Neurotransmitters Flashcards
Classical NTs
Small, rapid acting, ex: Ach, Dopamine -ATP is odd one
Neuropeptides
Large, slow-acting, may act as co-transmitters (with a classical NT)
ATP NT classification
NT in brain-classical
Unconventional NT
Break rules of things considered to be NTs (stored and released from vesicles via exocytosis)
AMPA receptors
Very fast-sensory and cognition-let sodium in
NMDA receptors
critical in memory-little slower than AMPA but long lasting
-let Na and Ca in
NMDA and stroke
Overstimulated –> let in too much Ca –> kill neurons
GABA
Main receptor in the brain for inhibition
GABA a receptors
Cl channels
These are ion channels that let chloride in. Going to hyperpolarize the and make the cell more negative (makes it harder to have an action potential).
GABA b receptors
open K channels and hyperpolarize the cell (make it more negative)) and is slower than GABA a
Glycine
Main inhibitory transmitter in the spinal cord-lets in Cl
Glutamate
Very fast and used for excitatory pathways
If inhibited CNS would shut down
Norepinephrine
Monoamine which acts on alpha and beta receptors which are coupled to g-proteins and have broad actions