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Nurs 2514 final > Neuromuscular disorder > Flashcards

Neuromuscular disorder Flashcards

1
Q

Anatomy - Neurons

A

Nervous system - CNS (brain, spinal cord, cranial nerve 1-2), PNS (cranial nerve 3-12, spinal nerves, ANS)

Neurons = primary functional unit of nervous system that can excite, conduct and influence other neurons
Myelinated for rapid propagation and protection
Transmits nt across synapse
- GABA = inhibitory
- Glutamate/ACTH = excitatory
- Dopamine, NE, serotonin = both

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2
Q

Brain

A

1) Motor cortex - goal orientated movement/tasks
2) Basal ganglia - in cerebrum for movement
3) Cerebellum - motor control, coordination and balance

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3
Q

Spinal cord

A

Ascending pathway - sends sensory info to brain
Descending pathway - sends motor info to nerves

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4
Q

Spinal/peripheral nerves

A

i) Sensory/Afferent - ascending tract

ii) Motor/Efferent = descending tract
- Pyramidal neurons = voluntary movement
- Extrapyramidal neurons = involuntary movement (dysfunctional in parkinsons)
1) Upper motor neurons - between brain and spinal cord
2) Lower motor neurons - spinal cord to muscle

SAME DAVE
Sensory/afferent/dorsal
Motor/efferent/ventral

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5
Q

Multiple sclerosis

A

Autoimmune disorder that damages myelin sheath
- chronic inflammation and scarring of CNS that slows/blocks signals and impulses
- Periods of remission and exacerbations

Risk factors
- Female
- Vit d deficiency/cold climates
- Age onset of 30
- Genetic

Precipating factors
- Infection, poor health
- trauma, surgery
- Pregnancy
- Stress, fatigue

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6
Q

Clinical manifestations of MS

A
  • Tinnitus
  • Emotional lability - rapid exaggerated changes in mood
  • Apathy - impassiveness
  • Scanning speech/Spasmodic dysphonia
  • Diplopia
  • Nystagmus
  • Dysarthria = weak speaking muscles
  • Dysphagia
  • Atrophy
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7
Q

Parkinsons disease

A

Neurogenerative disease caused by lack of dopamine producing neurons that is required for extrapyramidal motor system

Risk factors
- Age of 60
- Male
- Antipsychotic meds
- Illicit drug use
- Dementia
- Exposure to chemicals

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8
Q

Clinical manifestations of Parkinsons

A

i) Tremors - pill rolling motion
ii) Rigidity
iii) Bradykinesia - lack of posture, deadpan, shuffling gait, drooling

Stages vary from initial, mild, moderate, severe and complete ADL dependency

Complications
- Aspiration/pneumonia
- UTI
- Pressure sores
- Malnourishment
- Falls

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9
Q

Spinal nerves (dermatomes/myotomes)

A

Motor+sensory
- Grey matter - voluntary and autonomic motor neurons
- White matter - sensory/motor (ascending/descending tracts)

Dermatomes = area of skin
Myotomes = muscle groups

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10
Q

Spinal cord injury (SCI)

A

Disruption in neuronal tissue within spinal canal as result of trauma, disease or degeneration (eg. disease, tumors, decreased blood supply, infection, etc.)

Classified by
i) Mechanism of injury
ii) Level of injury
iii) Completeness of degree of injury

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11
Q

Level of injury

A

1) Skeletal level of injury
2) Neurological level of injury

i) Tetraplegia = paralysis of arms, legs, trunk
- Damage of C8 and above
- C4 and above is total loss of respiratory muscle = ventilation required

ii) Paraplegia = paralysis of legs and trunk
- Damage between T1-T6
- Above T6 - Cardiovascular changes - bradycardia/hypotension

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12
Q

Clinical manifestations of SCI

A
  • DVT (from immobility)
  • Respiratory changes and cardiovascular changes
  • Urinary system, GI system like ulcer from steriods, paralytic ileus
  • Skin breakdown
  • Poikilothermia - temp regulation matches room tempP
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13
Q

Peripheral neuropathy

A

Neuropathic pain from destruction or inflammation

i) Mononeuropathy
-Postherpatic neuralgia - pain after blisters are healed eg. shingles
ii) Polyneuropathy
- Viral infection
- Botulism - neurotoxin exposure (Ragid)
- Tetanus - neurotoxin exposure (spasm)

Causes
- Diabetes : ischemia, inflammation
- Hypothyroidism
- Vitamin deficiency (Vit B12)
- Lyme disease
- Multiple sclerosis
- Mononeuropathy = impingement of nerve such as carpal tunnel

= clinical manifestation depends on what dermatome/myotome is effected

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14
Q

Clinical manifestations of SCI

A

Sensory and motor dysfunction
- Poorly localized
- Shooting, burning, fiery
- Shock-like tingling painful
- Numbness
- Sensitive to touch
- Weakness, paresthesia

Autonomic dysfunction
- Bowel, bladder, digestive dysfunction
- Heat intolerance
- HypotensionL

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15
Q

Levodopa/Carbidopa

A

Parkinsons

  • Levodopa = Coverted to dopamine (but does not cure disease, only delays progression), effectiveness decreases over time
  • Carbidopa = Decarboxylase inhibitor

AE
- N/V = direct stimulation of CTZ w dopamine
- Dyskinesia = can cause movement disorders, usually in long-term therapy (5-10 yrs)
- Postural hypotension
- Psychosis
-CNS effects - anxiety, agitation, memory loss, cognitive impairment,
- Darken sweat and urine

NC
- Avoid protein = competes with amino acids in absorption of the small intestines
- Assess extrapyramidal
- Monitor BP
- Fall risk - educate to stand up slowly

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16
Q

Acute loss of effect in Levodopa/Carbidopa

A

1) On/off phenomenon
- Abrupt return of PD symptoms
- Not dose dependent
Minimize by
- Dopamine agonist/MAO-b inhibitor
- Minimize protein

2) Wearing off phenomenon
- Gradual return = is dose-dependent
Minimize by
- Increase dose frequencies (shorter intervals)
- MAO-B inhibitor (prolong half life), dopamine agonist

17
Q

Pramipexole (Mirapex)

A

Dopamine receptor agonist

MOA - Stimulate dopamine receptors, usually first line drug as not broken down before BBB, does not compete with amino acid, lower dyskinesia
- Take several weeks to develop however

AE
- Dopamine receptors - naursea, dizzy, nausea, sleepy
- Othostatic hypotension, hallucination and dyskinesia risk increases when taken with levodopa
- Sleep attacks!!!!! = drug must be stopped immediately
- Impulse control disorders - hypersecuality, gambling, binge eating

NC
- PO
- Risk of drowsiness - avoid dangerous activities and CNS depressants
- Monitor BP regualrly

18
Q

Selegiline (Deprenyl)

A

MAO-B inhibitor
MOA - stops the enzyme MAO-B that breaks down dopamine
- Benefits with levodopa only works for 1-2 yrs

AE
- Insomnia
- Hypertensive crisis, esp in young people and high disease
- Worsen orthostatic hypotension, psychiatric and dyskinesia with levodopa

NC
- PO
- DO NOT take with meperidine or SSRI or opioids = serotonin syndome

19
Q

Anticholinergics

A

MOA - blocks ACTH, improves tremors but NOT bradykinesia

AE
- Blurred vision, dry mouth, constipation, urinary retention (SNS)

NC -
- Elder develop dementia (not prescribed if older than 70)

20
Q

Methylprednisolone (Solu-medrol)

A

Multiple sclerosis exacerbation

MOA - mimic cortisol for antiinflammation
- Prednisone in IV form

NC - monitor signs of acute infection as masks it, adrenal suppression, hyperglycemia, hypertension

21
Q

Interferon (Betaseron)

A

Immunomodulator (better)

MOA - glycoprotein that prevents leukocytes crossing BBB and suppress T-helper cell

AE
- Flu-like symptoms (HA, fever, chills, malaise etc) = decreases over time, give Tylenol
- Hepatoxic
- Myelosuppression
- Depression/suicidal ideation

CI - liver disease, alcoholism, depression

NC
- IM/Subcut
- Avoid hepaptoxic drugs, monitor CBC/LFT before, 1/3/6 months

22
Q

Mitoxantrone (Novantrone)

A

Immunosuppressant

MOA - CYTOTOXIC
- binds to DNA and kills rapidly dividing cells
plz don’t confuse with methotrexate they arent the sameeeeee

AE
- Myelosuppression
- Hepatoxic
- Cardiotoxic!!!
- Hair loss, N/V, mouth sores (pretty similar to cancer drugs)

NC
- Clinic - dose every 3 months for 2-3 yrs only cause so toxic
- Monitor GI - Antiemetic prophylactically
- Fluid/electrolytes, intake, output, all that fancy stuff
- EKG, chest cray, echo for EF before, during therapy
- IV administration - PPE required
- Immediately stop is pain, swelling, redness = extraversion

23
Q

Baclofen (Lioresal)

A

MS and SCI - Skeletal muscle relaxant

MOA - Replicate inhibitory GABA to suppress hyperactive reflexes

AE
- CNS depressant (improves over time)
- DO NOT STOP ABRUPTLY - Withdrawal symptoms like hallucination, seizures, paranoid ideation, taper over 1-2 weeks
- N/V
- Constipation, urinary retention
- Orthostatic hypotension

NC
- Oral or inthecal (into spinal fluid but higher risk of severe symptoms like fever, muscle rigidity, rebound spactiy, MOF, death)
- Caution with other CNS depressenat = Respiratory depression

24
Q

Gabapentin

A

Antiseizure med for neuropathic pain

MOA - Analog of gaba

AE - Well tolerated
- fatigue, ataxia, nystagmus, edema, dizzy = wears off usually
- Suicidal ideation
- Slow taper as risk of seizure if abruptly stopped

NC - Monitor for signs of CNS depresson, suicide etc

25
Q

Initial assessment

A

Neurologic assessment - Subjective
Past medical history, medication, surgery, nutrition, bowel/bladder, movement, sleep, cognition, sensation, mood, relationships etc.
History of presenting illness (HPI)

HA, head injury, dizziness/vertigo, seizures, tremors, weakness, coordination, numbess, difficulty swallowing, difficulty speaking, occupation risks

26
Q

1) Mental status

A

I) appearance - cleanliness, age, dress
ii) behaviour - level of eye contact, withdrawn, inappropriate behaviours
iii) LOC
iv) Mood/affect

27
Q

2) Cranial nerves :(

A

1) Olfactory
- Sensory of smell
- Vanilla extract, coffee beans

2) Optic
- Sensory of vision
- Visual field, optic disc, visual acuity

3) Oculomotor
- Motor
- Ptosis and PERRLA specific

4) Trochlear
- Motor (3,4,6)
- Extraocular movement, 6 cardinal psotions, convergence and accommodation
- Nystagmus is bad

5) Trigeminal
- Both
- Motor = palpate muscle tone of jaw, open jaw
- Sensory - touch face, cheek, chin etc

6) Abducens
- Motor (3,4,6)

7) Facial
- Both
- Symmetry with smiling, frown, close eyes tight, puff cheeks
- Tase

8) Vestibulocochlear
- Sensory of hearing
- Conversation, whisper voice test

9) Glossopharyngeal
- Both (9/10)
- Taste
- Swallow, gag reflex, mouth open wide for soft palate and uvula

10) Vagus
- Both (9/10)
- Heart/digestive too with reflexes such as sneezing, vomiting

11) Accessory spinal
- Motor
- Neck muscle, shrug against resistance

12) Hypoglossal
- Motor
- Stick out tongue
- Light, tight, dynamite

OOOTTAFVGVAH
Some say money matters but my brother says big brains matters most

28
Q

2) Spinal nerves - motor/sensory

A

Safety pin, q tip, coton wisp, warm/cold temperature

Motor system
- Pain, inspect, ROM, paresis, paralysis, passive/active ROM
- Spacticity/Rigidity
- Flexion/extension
- Pronator drift = hangs up, if one drifts down then muscle weakness or cerebral disease
- Grips - hand grip/push pedal

Sensory - light, pain sensation, temperature, position sense (move toe and ask where you moved it)

29
Q

5) Cerebral function

A

i) Romberg test - stand close eyes, do they sway?
ii) Rapid alternating finger = ask to touch finger to thumb
iii) Heel to toe test
iv) Rapid alternating hands = alternate hands on knees

30
Q

Multiple sclerosis health asssessment

A

Spasmodic dysphonia, ataxic gait

31
Q

Parkinsons health assessment

A

Pill rolling tremor, bradykinesia, jackknife/cogwheel rigidity, facial masking, hypokinetic parkinonian gait

32
Q

Complication of neuromuscular disease

A

i) Respiratory = aspiration, pneumonia, resp faliure

ii) Nutrition = malnutrition, dehydration asses dryness, turgor, intake, bp, bloodwork for creatinine BUN

iii) Skin = pressure sores, infection, contracture = temperature, CWSM, BP, braden scale, WBC for infection, cap refill

iv) Elimination = urinary retention, constipation - bladder scanner, bloow work, abdomen distention

v) Safety - falls, neurologic assessment, safety check

Nurs 2514 final (12 decks)

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