Neurophysiology Flashcards
Neurophysiology
The study of electrical and chemical processes in neurons
Ion
An atom or molecule that has acquired an electrical charge by gaining or losing one or more electrons
Anion
A negatively charged ion, such as a protein or chloride ion
Cation
A positively charged ion, such as a potassium or sodium ion
Intracellular Fluid
CYTOPLASM - The watery solution found within cells
Extracellular Fluid
The fluid in the spaces between cells (interstitial fluid) and in the vascular system
Cell Membrane
The lipid bilayer that ensheathes a cell
Lipid Bilayer
The structure of the neuronal cell membrane, which consists of two layers of lipid molecules. Various specialized proteins, such as ion channels and receptors, are embedded within the membrane
Micro-electrode
An especially small electrode used to record electrical potentials from living cells
Resting Membrane Potential
A difference in electrical potential across the membrane of a nerve cell during an inactive period
Millivolt (mV)
A thousandth of a volt
Negative Polarity
A negative electrical-potential difference relative to a reference electrode
Ion Channel
A pore in the cell membrane that permits the passage of certain ions through the membrane when the channel is open
Potassium Ion (K+)
A potassium atom that carries a positive charge because it has lost one electron
Selective Permeability
The property of a membrane that allows some substances to pass through, but not others
Diffusion
The spontaneous spread of molecules of one substance among molecules of another substance until a uniform concentration is achieved
Concentration Gradient
Variation of the concentration of a substance within a region
Sodium-Potassium Pump
The energetically expensive mechanism that pushes sodium ions out of a cell, and potassium ions in
Sodium Ion (NA+)
A sodium atom that carries a positive charge because it has lost one electron
Equilibrium
Here, the state in which the of ions crossing a membrane in one direction is matched by the number crossing in the opposite direction
Electrostatic Pressure
The propensity of charged molecules or ions to move toward areas with the opposite charge
Nernst Equation
An equation predicting the equilibrium potential for a given ion based on the concentrations of the ion on opposite sides of a permeable membrane
Equilibrium Potential
The voltage across a permeable membrane that exactly counteracts the movement of ions from the side with the high concentration to the side with a low concentration
Goldman Equation
An equation predicting the potential difference across a membrane based on the concentrations of ions on the opposite sides of the membrane, as well as its relative permeability to each ion
Calcium Ion (Ca^2+)
A calcium atom that carries a DOUBLE positive charge because it has lost two electrons
Action Potential
The propagated electrical message of a neuron that travels along the axon to the presynaptic axon terminals
Hyper-polarization
An increase the membrane potential (the interior of the neuron becomes even more negative)
Depolarization
A reduction in membrane potential (the interior of the neuron becomes less negative)
Local Potential
An electrical potential that is initiated by stimulation at a specific site, which is a graded response that spreads passively across the cell membrane, decreasing in strength with time and distance
Threshold
The stimulus intensity that is just adequate to trigger an action potential
All-Or-None Property
The fact that the amplitude of the action potential is independent of the magnitude of the stimulus
Afterpotential
The positive or negative change in membrane potential that may follow an action potential
Voltage-Gated Na+ Channel
A Na+ selective channel that opens or closes in response to changes in the voltage of the local membrane potential; it mediates the action potential
Refractory
Referring to transiently inactivated or exhausted axonal membrane
Absolute Refractory Phase
A period of reduced sensitivity during which only strong stimulation produces an action potential
Axon Hillock
A cone-shaped area from which the axon originates out of the cell body. Functionally, the integration zone of the neuron
Conduction Velocity
The speed at which an action potential is propagated along the length of an axon (or section of peripheral nerve)
Node of Ranvier
A gap between successive segments of the myelin sheath where the axon membrane is exposed
Saltatory Conduction
The form of conduction that is characteristic of myelinated axons, in which the action potential jumps from one node of Ranvier to the next
Channelopathy
A genetic abnormality of ion channels, causing a variety of symptoms
Tetrodototoxin (TTX)
A toxin from puffer fish ovaries that blocks the voltage-gated sodium channel, preventing action potential conduction
Saxitoxin (STX)
An animal toxin that blocks sodium channels when applied to the outer surface of the cell membrane
Batrachotoxin
A toxin, secreted by poison arrow frogs, that selectively interferes with Na+ channels
Neurotransmitter
The chemical released from the presynaptic axon terminal that serves as the basis of communication between neurons.
Also called synaptic transmitter, chemical transmitter, or simply transmitter
Postsynaptic Potential
A local potential that is initiated by stimulation at a synapse, can vary in amplitude, and spreads passively across the cell membrane, decreasing in strength with time and distance
Excitatory Postsynaptic Potential (EPSP)
A depolarizing potential in the postsynaptic neuron that is caused by excitatory connections.
EPSPs increase the probability that the postsynaptic neuron will fire an action potential
Synaptic Delay
The brief delay between the arrival of an action potential at the axon terminal and the creation of a postsynaptic potential
Inhibitory Postsynaptic Potential (IPSP)
A hyper-polarizing potential in the postsynaptic neuron that is caused by inhibitory connections.
IPSPs decrease the probability that the postsynaptic neuron will fire an action potential
Chloride Ion (Cl-)
A chlorine atom that carries a negative charge because it has gained one electron
Spatial Summation
The summation at the axon hillock of postsynaptic potentials from across the cell body. If this summation reaches threshold, an action potential is triggered
Temporal Summation
The summation of postsynaptic potential that reach the axon hillock at different times. The closer in time the potentials occur, the more complete the summation
Exocytosis
The process by which a synaptic vesicle fuses with the presynaptic terminal membrane to release neurotransmitter into the synaptic cleft
v-SNARE
Specialized protein anchored to vesicles to aid their fusing to the presynaptic membrane to release neurotransmitter
t-SNARE
Specialized protein anchored to the presynaptic “target” membrane to bind v-SNAREs to dock vesicles, making them ready for release
Synaptotagmin
A specialized protein that responds to calcium ions to trigger vesicular exocytosis
Botulinum Toxin
A toxin that cleaves SNAREs, disabling neurotransmitter release
Tetanus Toxin
A toxin that cleaves SNAREs, disabling neurotransmitter release
Ligand
A substance that binds to receptor molecules, such as those at the surface of the cell
Acetylcholine (ACh)
A neurotransmitter produced and released by parasympathetic post-ganglionic neurons, by motor neurons, and by neurons throughout the brain
Receptor Molecule
A protein that binds and reacts to molecules of a neurotransmitter or hormone.
Also called a receptor
Endogenous Ligand
Any substances that is produced within the body and selectively binds to the type of receptor that is under study
Exogenous Ligand
Any substance that originates outside the body and selectively binds to the type of receptor that is under study
Curare
An alkaloid neurotoxin that causes paralysis by blocking acetylcholine receptors in the muscle
Bungarotoxin
A neurotoxin from the venom of the banded krait that selectively blocks acetylcholine receptors
Agonist
A molecule, usually a drug, that binds a receptor molecule and initiates a response like that of another molecule, usually a neurotransmitter
Antagonist
A molecule, usually a drug, that interferes with or prevents the action of a transmitter
Up-Regulation
A compensatory increase in receptor availability at the synapses of a neuron
Down-Regulation
A compensatory reduction in receptor availability at the synapses of a neuron
Ionotropic Receptor
A receptor protein that includes an ion channel that is opened when the receptor is bound by an agonist
Ligand-Gated Ion Channel
An ion channel that opens or closes in response to the presence of a particular chemical
Also called a chemically gated ion channel
Metabotropic Receptor
A receptor protein that does not contain an ion channel but may, when activated, use a G protein system to alter the functioning of the postsynaptic cell
G Proteins
A class of proteins that reside next to the intracellular portion of a receptor and that are activated when the receptor binds an appropriate ligand on the extracellular surface
Second Messenger
A slow-acting substance in the postsynaptic cell that amplifies the effects of synaptic activity and signals synaptic activity within the postsynaptic cell
Degradation
The chemical break-down of a neurotransmitter into inactive metabolites
Reuptake
The process by which released synaptic transmitter molecules are taken up and reused by the presynaptic neuron, thus stopping presynaptic activity
Transporter
Specialized receptor in the presynaptic membrane that recognizes transmitter molecules and returns them to the presynaptic neuron for reuse
Autoreceptor
A receptor for a synaptic transmitter that is located in the presynaptic membrane, telling the axon terminal how much transmitter has been released
Axo-Dendritic
Referring to a synapse in which a presynaptic axon terminal synapses onto a dendrite of the postsynaptic neuron
Axo-Somatic
Referring to a synapse in which a presynaptic axon terminal synapses onto the cell body (soma) of the postsynaptic neuron
Axo-Axonic
Referring to a synapse in which a presynaptic axon terminal synapses onto another axon’s terminal
Retrograde Synapse
A synapse in which a signal (usually a gas neurotransmitter) flows from the postsynaptic neuron to the presynaptic neuron, thus counter to the usual direction of synaptic communication
Dendro-Dendritic
Referring to a synapse in which a synaptic connection forms between the dendrites of two neurons
Ectopic Transmission
Cell-cell communication based on the release of neurotransmitter in regions outside traditional synapses
Varicosity
The axonal swelling from which neurotransmitter diffuses in a nondirected synapse
Non-Directed Synapse
A type of synapse in which the presynaptic and postsynaptic cells are not in close apposition; instead, neurotransmitter is released by axonal varicosities and diffuses away to affect wide regions of tissue
Neural Chain
A simple kind of neural circuit in which neurons are attached linearly, end to end
Knee-Jerk Reflex
A variant of the stretch reflex in which stretching a tendon below the knee leads to an upward kick of the leg
Convergence
The phenomenon of neural connections in which many cells send signals to a single cell
Divergence
The phenomenon of neural connections in which one cell sends signals to many other cells
Electroencephalogram (EEG)
A recording of gross electrical activity of the brain recorded from electrodes placed on the scalp
Epilepsy
A brain disorder marker by major sudden changes in the electrophysiological state of the brain referred to as seizures
Seizure
An epileptic episode
Tonic-Clonic Seizure
Also called grand mal seizure
A type of generalized epileptic seizure in which nerve cells fire high-frequency bursts
Simple Partial Seizure
Also called absence attack
A seizure that is characterized by a spike-and-wave EEG and often involves a loss of awareness and inability to recall events surrounding the seizure
Complex Partial Seizure
In epilepsy, a type of seizure that is characterized by a spike-and-wave EEG and often involves a loss of awareness and inability to recall events surrounding the seizure
Aura
In epilepsy, the unusual sensations or premonition that may precede the beginning of a seizure
Kindling
A method of experimentally inducing an epileptic seizure by repeatedly stimulating the brain region
Event-Related Potential (ERP)
EVOKED POTENTIAL
Averaged EEG recordings measures brain responses to repeated presentations of a stimulus
Optogenetics
The use of genetic tools to induce neurons to become sensitive to light, such that experimenters can excite or inhibit a cell by exposing it to light
Channelrhodopsin
A protein that, in response to light of the proper wavelength, opens a channel to admit sodium ions which results in excitation of the neuron
Halorhodopsin
A protein that, in response to light of the proper wavelength, opens a channel to admit chloride ions, which results in inhibition of neurons
