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NUNA 680 - Pharm > Neuromuscular Blockade > Flashcards

Neuromuscular Blockade Flashcards

1
Q

What is the brand name for doxacurium?

A

Nuromax

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2
Q

What is the ED95 for doxacurium (Nuromax)?

A

0.03 mg/kg

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3
Q

What is the intubating dose for doxacurium (Nuromax)?

A

0.05-0.08 mg/kg

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4
Q

What is the onset for doxacurium (Nuromax)?

A

4-5 minutes

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5
Q

What is the duration of doxacurium (Nuromax)?

A

60-90 minutes (dose dependent = dd)

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6
Q

What is an advantage of doxacurium (Nuromax)?

A

No CV effects

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7
Q

Metabolism of doxacurium (Nuromax)?

A

Renal > hepatic

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8
Q

What is the brand name for pipecuronium?

A

Arduan

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9
Q

What is the ED95 for pipecuronium (Arduan)?

A

0.05 mg/kg

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10
Q

What is the intubating dose of pipecuronium (Arduan)?

A

0.085 mg/kg

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11
Q

What is the onset of pipecuronium (Arduan)?

A

3-5 minutes

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12
Q

What is the duration of pipecuronium (Arduan)?

A

60-90 minutes (dd)

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13
Q

Pipecuronium (Arduan) metabolism?

A

Renal > hepatic

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14
Q

What are the advantages of pipecuronium (Arduan)?

A

NO CV effects, NO histamine

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15
Q

What is the brand name for pancuronium?

A

Pavulon

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16
Q

What is the ED95 for pancuronium (Pavulon)?

A

0.07 mg/kg

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17
Q

What is the intubating dose for pancuronium (Pavulon)?

A

0.1 mg/kg

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18
Q

What is the onset of pancuronium (Pavulon)?

A

3-5 minutes

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19
Q

What is the duration of pancuronium (Pavulon)?

A

60-90 minutes

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20
Q

Metabolism of pancuronium (Pavulon)?

A

Renal > hepatic

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21
Q

What to remember about pancuronium (Pavulon)?

A

Vagolytic side effects

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22
Q

What is the brand name for vecuronium?

A

Norcuron

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23
Q

What is the ED95 for vecuronium (Norcuron)?

A

0.05 mg/kg

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24
Q

What is the intubating dose for vecuronium (Norcuron)?

A

0.1 mg/kg

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25
Q

What is the onset for vecuronium (Norcuron)?

A

2.3 minutes

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26
Q

What is the duration for vecuronium (Norcuron)?

A

45-60 minutes (dd)

27
Q

Metabolism of vecuronium (Norcuron)?

A

Hepatic > renal (both in first 24 hours)

28
Q

What should you remember about vecuronium (Norcuron)?

A

NOT vagolytic, NO histamine release, but CAN inhibit catabolism of histamine; a powder that must be reconstituted

29
Q

What is the brand name of mivacurium?

A

Mivacron

30
Q

What is the ED95 of mivacurium (Mivacron)?

A

0.08 mg/kg

31
Q

What is the intubating dose of mivacurium (Mivacron)?

A

0.15-0.2 mg/kg

32
Q

What is the onset of mivacurium (Mivacron)?

A

1.5-3 minutes

33
Q

What is the duration of mivacurium (Mivacron)?

A

10-20 minutes (dd)

34
Q

Metabolism of mivacurium (Mivacron)?

A

Plasma cholinesterase

35
Q

What should you remember about mivacurium (Mivacron)?

A

Prolonged action with atypical pseudocholinesterase or deficiency; anticholinesterases may prolong; causes HISTAMINE RELEASE

36
Q

What is the brand name of cisatracurium?

A

Nimbex

37
Q

What is the ED95 of cisatracurium (Nimbex)?

A

0.05 mg/kg

38
Q

What is the intubating dose of cisatracurium (Nimbex)?

A

0.2 mg/kg

39
Q

What is the onset of cisatracurium (Nimbex)?

A

2-3 minutes

40
Q

What is the duration of cisatracurium (Nimbex)?

A

20-35 minutes

41
Q

Cisatracurium (Nimbex) metabolism?

A

Hofmann elimination (organ independent)

42
Q

What should you remember about cisatracurium (Nimbex)?

A

Less of metabolite laudanosine produced than in atracurium since there is only one metabolism pathway (1/5?), NO histamine release

43
Q

What is the brand name for atracurium?

A

Tracrium

44
Q

What is the ED95 for atracurium (Tracrium)?

A

0.2 mg/kg

45
Q

What is the intubating dose for atracurium (Tracrium)?

A

0.5 mg/kg

46
Q

What is the onset for atracurium (Tracrium)?

A

2-3 minutes

47
Q

What is the duration of atracurium (Tracrium)?

A

20-35 min (dd)

48
Q

Metabolism of atracurium (Tracrium)?

A

Hofmann elimination, nonspecific plasma esterase (organ independent)

49
Q

What should you remember about atracurium (Tracrium)?

A

Causes HISTAMINE RELEASE; laudanosine is a metabolite which has to be eliminated by kidneys; drug must be refrigerated

50
Q

What is the brand name of rocuronium?

A

Zemuron

51
Q

What is the ED95 of rocuronium (Zemuron)?

A

0.3 mg/kg

52
Q

What is the intubating dose of rocuronium (Zemuron)?

A

0.6 mg/kg (dd)

53
Q

What is the onset of rocuronium (Zemuron)?

A

1-2 minutes

54
Q

What is the duration of rocuronium (Zemuron)?

A

20-35 minutes

55
Q

Metabolism of rocuronium (Zemuron)?

A

Hepatic > renal

56
Q

What should you remember about rocuronium (Zemuron)?

A

Used for rapid sequence induction (RSI), priming dose does not improve onset

57
Q

What is the brand name for succinylcholine?

A

Anectine

58
Q

What is the ED95 for succinylcholine (Anectine)?

A

0.3 mg/kg

59
Q

What is the intubating dose for succinylcholine (Anectine)?

A

1-1.5 mg/kg IV
OR
4-5 mg/kg IM

60
Q

What is the onset of succinylcholine (Anectine)?

A

45-90 seconds

61
Q

What is the duration of succinylchoine (Anectine)?

A

5-10 minutes

62
Q

What is the infusion concentration for succinycholine?

A

1 gm/500 mL and titrate to effect

63
Q

Metabolism of succinylcholine (Anectine)?

A

Plasma cholinesterase

64
Q

What should you remember about succinylcholine (Anectine)?

A

Used for RSI, difficult airway; MH trigger; causes hyperkalemia; usually phase I block (can be pushed into phase II); atypical plasma cholinesterase prolongs duration (hetero 30 min - dibucaine 40-60; homo >3 hours - dibucaine 20); causes myalgia (can be prevented with defasciculating dose of nondepolarizing NMB)

NUNA 680 - Pharm (8 decks)

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