased NE, Dopamine, 5-HT

Question 8

Neurotransmitter changes in Schizophrenia

Answer 8

Increased Dopamine

Question 9

Neurotransmitter changes in Parkinson’s

Answer 9

Decreased Dopamine

Question 10

Neurotransmitter changes in Alzheimer’s

Answer 10

Decreased ACh

Question 11

Neurotransmitter changes in Huntington’s

Answer 11

Decreased ACh and GABA