Neurotansmitters

Question 1

What are the three criteria’s for neurotransmitters

Answer 1

1. Synthesis and storage in presynaptic neuron
2. Released by presynaptic axon terminal
3. When applied, mimics postsynaptic cell response produced by release of neurotransmitter from the presynaptic neuron.

Question 2

What are the three classes of neurotransmitters?

Answer 2

1. Amino acids
2. Amines
3. Peptides

Question 3

How do you study neurotransmitter systems?

Answer 3

1. Immunohistochemistry - localises transmitters and transmitter-synthesising enzymes
2. In situ hybridisation - localises synthesis of protein or peptide to a cell ( detect mRNA)

Question 4

Define microiontophoresis

Answer 4

Assess postsynaptic actions