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Low - MSK > Neuromuscular disorders > Flashcards

Neuromuscular disorders Flashcards

1
Q

Nocturnal leg cramp: treatment

A

Quinine

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2
Q

Quinine: MOA

A

RED excitability of motor endplate in response to acetylcholine

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3
Q

Quinine: indication

A

Malaria

Nocturnal leg cramps
- Regular sleep disturbance
- Failed non-pharmacological treatment
- Frequent or very painful
- Excluded treatable causes

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4
Q

Quinine: side effect

A

Toxic in OD (convulsion, arrhythmias)

Blindness, tinnitus
- CI: optic neuritis, tinnitus

QT prolongation
- Caution: conduction abnormalities, risk factors (hypoK)
- MHRA: reminder dose dependent

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5
Q

Spasticity: treatment

A

baclofen

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6
Q

Baclofen: MOA

A

Blocks NT at spinal level which relaxes skeletal muscles

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7
Q

Baclofen: indication

A
  • Chronic severe spasticity
  • Palliative care (painful spasms or hiccups)
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8
Q

Baclofen: route

A

Intrathecal: test dose, closely monitor + resuscitation

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9
Q

Baclofen : Side effect

A
  • Drowsiness
  • Muscular hypotonia
  • Avoid abrupt withdrawal
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Low - MSK (5 decks)

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