Neuromuscular Blockers Flashcards
Of the following ions (Ca 2+, K+, Cl-, Na+), which one does NOT pass through the nicotinic receptor at the neuromuscular junction?
Chloride
(Anions cannot pass through the nicotinic receptor- they’re repelled by the strong negative charge inside of the channel)
What enzymes metabolize succinylcholine and mivacurium?
- Plasma cholinesterase
- Pseudocholinesterase
- Butrylcholinesterase
- Type 2 cholinesterase
- False cholinesterase
What enzymes metabolize acetylcholine?
- Acetylcholinesterase
- Type 1 cholinesterase
- Specific cholinesterase
- Genuine cholinesterase
- True cholinesterase
What anti-emetic can prolong the DOA of succinylcholine?
Metoclopramide
What is Dibucaine and its relationship to plasma cholinesterase?
An amide local anesthetic that inhibits normal plasma cholinesterase. It has no effect on ATYPICAL plasma cholinesterase
What does a Dibucaine # of 80 signify?
Homozygous typical plasma cholinesterase
What does a Dibucaine # of 50 signify?
Heterozygous atypical plasma cholinesterase
What does a Dibucaine # of 20 signify?
Homozygous atypical plasma cholinesterase
What is the DOA of succs with homozygous typical plasma cholinesterase?
5-10 minutes
What is the DOA of succs with heterozygous atypical plasma cholinesterase?
20-30 minutes
What is the DOA of succs with homozygous atypical plasma cholinesterase?
4-8 hours
