neuronal pigments/inclusions associated with disease Flashcards
intranuclear inclusions seen in herpes simplex encephalitis
Cowdry type A
cytoplasmic inclusions diagnostic of rabies
Negri bodies
neuronal inclusions characteristic of parkinson disease
Lewy bodies
cytoplasmic inclusion bodies associated with aging
Lipofuscin granules
dark cytoplasmic pigment in neurons of substantia nigra and locus coeruleus, not seen in patients with Parkinson
melanin
Parkinson- loss of melanin (dopamine is a precursor)
eosinophilic, rod-like inclusions in hippocampus of Alzeihmer patient
Hirano bodies
diagnostic of Alzheimer disease
Neurofibrillary plaques + tangles
filamentous inclusions that stain with silver, don’t survive neuronal death
Pick bodies
filamentous inclusions that stain with PAS and ubiquitin
Lewy bodies