Neuromuscular Diseases And Disorders

Question 1

Treatment of neuromuscular disorders

Answer 1

Corticosteroids

Question 2

5 upregulation of receptors:

Answer 2

1. Motor neuron lesions (MS)
2. Muscle trauma
3. Burn injury
4. Immobilization
5. Sepsis/infection

Question 3

Upregulation of receptors resistance and enhancement response?

Answer 3

Resistant: nondepolarizing agent
Enhancement: depolarizing agent

Question 4

3 downregulation of receptors:

Answer 4

1. MG
2. Organophosphate poisoning
3. Chronic ACE-I exposure

Question 5

Downregulation of receptors resistance and enhancements response:

Answer 5

Resistant: depolarizing agent
Enhancement: non depolarizing agent

Question 6

Upregulation of nicotine receptors with the use of sux has the risk of what and that is why it is contraindicated?

Answer 6

Hyperkalemia

Question 7

What 4 drugs are metabolized by plasma cholinesterases?

Answer 7

Sux
Mivacurium
Remifentanil
Esmolol

Question 8

What is the most common muscular dystrophy and most severe form of childhood MD?

Answer 8

Pseudohypertrophic MD (duchenne MD)

Question 9

Avoid what 2 things in pseudohypertrophic MD?

Answer 9

Sux (risk of rhabdomyolysis, hyperkalemia, cardiac arrest)
Volatile anesthetics (risk of rhabdomyolysis, cardiac arrest)

Question 10

What does pseudohypertrophic MD look like?

Answer 10

MH

Question 11

Most common MD and most serious affecting adults that is inherited?

Answer 11

Myotonic dystrophy type 1

Question 12

What drug is contraindicated for myotonic dystrophy type 1?

Answer 12

Sux that causes prolonged skeletal muscle contraction

Question 13

Sudden onset of skeletal muscle weakness or paralysis usually triggered by an infectious process and typically starts at legs and spreads upward?

Answer 13

Guillain-Barré syndrome (acute idiopathic polyneuritis)