Neurons Flashcards

1
Q

Impulse conduction

A
  • an AP causes an influx of Na+ across the membrane
  • reversal is the source of depolarizing current in adjacent membrane
  • AP propagates from origin across the rest of the cell
  • immediate
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2
Q

Vesicle release

A
  • AP current opens Ca++ channels
  • triggers cascade of reactions that result in exocytosis
  • change is slow because of the enzyme activity
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3
Q

Ionotropic effects

A
  • ligand binding opens an ion channel
  • causes a post-synaptic membrane potential (PSP)
  • 20-40 ms
  • cations = EPSP
  • Cl- or K+ = IPSP
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4
Q

Ionotropic Effect

A

Ligands are

  • Ach
  • glutamate
  • GABA
  • glycine
  • receptor determines effect, not the transmitter
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5
Q

Metabotropic

A
  • G-protein coupled receptor activated

- increase production or destruction of 2nd messenger

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6
Q

Spread of PSPs

A
  • generated in inexcitable membranes by binding of transmitter
  • graded potential (not AP)
  • passive conduction
  • magnitude lost over time
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7
Q

PSP summation

A
  • bad cable property
  • potential is lost across the membrane

two types:

  • spatial
  • temporal
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8
Q

spatial summation

A

10-30 EPSP generated at a different synapse

- graded potentials sum at trigger zone and generate an AP

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