Neurology Flashcards
Causes of ptosis with normal pupils
senile ptosis myotonic dystrophy fascioscapulohumeral dystrophy ocular myopathy thyrotoxic myopathy myasthenia gravis congenital
Causes of Horners
Pancoast tumour (tumour in apex of lung) Neck malignancy eg - thyroid brachial plexus lesion carotid artery lesion eg - aneurysm brainstem lesion eg - lateral meduallary syndrome
Features of third nerve palsy
Ptosis
Eye is down and out (divergent strabismus)
Mydriasis, unreactive to light or accommodation
Causes of CN3 palsy - by location
Problem at the nucleus - infarct, haemorrhage, mass
Problem at the fascicles - infarct, tumour, fasicles, demyelination
Problem in the subarachnoid space - Aneurysm (PCOmm)
Problem at the cavernous sinus - tumour, inflammation, carotid aneurysm
Causes of CN3 palsy - central or peripheral
Central causes - brain stem infarct, tumour, demyelination, trauma
Peripheral causes - Compression by eg aneurysm, tumour, raised intracranial pressure. Infarct from microvascular ischaemia (eg from diabetes, GCA), trauma, cavernous sinus lesion
Features of CN6 palsy
At rest - if severe affected eye adducted
Looking towards the lesion - affected eye unable to abduct, horizontal nystagmus
Looking away from lesion - normal
Causes of CN6 palsy
Vascular cause - infarct, haemorrhage, basilar artery aneurysm
Space occupying lesion in the pons
Demyelination - MS
Inflammatory - sarcoid, giant cell arteritis
Cavernous sinus lesion
Mononeuritis multiplex
Trauma
Central - vascular, tumour, Wernicke’s encephalopathy, MS
Peripheral - microsvascular ischaemia (eg - diabetes), trauma, raised intracranial pressure
Causes of jerky horizontal nystagmus
Vestibular (peripheral) - unidirectional with fast component is away from the side of the lesion
Vestibular (central) - bidirectional, left beating on left gaze, right beating on right gaze
Cerebellar - fast component towards the side of the lesion
Toxins - phenytoin, alcohol
Causes of jerky vertical nystagmus
Brain stem lesion
- Upbeating: lesion at floor of 4th ventricle
- Downbeating: lesion at foramen magnum
Toxins - phenytoin, alcohol
Causes of mononeuritis multiplex
Rheumatologic conditions - Sjogrens, SLE, RA
Vasculitis - PAN, giant cell arteritis
Other chronic conditions - diabetes, neurosarcoid, amyloidosis
Paraneoplastic
Infections such as HIV
Causes of peripheral neuropathy
D - drugs and toxins like isoniazid, vincristine, platinum based chemo
A - Alcohol, amyloid
M - Metabolic like diabetes, thyroid, uraemia
I - Immune mediated like GBS
T - tumour, lung carcinoma, paraproteinaemia
B - vitamin B12 deficiency
I - Idiopathic
C - Connective tissue disease or vasculitis
H - Hereditary motor and sensory neuropathy
Signs of median nerve lesion
- Weak thumb abduction
- Wasting of the thenar eminence
- Hand of benediction if more proximal lesion
- Sensory loss to the palmar aspect of thumb, index and middle (and half of ring)
Signs of a radial nerve lesion
- Wrist drop/finger drop
- Sensory loss over the anatomical snuffbox
- Weak elbow extension if high enough
- Absent triceps jerk
Signs of ulnar nerve lesion
- Wasting of the hypothenar eminence
- Weak abduction and adduction
- Claw hand when trying to straighten
- Sensory loss over the dorsal and palmar little and half of ring finger
How do you distinguish a C8 nerve root lesion/lower trunk brachial plexus lesion from ulnar nerve lesion?
- sensory loss of a C8 root/lower trunk plexus extends above the wrist
- Thenar wasting with C8 root/lower trunk plexus
Signs of femoral nerve lesion
- Weak knee extension
- Loss of sensation over inner thigh and leg
- Strong adduction
- Slight weak hip flexion
Signs of sciatic nerve lesion
- Foot drop
- Knee Extension weakness
- loss of sensation in posterior part of thigh and all of lower leg
- Loss of power to all muscles below knee
- Unable to stand on toes or heels
- Loss of ankle jerk
Common peroneal nerve lesion
- Foot drop
- Loss of sensation to the dorsum of foot
- Weak eversion
- Normal power inversion (L5 nerve root will be all of above and weak inversion)
Nerve fibre types for motor and sensory
Motor - Large myelinated nerve fibres
Proprioception and vibration - large myelinated nerve fibres (A-beta)
Pain and temperature - small myelinated and unmyelinated fibres
Autonomic - small fibres
Nerve fibre types for motor and sensory
Motor - Large myelinated nerve fibres
Proprioception and vibration - large myelinated nerve fibres (A-beta)
Pain and temperature - small myelinated and unmyelinated fibres
Which nerve pathways carry pain/temperature vs vibration/proprioception
DCML - fine touch, proprioception and vibration
Lateral spinothalamic tract - pain and temperature
Causes of mononeuritis multiplex
Metabolic causes - Diabetes Vasculitis - PAN, Churg-Strauss, Wegeners Connective tissue - RA, SLE, Sjogrens Sarcoid Amyloid Paraneoplastic
Tests to order for peripheral neuropathy
Bloods - FBC, ESR, CRP, U and E, TFTs, HbA1c, B12, Serum protein electrophoresis, Autoimmune profile Urine - Bence jones, glucose Nerve conduction Genetic testing Nerve biopsy
Peripheral neuropathies that are predominantly motor
CIDP GBS CMT Porphyria Lead poisoning
Axonal vs demyelinating polyneuropathy
Axonal - more distal sensory loss, wasting and weakness of hands/feet
Demyelinating - vibration/proprioception (large myelinated fibres) loss > pain/temp, weakness can be more generalised
Demyelinating vs axonal neuropathy features on NCS
Demyelinating - slow nerve conduction velocities, prolongation of distal latencies
Axonal - reduced amplitude of evoked compound action potentials, relative preservation of the nerve conduction velocity
If there is wasting of the hand in a neuro exam, when can the pathology originate from?
Anterior horn cell, nerve root or the lower motor neurons that arise from C8 to T1
Clinical features of Charcot Marie Tooth disease
- Pes cavus - high arch, short foot, hammer toe
- Inverted champagne bottle legs
- Distal muscle atrophy and weakness - mainly hands and feet. Get weak eversion
- Absent reflexes
- Foot drop
- Thickened nerves - esp lateral popliteal nerve
- Sensory loss - vibration and proprioception
- Claw hand
- Optic atrophy
Nerve conduction studies in CMT disease
Can be motor and sensory involved
Can be predom axon or demyelinating or mixed
Demyelinating - get decreased conduction velocities
Axonal - get decreased amplitudes
Differentiating neuropathy from myopathy
Myopathy - usually more proximal, no fasciculations, no sensory loss, deep tendon reflexes intact unless severe, can have mm tenderness
Neuropathy - usually more distal, fasciculations, can have sensory loss, loss of reflexes
What are the main clinical features of myotonic dystrophy?
Face - frontal balding, facial muscle atrophy (temporalis, masseter, sternomastoid), high arched palate (some), ptosis, cataracts
Neck - weak neck flexion
Hands - grip myotonia, percussion myotonia
Wasting UL and LL esp intrinsic hand mm
What are some of the systemic features of myotonic dystrophy?
Cardiac - arrythmias, heart block, mitral valve prolapse, cardiomyopathy
GIT - dysphagia, hypomotility, reflux, delayed gastric emptying
Endocrine - diabetes, hypogonadism, nodular thyroid involvement