Neuropharm: NTs Flashcards
Cholinergic transmission is important for which fxns?
Cognitive fxn
Sensitization to incoming stimuli
Movement control
Hijacked by nicotine in tobacco addiction
What types of receptors are the two ACh receptors?
nicotinic AchR - ligand gated ion channels
muscarinic AchR - CGPCR
Where are cholinergic neurons found?
Concentrated in basal forebrain and pons
Numerous also found in cortex and basal ganglia
What are two examples of brain processes that dopamine transmission is important for?
Natural rewards and motor fxn
What diseases are problems in dopamine transmission implicated in?
Schizophrenia Parkinson's disease Addiction Depression ADHD
What kind of receptors are dopamine receptors?
GPCRs of two types
D1 type (including D1 and D5) D2 type (including D2, D3, D4)
Where are dopamine neurons found?
Midbrain, either in the VTA or substantia nigra pars compacta
NE activates ….
adrenergic receptors (GPCRs), mainly alpha 1 and/or alpha 2 in the CNS
NE is involved in …
memory
pain transmission
salience
NE transmission is altered in …
depression and addiction
NE neurons are located in …
pons, specifically locus coeruleus
Serotonin acts on what receptors/types
5-HT3 - ligand gated ion channels
5-HT1,2 - GPCRs (MOST)
What brain processes is serotonin important for?
reward
learning
mood/affect
What pathological states is serotonin thought to play a major role in?
depression
schizophrenia
mood disorders/anxiety?
Where are serotonin neurons located?
midbrain/pons, specifically raphae
