Neurotransmitters Flashcards
DA release in what structure represents common final event assoc w reinforcing effects of opiates, cocaine, amphetamines, nicotine, PCP, and alcohol?
NUCLEUS ACCUMBENS
Role of glycine at NMDA receptor
OBLIGATE COAGONIST
Which neurotransmitter system is the last to mature in the CNS of children and adolescents?
CHOLINERGIC
A compound that increases muscle mass by increasing episodic secretion of GH
GAMMA HYDROXYLBUTYRATE
Highest concentration of 5HT producing cells in brain?
RAPHE NUCLEI
DA and what else regulates reward circuitry
GABA
Neuroimaging technology most useful in studying connectivity pathways:
SINGLE PHOTON EMISSION CT SCAN
What area of the body has the most serotonin?
GI TRACT
What neurotransmitter has been associated with anxiety?
NOREPINEPHRINE
Positive allosteric modulators of neurotransmitter-gated, multimeric ion channels do what?
INCREASE PROBABILITY OF OPENING IN PRESENCE OF A LIGAND
Where are the major clusters of cell bodies containing serotonin in brain?
RAPHE NUCLEUS IN THE BRAIN STEM
Principal mechanism of termination of synaptic activity of dopamine in prefrontal cortex?
DIFFUSION
Opiates inhibit Camp dependent protein phosphorylation in:
LOCUS CERULEUS
Neurotransmitter maintains consistent levels with age:
SEROTONIN
Which neurotransmitters are reduced in quantity, uptake and turnover is spasticity?
GLYCINE & GABA
The cognitive enhancement associated with experimental D-cycloserine treatment in pt’s with schizophrenia has been attributed to enhancement of NMDA receptor activity by which of the following neurotransmitters?
GLYCINE
In addiction, dopaminergic neurons project to nucleus accumbens. Cell bodies of these neurons reside in which area of brain?
VENTRAL TEGMENTAL AREA
Which neurotransmitter is predominantly inhibitory?
GLYCINE
Neurotransmitter assoc w/ reward & reinforcement in nicotine dependence
DOPAMINE
Prostaglandin D2 increases extracellular levels of…
ADENOSINE
Which is a retrograde neurotransmitter?
ENDOCANNABINOIDS
Characteristics of Ach receptors in cerebral cortex
BOTH INHIBITORY AND EXCITATORY
Neurohormone for social bonding
OXYTOCIN
Neurotransmitter from responsible for rewarding nature of drug abuse
DOPAMINE