Neurotransmitters Flashcards

1
Q

List the two inhibitory neurotransmitters in the nervous system.

A
  1. GABA
  2. Glycine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

List some (8) excitatory neurotransmitters found in the nervous system.

A
  1. Acetylcholine (Ach)
  2. Aspartate
  3. Adrenaline
  4. Dopamine
  5. Histamine
  6. Glutamate
  7. Noradrenaline
  8. Serotonin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Glutamate is known as…

A

Amino acids that are always excitatory?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the general main role of Dopamine?

A

Modifying somatic movements and happiness, emotion & behaviour are regulated by dopamine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the amino acid neurotransmitters in the nervous system?

A

Acetylcholine, Glutamate, Aspartate, GABA & Glycine are amino acid neurotransmitters.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

All of the drugs used in the stalling of progression of dementia (alztheimers disease) act on which type of neurotransmitters?

A

Amino acid neurotransmitters.
Of the 4 drugs 3 affect Acetylcholine pathways and the other effects Glutamate.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the monoamine neurotransmitters (4) in the nervous system?

A

Adrenaline,
Noradrenaline,
Serotonin,
Dopamine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Are neuorpeptides such as substance p and endorphines considered neurotransmitter?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the two nuclei and pathways effected in the cholinergic hypothesis of Alzheimers Disease?

A

Ach neuron nuclei implicated in Alzheimers Disease.
1. The Nucleus Basalis (nucleus > cortex).
2. The Septohippocampal nucleus (Septal area > via hypothalamus > hippocampus). (*key in learning and memory).
3. Pedunculopontine / lateraodorsal tegmental nucleus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What three drugs are used to treat Alzheimer’s Disease which act on Ach Pathways.

A
  1. Donepezil
  2. Rivastigmine
  3. Galantamine

These drugs are AchE inhibitors that can cross the blood brain barrier thus they increase the amount of Ach in these neurons of the Basalis nucleus and the septohippocampal nucleus by preventing AchE from degrading the neurotransmitter Ach.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

There are four drugs used to treat Alzheimer’s Disease. Three are AchE inhibitors and the last is an NMDA antagonist. What is it called and how does it work?

A

Memantine is a NMDA (glutamate) receptor antagonist. Glutamate is a Amino Acid that is believed to be implicated in neuronal death in Alzheimer’s Disease thus it is theorised blocking Glutamate levels prevents neuronal cell loss.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the MOA of botulinum toxin (Botox)?

A

Botox inhibits SNARE proteins from facilitating exocytosis of Ach from cholinergic neuron terminals. Because Botox has a very high affinity for cholinergic SNARE proteins. This prevents the normal SNARE protein facilitated exocytosis of Ach from cholinergic neurons thus causing a cholinergic deficit and therefore paralysis at the site of injection.

In the absence of ACH release from cholinergic neurons there is no Ach to bind to and stimulate skeletal muscle ligand gated channels, which would induce depolarisation > contraction of skeletal muscles.

Remember when Ca2+ enters the terminal button via the voltage gated ion chanel it is calcium that interacts with the SNARE proteins to promote transport of the vesicle to the synaptic cleft for fustion and exocytosis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Acetylcholine (Ach) works on which types of receptors?

A
  1. Nicotinic (ligand gated ion channel)
    - NN (Ganglia)
    - NM (skeletal Muscle)
  2. Muscarinic receptors (G protein coupled receptors)
    - M1 (Neuronal) -< Gq receptors
    - M2 (Cardiac tissue) -Gi receptors
    - M3 (Glandular tissue) -< Gq receptors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are common uses of Botox?

A

Wrinkle reduction,
Spacity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the different types (3) of G protein coupled receptors?

A
  1. Gs - stimulatory receptors
  2. Gi - inhibitory receptors
  3. Gq - super-stimulatory receptors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Why does a cholinergic deficit lead to dryness of mouth?

A

Muscarinic receptors stimulated by Ach located on glands are Gq super-stimulator receptors). In the absence of / reduced levels of Ach salivary glands are not stimulated and therefore dryness of mouth is experienced.

17
Q

If Dopamine, Adrenaline and Noradrenaline are derived from the same precurser molecule, Tyrosine what makes Dopaminergic and Adrenergic neurons different?

A

Dopaminergic neurons contain only the enzymes:
TH (tyrosine hydroxolase / DDC / Aromatic AADC) which converts Tyrosine > Dopa; and
DOPA decarboxylase which converts DOPA > Dopamine.

Adrenergic neurons contain a further two enzymes:
Dopamine-B-hydroxolase to convert Dopamine > Noradrenaline; and
PENMT (phenylehanolamine-N=methyl transferase) to convert Noradrenaline > Adrenaline.

18
Q

What area of the brain has high amounts of adrenergic neurons?

A

Locus Coerulus

19
Q

What are the names of the main dopaminergic pathways in the CNS?

A
  1. Nigrostriatal (smooth movement)
  2. Mesolimbic (reward system)
  3. Mesocortical (unknown role but inhibition causes ve- symptoms of psychosis)
  4. Tuboinfundibular / tuberohypophyseal (connects hypothalmus to pituitary and increased stimulation reduces prolactin secretion).
20
Q

What does the Nigrostriatal pathway connect?

A

Substantia nigra (houses nuclei of dopaminergic neurons in this pathway) and connects to the > Striatum (caudate and putamen) to regulate out stop go signalling for smooth somatic muscle movements.

21
Q

What is another name for the reward pathway?

A

The mesolimbic pathway

22
Q

What does the mesolimbic pathway connect?

A

VTA (nucleus of the midbrain containing nuclei of dopaminergic neurons in the pathway) >
1. Amygdala
2. Nucleus Acumbens (striatum)
3. Limbic system

23
Q

What does the mesocortical pathway connect?

A

VTA (midbrain nuclei containing dopaminergic neurons) to the prefrontal cortical areas. The role is unknow however inhibition of this pathway leads to ve- symptoms of psychosis such as depression, reduced motivation, reduced skeletal muscle movement.

24
Q

What does the tuberoinfundibular / tuberohypophyseal pathway connect?

A

The hypothalamus to the pituitary gland (dopaminergic pathway) which when stimulated is involved in reducting prolactin secretion.