Neurons Flashcards
Metabotropic receptors
Ligand binds to the receptor and activates intracellular events.
Insulin receptor-activates tyrosine kinase
Janus kinase-the receptor is different from the
GPCRs
Ionotropic receptor
Ligand gated ion channels that changes shape when a ligand binds.
Corticospinal neurons
Neurons that run the brain to the spinal chord. Cross over in the brain stem.
Increased diameter
Increased conductance.
Nernst equation
RT/ZF*ln(out/in)
Increased Nernst potential
Increased resting potential
Sodium potassium pump
Uses ATP to pump potassium in and sodium out. Creates the Na/K gradient which acts as a voltage source.
Voltage
(GnaEna+GkEk)/(Gna+Gk)
Curare
Antagonist to nicotine binding.
Excitatory
More likely to induce action potential
Inhibitory
Makes it less to have an action potential
Excitatory postsynaptic potential
Voltage increase in postsynaptic neuron.
Ech>T
A single EPSP will not always cause t to cross threshold instead they will have to sum
Synaptic Delay
The delay between the action potential in the presynaptic neuron and the EPSP in the postsynaptic neuron.
About 1ns
Inhibitory Postsynaptic Potential
Released neurotransmitter makes it harder for the postsynaptic neuron the fire.
Voltage gated Ca Channel
Tetramere
Sensitive to voltage and therefore opens with an AP.
Located in the presynaptic neuron and causes Ca to come in which causes the release of neurotransmitter from vesicles.