Neurotransmitters

Question 1

What are the 3 classes of neurotransmitters?

Answer 1

small molecule transmitters, peptide transmitters, and transmitter gasses.

Question 2

Which produce faster post synaptic responses, Neuropeptides or small molecule transmitter?

Answer 2

Small molecule transmitters

Question 3

What enzyme in the synaptic cleft breaks down ACh rapidly and what part of it is reuse to make more Acetylcholine?

Answer 3

Acetylcholinesterase, and choline.

Question 4

What happens when ACh binds to acetycholine receptors?

Answer 4

Sodium enter, then calcium is release and produce muscle contraction.

Question 5

What are some effect of ACh in the brain?

Answer 5

Its active in maintaining waking electroencephalographic pattern of the cortex, thought to play a role in memory by maintaining neuron excitability. Decrease of ACh are thought to be related to alzheimer’s disease.

Question 6

What is rate-limiting factor?

Answer 6

Any enzymes that is in limited supply, thus restricting the paced at which a chemical can be synthesized.

Question 7

Give me the steps that happens in dopaminergic synapse?

Answer 7

Once dopamine is released. Reuptake by dopamine transporter (DAT). Bind to auto-receptors. monoamine oxidase (MAO) and catechol O-methyltransferase (COMT).Bind to metabotropic receptors (D1-5).

Question 8

Give me two pathways of dopaminergic system?

Answer 8

Nigrostriatial and mesolimbic pathways.