Neuromuscular Blockers - Quiz 7 Flashcards
How does Acetylcholine bind to the Nicotinic Receptor?
The positively charged Nitrogen binds to both alpha subunits of the nicotinic receptor, allowing Sodium to enter.
Which enzyme is responsible for the synthesis of Acetylcholine?
Choline Acetyltransferase
Choline + Acetyl CoA –> Acetylcholine
Which Autonomic System does Acetylcholine Activate?
Both
Primarily Rest & Digest, but also Kick starts the Sympathethic Nervous System
What deactivates Acetylcholine?
Acetylcholinesterase break down ACh into choline & acetate
Why are Neuromuscular Blockades used?
Cause paralysis to reduce complications d/t movement & help with intubation
What percentage of Suppression of Single Twitch Response is adequate for Surgery?
90%
What is the difference b/t Depolarizing & Non-Depolarizing Agents?
Depolarizing: constantly stimulates muscle fiber and cant respond to ACh
Non-Depolarizing: Competetively blocks ACh from receptor
What is ED95
NMB dose with non volatile anesthetic needed for 95% supression of single twitch during
ED95 is much less when used w/ gas
How much NMB is needed for Tracheal Intubation in terms of ED95?
2x ED95
What is the Order of Effect of NMBs?
Small quick moving muscles first (Eyes, Fingers)
then
Abdomen (Diaphragm) last
Reverses in reverse order d/t blood flow
What is the effect of NMBs at the Laryngeal Muscles vs Peripheral Muscles?
More Rapid & Less Intense @ Laryngeal Muscles
What are indicators of Laryngeal Relaxation when using NMBs?
Orbicularis Oculi - good indicator
Adductor Pollicis - poor indicator
What do the Non-Depolarizing NMBs break down into?
Benzylisoquinolinium - Histamine Release
Aminosteroid
What does the Quarternary Ammonium part of the NMB do?
Makes NMB highly ionized & water soluble - stays in blood
Does not cross into CNS or Placenta
Cant Give Orally
Binds to Alpha Subunits
What does it mean for NMBs to be non selective?
They will effects at both Autonomic Nicotinic & Cardiac Muscarinic receptors
Which Non-Depolarizing NMBs are Benzylisoquinoliniums?
NMBs that end with -curium
Which Non-Depolarizing NMBs are Aminosteroids?
NMBs that end with -curonium
Which Non-Depolarizing NMBs are Long Acting?
Pancuronium
Pipercuronium
Doxacurium
Which Non-Depolarizing NMBs are Intermediate Acting?
Vecuronium
Rocuronium
Atracurium
Cisatracurium
Which Non-Depolarizing NMBs are Short Acting?
Mivacurium
What is the only Depolarizing NMB used?
Succinylcholine
Intense Rapid Paralysis
Onset: 30-60 seconds
Duration: 3-5 minutes
What is the Mechansim of Action of Succinylcholine?
Binds to one or both alpha subunits @ Nicotinic receptor
Mimics ACh
What is the Mechansim of Action of Succinylcholine?
- Binds to one or both alpha subunits @ Nicotinic receptor
- Mimics ACh, but longer duration d/t slower hyrdrolysis
- Hyperpolarizes Receptor & no more ACh can activate the receptor
- Big Na+ influx causes Efflux of K+
What happens in Phase I of Block w/ Succinylcholine?
- Depolarizing receptor stimulation
- ↓Contraction to single twich
- ↓Ampltidude of continuous stimulation
- TOF > 0.7
- Muscle twitches @ onset