Neurology

Question 1

What is glutamate made from? What enzyme converts it?

Answer 1

Glycine

Phosphate activated glutaminase

Question 2

Name 3 ionotropic receptors of Glutamate. Where are they?

Answer 2

POST

AMPA, NMDA, KAINATE

Question 3

Name 3 metabotropic receptors of Glutamate. Where are they?

Answer 3

Group 1 - mGlu1, mGlu5 = POST
Group 2 - mGlu2, mGlu3 = PRE
Group 3 - mGlu4,6,7,8 = PRE

Question 4

How is GABA formed? What breaks it down?

Answer 4

Glutamate —+GAD, vit b6—-> GABA

GABA transaminase

Question 5

How is Glycine formed?

Answer 5

Ser —Ser Hydroxymethyltransferase –> Glycine

Thre ———Thre Aldolase——————-> Glycine

Question 6

Name two ionotropic receptors for inhibitory amino acid NTs

Answer 6

• GABAa

- Glycine

Question 7

The metabotropic receptor GABAb is a channel to which ion?

Answer 7

K+

Question 8

How is seratonin made?

Answer 8

• L-Tryptophan –+T hydroxylase –> 5-hydroxyLtryptophan

- —+L aromatic acid decanboxylase –> 5HT

Question 9

What is the only ionotropic 5HT receptor?

Answer 9

5HT3

Question 10

What is the amino acid precursor of dopamine?

Answer 10

Tyrosine ( –> DOPA –> Dopamine)

Question 11

All DA receptors are metabotropic, where are which ones?

Answer 11

• D1 and D5 are PRE

- D2, D3 and D4 are BOTH

Question 12

Name the one Acetylcholine ionotropic receptor and its one metabotropic receptor. (BOTH pre&post)

Answer 12

• Ionotropic is nicAch R

- Metabotropic is Musc Ach R