Neuropathic Pain

Question 1

Gabapentin

Answer 1

-FDA approved for PHN

Question 2

Pregabalin

Answer 2

-concomitant anxiety
-FDA approved in PDN, PHN, fibromyalgia
-disadvantages: Schedule V, dependency, euphoria

Question 3

Tramadol

Answer 3

-For moderate pain
-weak mu agonist
-less respiratory depression than others
-abuse potential
-DDI: CBZ, quinidine, TCA, SSRI
-SE: dizziness, GI, constipation, seizure risk

Question 4

Tapentadol (Nucynta)

Answer 4

-neuropathic pain associated with diabetic peripheral neuropathy
-weak anticholinergic effects
-schedule II

Question 5

Capsaicin

Answer 5

-FDA approved
-Use gloves when applying
-hot pepper (be careful with patient w/ dementia)

Question 6

Lidocaine

Answer 6

PHN, topical anesthesia
-5% patch, viscous soln 2%
- up to 4% patch (OTC)