neurotransmitters

Question 1

neurotransmitter

Answer 1

1. synthesised in presynaptic neuron
2. is present in presynaptic terminal and when released act on presynaptic target or organ
3. if exogenously dilevered, it will make the same effect if done endogenously
4. some mechanism to remove it from synaptic cleft

normally 1:1 communication ( 1 neurotransmitter afffect 1 neuron)
neuromodulatots affect groups of neurons

Question 2

synaptic transmission

Answer 2

1. synthesis and stirage of neurotransmitter in presynaptic neuron
2. release of neurotransmitter by presynaptic neuron into synaptic cleft
3. intereact with neurotransmitter targets (receptors/ion channel/transporters)
4. removal of neurotransmitter ie reuptake

can happen on presynaptic membrane autoreception. bind back to self - normally inhibit as negative feedback loop

Question 3

subtype of neurotransmitter

Answer 3

small molecule: short amino acid (8-9). low molecular weight, small vesicles approx. 40nm in diameter (5-10 copies of neurotransmitter)

neuroactive peptides: long chains (80-90), low molecular weight, large vesicles approx. 70-250nm in diameter

Question 4

small molecule transmitter

Answer 4

several classes
many act as neuromodulators