Neuroplasticity Flashcards

1
Q

A weakly connected network leads to…

a) low plasticity

b) high plasticity

A

b) high plasticity

A weakly connected network leads to high plasticity, i.e. a high susceptibility to change the state of the system.


A strongly connected network leads to low plasticity, i.e. a low susceptibility to change the state of the system.

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2
Q

An unfavourable environment and high plasticity…


a) promotes wellbeing

b) increases vulnerability

A

b) increases vulnerability

High plasticity + unfavourable environment: increases vulnerability.


High plasticity + favourable environment: promotes wellbeing.

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3
Q

An unfavourable environment and low plasticity…


a) slows down improvement

b) prevents worsening

A

b) prevents worsening.

Low plasticity + unfavourable environment:
prevents worsening.

Low plasticity + favourable environment: slows down improvement.

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4
Q

What are 3 types of neuroplasticity?

A
  1. Chemical change

  2. Structural change

  3. Functional change
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5
Q

How can neurogenesis be blocked?

A

Chemotherapy: blocks division of cells

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6
Q

Homeostatic synaptic plasticity requires presence of

a) Calcineurin

b) Protein phosphatase2C

A

a) Calcineurin.

Calcineurin mediates homeostatic synaptic plasticity by regulating the synthesis of retinoiuc acid (Vit. A), which disinhibits AMPA-R translation

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7
Q

Retinoiuc acid (Vit. A), whose synthesis is regulated by Calcineurin in mediating homeostatic synaptic plasticity, disinhibits AMPA-R translation…


a) systemically

b) locally

A

b) locally.

A neuron in the periphery can compensate for input imbalances through local mechanisms, eliminating the need to relay signals back to the nucleus (neuronal DNA).

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8
Q

What is the role of microglia in neuroplasticity?


a) surveillance of microenvironment facility of synapse


b) Inhibiting synaptic remodeling to maintain a fixed neural structure

A

a) surveillance of microenvironment facility of synapse

If synapses are not active anymore, microglias “eat” them, leaving dendroids “naked”

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9
Q

What is NOT a potential inductor of neuroplasticity?


a) ECT

b) MST

c) TMS

d) diet

e) exercise

f) beta-blockers

g) antidepressants
h) ketamine

A

f) beta-blockers

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10
Q

What is the purpose of iPSC-derived neurons on a chip?


a) Modeling human neural cells

b) Generating genetically modified neurons for gene therapy

A

a) Modeling human neural cells.

iPSC-derived neurons on a chip allow the generation of human neural cells from stem cells for studying neural function and disease.

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