Neurology Flashcards
Which modality leaves the spinal cord at the following region:
Dorsal root ganglion
Anterior horn
- Dorsal root ganglion - Sensory cell bodies
- Anterior horn – Motor cell bodies
What is an upper motor neurone (UMN)?
All CNS structures
- Brain
- Spinal cord
What are the UMN signs?
- Hypertonia - Rigidity + Spasticity
- Clonus
- Brisk reflexes
- Weakness
- Babinski reflex - Up going plantars
What is a Lower motor neurone (LMN)?
All PNS structures
- Nerve root (Anterior horn cell)
- Peripheral nerves
- Neuromuscular junction
What are the LMN signs?
- Weakness + Wasting in motor unit
- Reduced tone (Flaccid)
- Fasciculation
- Reduced/Absent reflexes
What do the following control?
Corticospinal tract
Spinothalamic tract
Dorsal columns (Fasciculus cuneatus & Gracilis)
- Corticospinal tract – Movement
- Spinothalamic tract - Pain & Temperature
- Dorsal columns (Fasciculus cuneatus & Gracilis) – Vibration & Proprioception
Where do the corticospinal tracts decussate?
Medulla
What is Brown Sequard syndrome?
Hemisection of the spinal cord (Other side remains in tact)
- UMN signs
- Loss of sensation ipsilateral and at level of lesion
- Loss of vibration & proprioception ipsilateral to lesion
- Loss of temperature & Pinprick contralateral to the lesion
Where do the dorsal columns decussate?
Where does the spinothalamic tract decussate?
- Dorsal columns – Medulla
- Spinothalamic tract – Spinal cord, at level of entry of neuron
What is Dysarthria?
What is Dysphasia?
Dysarthria – Slurred speech due to motor deficit (Broca’s area)
Dysphasia – Disturbance of language leading to either speech problems or understanding (Wernickes)
- Expressive - Difficulty finding words
- Receptive - Difficulty understanding words spoken
What are the causes of dysarthria?
- Lesions of tongue/lips/mouth
- Bulbar palsy - Bilateral LMN lesion
- Cerebellar dysfunction
- Myasthenia gravis
- Parkinsonism
Damage to which part of the brain would lead you to expect dysphasia/dysarthria?
- Left side
- Most common in R + L handed people, in L handed people it may be the R side.
What are the following, where are they found?
Broca’s area
Wernicke’s area
Broca’s area – Inferior frontal region
- Word production & language expression
Wernicke’s area – Superior posterior temporal lobe
- Comprehension & Spoken language
What are the functions of the frontal lobe?
- Personality
- Emotional response
- Social behaviour
- Smell
- Posterior part contains the pre-central gyrus (Motor strip) – Controls voluntary movement
What are the functions of the parietal lobe?
- Calculation
- Language
- Planned movement
- Spatial awareness
- Anterior part contains the post-central gyrus – Sensory strip (Conscious sensation)
What are the functions of the occipital lobe?
- Vision
- Vision interpretation
What are the functions of the temporal lobe?
- Auditory perception
- Speech and language
- Non-verbal memory
You are asked to do a cranial nerve examination on a patient, what are the steps?
[Introduction]
- Wash hands & Introduce self
- Ask Patient name & DOB & Age
- Today I am going to be doing a neurological examination, to identify if there is anything going on with your brain or your nerves.
- Is that what you were expecting?
- For the examination I will need access to your upper limbs and lower limbs, so it is best if you undress to your underwear and put a robe on.
- The examiner will act as a chaperone for both of us
- To start the examination for the cranial nerves which supply your face I will need you sat facing me on a chair
- Do you have any pain at the moment?
[General Inspection]
- Assess the surrounding area
- Walking aids
- Assess the patient - SWIFT
- Do they look well at rest?
- Body habitus
- Scars
- Wasting
- Involuntary movements
- Fasciculations
- Tremor
[CN 1 - Olfactory nerve]
- Sense of smell (CN1)
- Not useful clinically unless pt reports loss of sense of smell in Hx
[CN 2, 3, 4, 6 - Optic/Occulomotor/Trochlear/Abducens]
AFRO - Acuity/Fields/Reflexes/Opthalmoscope
Visual acuity:
- If patient reports changes to their vision in Hx
- Measure visual acuity with a Snellen chart
Visual fields:
- Can you please cover your left eye with your left hand, and I will cover my right eye
- Can you keep looking at my face, and tell me when you notice my fingers/this red pin coming into your view
- Move the red pin inside slowly from all 4 corners of the visual field towards the centre of vision
- Ensure red pin is equal distant between myself and the patient
- Compare my visual field with the patient to determine if abnormal
- Repeat for R eye - You cover your R eye with your R hand, and I will cover my L eye
Pupillary reflexes:
- I’m just going to have a look at your pupils in your eyes briefly, so if you could keep them open and stare over my shoulder at something on the wall
- Inspect both pupils closely for discrepancy in size or shape
- Ok now I will be shining a bright light into your eye, it should be painful but let me know if it is too much
- Bring in the light from the side - avoids accommodation reflex
- Check both eyes with the light
- 1. Direct reflex - Shine torch in patients eye SAME pupil should constrict
- 2. Consensual reflex - Shine torch into pts eye and the OTHER pupil should constrict
-
3. Swinging light test - Move torch from eye to eye, back and forth If relevant Afferent Pupillary Defect (RAPD) -> Paradoxical pupil dilation
- Defect in the direct response - When the light reaches a pupil there should be a normal direct and consensual response, when the light is shone in the AFFECTED pupil it remains dilated after light being shone in the healthy pupil
Eye movements:
- Now I am going to be checking your eye movements
- What I would like you to do, is to follow my finger with your eyes, but keep your head still
- Hold finger approx 50cm away b/w me and patient
- Let me know if you get pain or double vision whilst looking at my finger
- Move finger in H pattern, assess for:
- Nystagmus
- Opthalmoplegia
- If patient notes double vision, identify if it is:
- Maximum/Vertical/Horizontal/Tilted
- Does closing one eye make the double vision better?
Saccades:
- Hold palm to one side of patient and fist to the other side of the patient
- Can you keep your head still and look at my fist then look at my palm and alternative between them
- Rapid eye movements - b/w the two -> Saccades
Fundoscopy:
- Darken the room
- Take the fundoscope and tell patient: I’m going to be having a look into the back of your eye.
- I’ll have to get very close to your face and will put my hand on your shoulder to steady myself.
- Is that ok?
- Examine the eye:
- Look for red reflex from afar then move in closer
- Disc
- Cup
- Colour
- Contour
- Papilloedema (Sign of Raised ICP)
- Pale disc (Sign of previous optic neuropathy)
[CN 5 - Trigeminal nerve]
- Assess if a patient reports numbness in the face - check sensation in the face
- Ophthalmic branch - V1
- Maxillary branch - V2
- Mandibular branch - V3
- Test muscles of mastication - Inspect for muscle wasting
- Temporalis
- Masseter
- Medial & Lateral Pterygoids
- Jaw power
- Place hand under jaw as resistance, ask patient to open jaw -> Note deviation
- Corneal reflex test - Offer. lightly touching a wisp of cotton wool to the patients cornea, causing them to blink
- Assess Ophthalmic branch -> Sensation, Facial nerve -> Blink the eye itself
- Jaw jerk reflex
[CN 7 - Facial nerve]
- Now Im going to be having a look at the nerve that supplies your face
- Observe for signs of
- Weakness
- I’m going to ask you to do a range of facial expressions to me, so if you could just copy me that would be great
- Can you raise your eyebrows
- Does the forehead wrinkle on both sides?
- Can you close your eyes really tight?
- Assess for asymmetry
- Keep your eyes closed and I want you to stop me from opening them - resistance
- Note signs of weakness
- Can you keep your lips tightly shut for me, and don’t let me open them
- Note signs of weakness
- Can you show me your teeth?
- Note any asymmetry
- Can you puff out your cheeks?
- Stop me from pushing them in
- Can you raise your eyebrows
- Anterior 2/3 taste on tongue
- Have you noticed any change to your taste in the front of your tongue?
- Offer to test taste
- Any change to your hearing?
[CN 8 - Vestibulococchlear]
- If patient reports problems with hearing or balance (CN8)
- Check hearing
- Briefly rustling your finger and thumb in front of each ear to see if they can perceive
- Rinne - Not usually performed in neurology
- Webers test - Not usually performed in neurology
[CN 9 & 10 - Glossopharyngeal + Vagus nerve]
- Pharynx
- Next i’m going to look inside your mouth - Ill just get a tongue depressor
- Get tongue depressor & pen torch
- Inspect the palate and the uvula Does the uvula deviate to one side?
- Can you please say aaahhhh
- Palate and uvula should move UP
- Testing:
- CN 9 -> Sensation
- CN 10 -> Motor function
- Extra tests
- If the patient reported problems with swallowing:
- Ask patient to swallow and observe this -> CN 9 & 10 (Rarely tested)
- Ask patient to cough
- If the patient reported problems with swallowing:
- If you suspect problems with the patients speech - formally assess speech
- Ask them to repeat “yellow lorry” or “Baby hippopotamus”
- Can you blow out your cheeks and keep the air in there
- Listen for air escaping through nose, as for cheeks to puff out the palate must elevate to block the nasopharynx -> Air escaping shows weak palate
- Offer Gag reflex
[CN 11 - Accessory nerve]
- If you suspect weakness in shoulders and neck
- Ask pt to shrug shoulders - then do it against resistance
- Ask patient to turn their head against resistance
[CN 12 - Hypoglossal Nerve]
- Next i’m just going to have a look at your tongue
- Assess the tongue for:
- Fasciculations
- Muscle wasting
- Can you please stick your tongue out, assess for:
- Deviation
- Can you wiggle your tongue side to side
- Check for speed of tongue movement
You are asked to do a Upper limb neurological examination on a patient, what are the steps?
[Introduction]
- Wash hands & Introduce self
- Ask Patient name & DOB & Age
- Today I am going to be doing a neurological examination, to identify if there is anything going on with your brain or your nerves. Is that what you were expecting?
- For the examination I will need access to your upper limbs and lower limbs, so it is best if you undress to your underwear and put a robe on. The examiner will act as a chaperone for both of us
- Do you have any pain at the moment?
[General Inspection]
- Assess the surrounding area
- Walking aids
- Assess the patient - SWIFT
- Do they look well at rest?
- Body habitus
- Scars
- Wasting
- Involuntary movements
- Fasciculations
- Tremor
- Posture
Limb exam
The next stage of the exam is to have a look at your limbs, and how they are functioning
- Are you right or left handed?
- I will need you to sit on the bed for this part of the exam
- Upper limbs - sitting
- Lower limbs - lie down
[Inspection]
Assess for muscle wasting in the
- Upper limb
- Fasciculation – Assess for irregular ripples or twitches which are associated with muscle wasting
Look at:
- Tap over muscles as this may elicit them
- Tremor Assess the UL/LL for any signs of a tremor
- Describe the tremor - Is it fast/slow or Fine/course
- Examine UL at rest -> on posture -> and during coordination testing
- Myoclonic jerks Assess for sudden shock like contractions
- Are the focal/diffuse/singular/repetitive
- Deformity & Posture
- Typical UMN problems can cause adduction of the shoulder, flexed elbow, flexed wrist
- Pronator drift
- Can you stick your arms straight out please with your palms UP
- Can you close your eyes
- Assess for
- Normal - Arms remain stationary
- Arms drifting down and pronation
- Suggest lesion in the pyramidal tracts -> UMN lesion
- Ask patient to stick arms straight out please with palms DOWN
- Checking pseudoathetosis & Tremor
[Tone]
- Hold pts hand as if shaking it and support at the elbow with the other hand
- Can you please relax your arm completely - keep talking to the patient
- Rotate forearm - Pronation/Supination
- Flexion/Extension of the wrist
- Flexion/Extension of the elbow
- Rigidity -> Stiffness that remains throughout the entire movement, regardless of speed of movement.
- NON velocity dependent (Lead pipe/Cog wheel)
- Evidence of extrapyramidal lesion -> Parkinson’s disease
- Spasticity -> Stiffness that is exacerbated when there is an attempt to move the limb quickly.
- IS velocity dependent (Clasp knife)
- Evidence of pyramidal lesion
[Power]
- Assess UL power Shoulder abduction - Don’t let me push your shoulders down
- C5
- Elbow flexion - Dont let me pull your elbows away from your body
- C5/6
- Elbow extension - Don’t let me push your elbows into your body
- C7
- Wrist flexion - Dont let me pull your wrist away from your body
- C7
- Wrist extension - Dont let me push your wrist away from your body
- C6
- Finger extension - Dont let me push your fingers away from your body
- C7
- Finger flexion - Dont let me pull your fingers away from your body
- C8
- Finger abduction - Dont let me push your fingers back together
- T1
- Thumb abduction - Dont let me push your thumb back towards your index finger
- T1
MRC Muscle strength reporting:
- Grade 0 -> No power
- Grade 1 -> Twitching but no movement
- Grade 2 -> Movement, but cannot overcome gravity
- Grade 3 -> Can overcome gravity
- Grade 4 -> Movement against gravity and resistance
- Grade 5 -> Normal muscle strength
[Reflexes]
- Now I’m going to check your reflexes, can you please relax for me
- Assess for muscle contraction - not limb movement Try 2 times - then try reinforcement
- UL -> Clench your teeth
- Grade the reflex
- Reduced/absent -> LMN lesion
- Normal
- Increased/brisk -> UMN lesion
- Biceps jerk C5
- Fingers on biceps tendon
- Supinator jerk C5/6
- Fingers on tendon (Brachioradialis)
- Triceps jerk C7
- Hold patients arm out with elbow flexed and hand facing down
- Strike tendon directly
[Coordination]
- Finger-nose test
- Hold finger at arms length in front of the patients nose
- Ask patient to repeatedly touch b/w their nose and the tip of my finger
- Cerebellar lesions -> finger to under or over shoot (Past pointing)
- Cerebellar lesions -> Intention tremor - fine tremor just before touching your finger
- Ask patient to close eyes Repeat the test to touch b/w nose and tip of finger in same position
- If unable to tell position of finger w/o vision -> Sensory ataxia
- Dysdocokinesia
- Can you put your hands palm up on your other palm, then alternate
- Repeat this
- Look for:
- Fatigue
- Lack of coordination
[Sensation]
- Use neurotip - pin (Superficial pain)
- I’m going to test the sensation if your UL now with this neurotip/cotton wool
- I’m just going to show you what it feels like now on your forehead.
- I will then ask you to close your eyes, and tell me when you get the same sensation again somewhere on your body
- Test in dermatomal pattern
- Compare one arm to the other
- C4 -> Above shoulder tip
- C5 -> Regimental badge area
- C6 -> tip of thumb
- C7 -> Tip of middle finger
- C8 -> Tip of little finger
- T1 -> Medial forearm
- T2 -> Medial upper arm
- T3 -> Axilla
- if there is a deficit - try to map out the region affected
- Sensory inattention
- Ask patient to close their eyes
- Touch their arms/legs in turn - which side has been touched?
- Touch both sides at the same time - ask whether the left/right/both sides were touched?
[Proprioception]
- If Hx suggests impaired proprioception, hold IP joint of thumb and ask patient to close eyes
- Ask them to identify whether you are holding their toe UP or DOWN
[Vibration]
- Next I’m going to be testing your ability to sense vibrations in your UL
- Use 128Hz tuning fork
- I’m just going to show you what the vibrations are like on your forehead.
- I will then ask you to close your eyes and tell me when you get the same sensation again somewhere on your body
- I want you to tell me when you feel the buzz, not the cold metal
- Place tuning fork on bony prominences:
- Finger - can you feel this?
- Close your eyes now and tell me when the vibration stops
- If deficit -> try more proximal body prominences
[Complete examination]
- Thank patient & Wash hands
- “This is patient x who is a x year old Male/Female with the following findings”
- I would take a full Hx + examine any other relevant systems
- I would consider the differentials
- I would order relevant investigations
- Observations
- Bloods
- Imaging
- I would initiate management of the most likely differential
You are asked to do a lower limb neurological examination on a patient, what are the steps?
[Introduction]
- Wash hands & Introduce self
- Ask Patient name & DOB & Age
- Today I am going to be doing a neurological examination, to identify if there is anything going on with your brain or your nerves. Is that what you were expecting?
- For the examination I will need access to your upper limbs and lower limbs, so it is best if you undress to your underwear and put a robe on. The examiner will act as a chaperone for both of us
- Do you have any pain at the moment?
[General Inspection]
- Assess the surrounding area
- Walking aids
- Assess the patient - SWIFT
- Do they look well at rest?
- Body habitus
- Scars
- Wasting
- Involuntary movements
- Fasciculations
- Tremor
[Other tests]
Gait
- So now I would like to assess your walking – Can you walk from point A to B for me. Assess for:
- Stride length
- Symmetry
- Ease of turning
If normal -> What I would like you to do next is to walk heel-toe like your are walking on a tight rope please
- Emphasise any gait ataxia
Rombergs
- Can you stand straight in front of me, hands by your sides, feet together and close your eyes
- Ready to catch them if they become unsteady
- Normal -> Maintain position w/o losing balance
- Eyes open -> visual feedback aiding balance
- If swaying/lurching/unable to stand -> Cerebellar ataxia
- Eyes closed -> Reliance on proprioception for balance If impaired - pt cannot tell position in space w/o visual feedback, so will lose balance. -> Sensory ataxia (Dorsal column damage)
[Inspection]
- Wasting
- Assess for muscle wasting
- Fasciculation – Assess for irregular ripples or twitches which are associated with muscle wasting
- Look at:
- Tap over muscles as this may elicit them
Tremor Assess the LL for any signs of a tremor
- Describe the tremor - Is it fast/slow or Fine/course
- Examine UL at rest -> on posture -> and during coordination testing
Myoclonic jerks Assess for sudden shock like contractions
- Are the focal/diffuse/singular/repetitive
[Tone]
- Test LL tone
- Can you please relax your legs completely - keep talking to the patient
- Roll leg from side to side
- Look for normal movement of the foot
- Lift knee slowly
- Then lift knee quickly of bed
- Heel should stay on bed - If foot lifts off and catches -> increased tone, UMN lesion
- If this happens with rapid movements -> Spasticity (Velocity dependent increase in tone)
- Rigidity -> increased tone = through all speeds of passive movement
Clonus
- Rapidly dorsiflex the foot and hold
- Look for clonus -> Sign of spasticity
- >4 beats -> Pathological, UMN pathology
[Power]
- Hip flexion - Dont let me push your leg into the bed
- L1/2
- Knee extension - Dont let me push your shin into the bed
- L3/L4
- Ankle dorsiflexion - Don’t let me push your foot away from your body
- L4
- Great toe dorsiflexion - Don’t let me push your toe away from your body
- L5
- Ankle plantar flexion - Don’t let me push your foot towards the floor
- S1
- Knee flexion - Dont let me lift your shin off the bed
- L5/S1
- Hip extension - Dont let me lift your leg off the bed
- L5/S1
MRC Muscle strength reporting:
- Grade 0 -> No power
- Grade 1 -> Twitching but no movement
- Grade 2 -> Movement, but cannot overcome gravity
- Grade 3 -> Can overcome gravity
- Grade 4 -> Movement against gravity and resistance
- Grade 5 -> Normal muscle strength
[Reflexes]
- Now I’m going to check your reflexes, can you please relax for me
- Use the tendon hammer - strike tendon not the muscle
- Assess for muscle contraction - not limb movement Try 2 times - then try reinforcement
- LL -> Grasp your hands and pull
Grade the reflex
- Reduced/absent -> LMN lesion
- Normal
- Increased/brisk -> UMN lesion
LL reflexes
- Knee L3/4
- Knee relaxed and slightly flexed + external rotation
- Watch quadriceps muscle for contraction
- Ankle S1/2
- Hip abducted/externally rotated - flex knee
- Dorsiflex the ankle - to stretch tendon
- Strike the achilles tendon -> Warch for calf muscle contraction/ankle plantar flexion
- Plantar reflex
- Run orange stick up the lateral border of the foot from the heel to the little toe, then run it medially towards the big toe
- Look for INITIAL reaction of the big toe
- Big toe DOWN -> Normal reflex
- Big toe UP -> abnormal Babinksi reflex (Upgoing) -> UMN lesion
[Coordination]
- Heel-shin test
- Ask patient to bring heel to shin and lift off at knee and repeat
- Perform this with R & L leg
[Sensation]
- I’m going to test the sensation if your UL/LL now with this neurotip (Superficial pain)
- I’m just going to show you what it feels like now on your chest. I will then ask you to close your eyes, and tell me when you get the same sensation again somewhere on your body
- Compare one arm/leg to the other
- L2 -> Antero-medial mid thigh
- L3 -> Medial thigh just above the knee
- L4 -> Medial malleolus
- L5 - Dorsal 1st web space
- S1 -> Lateral little toe + Lateral heel
- if there is a deficit - try to map out the region affected
- Sensory inattention
- Ask patient to close their eyes
- Touch their arms/legs in turn - which side has been touched?
- Touch both sides at the same time - ask whether the left/right/both sides were touched?
[Proprioception]
- If Hx suggests impaired proprioception, hold IP joint of big toe/thumb and ask patient to close eyes
- Ask them to identify whether you are holding their toe UP or DOWN
[Vibration]
- Next I’m going to be testing your ability to sense vibrations in your UL/LL
- Use 128Hz tuning fork
- I’m just going to show you what the vibrations are like on your chest. I will then ask you to close your eyes and tell me when you get the same sensation again somewhere on your body
- I want you to tell me when you feel the buzz, not the cold metal
- Place tuning fork on bony prominences:
- Great toe - bony prominence
- Close your eyes now and tell me when the vibration stops
- If deficit -> try more proximal body prominences
- Impaired vibration sense -> Dorsal column pathology (Vibration/Proprioception)
[Complete examination]
- Thank patient & Wash hands
- “This is patient x who is a x year old Male/Female with the following findings”
- I would take a full Hx + examine any other relevant systems
- I would consider the differentials
- I would order relevant investigations
- Observations
- Bloods
- Imaging
- I would initiate management of the most likely differential
You are asked to assess the cerebellar function, as part of a neurological examination. What are the steps?
[Introduction]
- Wash hands & Introduce self
- Ask Patient name & DOB & Age
- Today I am going to be doing a neurological examination, to identify if there is anything going on with your brain or your nerves. Is that what you were expecting?
- For the examination I will need access to your upper limbs and lower limbs, so it is best if you undress to your underwear and put a robe on. The examiner will act as a chaperone for both of us
- To start the examination for the cranial nerves which supply your face I will need you sat facing me on a chair, but for the rest of the examination its best if you are sat on a couch.
- Do you have any pain at the moment?
[Focused questions]
- What happened when you first presented with his condition?
- How is it affecting you?
- When is your tremor worse?
[General Inspection]
- Assess the surrounding area
- Walking aids
- Assess the patient - SWIFT
- Do they look well at rest?
- Body habitus
- Scars
- Wasting
- Involuntary movements
- Fasciculations
- Tremor
[Gait]
- Can you walk from A - B, I will be nearby in case you feel unsteady
- Can you walk heel to toe if you can?
- Assessing for ataxic gait
- Can you sit in a chair with your arms folded
- Assessing for truncal ataxia
[Posture]
- Can you stand with your feet together for me?
- Can you close your eyes (Rombergs test)
- Assess stability, for sensory ataxia
- Can you close your eyes (Rombergs test)
[Face]
- H test for extraoccular muscle function
- pause at lateral gaze
- Assessing for:
- Nystagmus
- Saccades
- Can you look from one target to another
- Hypometric saccades
[Speech]
- Say “Baby hippopotamus” and “British constitution”
- Assessing for slurring/Staccato speech
[Upper limbs]
- Wasting – Assess for muscle wasting in the
- Upper limb
- Fasciculation – Assess for irregular ripples or twitches which are associated with muscle wasting
- Tap over muscles as this may elicit them
Tremor Assess the UL/LL for any signs of a tremor
- Describe the tremor - Is it fast/slow or Fine/course
- Examine UL at rest -> on posture -> and during coordination testing
Myoclonic jerks Assess for sudden shock like contractions
- Are the focal/diffuse/singular/repetitive
Deformity & Posture
- Typical UMN problems can cause adduction of the shoulder, flexed elbow, flexed wrist
Pronator drift
- Can you stick your arms straight out please with your palms UP
- Can you close your eyes
Assess for
- Normal - Arms remain stationary
- Arms drifting down and pronation
- Suggest lesion in the pyramidal tracts -> UMN lesion
Ask patient to stick arms straight out please with palms DOWN
- Checking pseudoathetosis & Tremor
[Tone]
Test UL tone
- Hold pts hand as if shaking it and support at the elbow with the other hand
- Can you please relax your arm completely - keep talking to the patient
- Rotate forearm - Pronation/Supination
- Flexion/Extension of the wrist
- Flexion/Extension of the elbow
- Rigidity -> Stiffness that remains throughout the entire movement, regardless of speed of movement.
- NON velocity dependent (Lead pipe/Cog wheel)
- Evidence of extrapyramidal lesion -> Parkinson’s disease
- Spasticity -> Stiffness that is exacerbated when there is an attempt to move the limb quickly.
- IS velocity dependent (Clasp knife)
- Evidence of pyramidal lesion
[Coordination]
- Finger-nose test
- Hold finger at arms length in front of the patients nose
- Ask patient to repeatedly touch b/w their nose and the tip of my finger
- Cerebellar lesions -> finger to under or over shoot (Past pointing)
- Cerebellar lesions -> Intention tremor - fine tremor just before touching your finger
- Ask patient to close eyes Repeat the test to touch b/w nose and tip of finger in same position
- If unable to tell position of finger w/o vision -> Sensory ataxia
[Lower limbs - Tone]
- Can you please relax your legs completely - keep talking to the patient
- Roll leg from side to side
- Look for normal movement of the foot
- Lift knee slowly
- Then lift knee quickly of bed
- Heel should stay on bed - If foot lifts off and catches -> increased tone, UMN lesion
- If this happens with rapid movements -> Spasticity (Velocity dependent increase in tone)
- Rigidity -> increased tone = through all speeds of passive movement
Clonus
- Rapidly dorsiflex the foot and hold
- Look for clonus -> Sign of spasticity
- >4 beats -> Pathological, UMN pathology
[Coordination]
- Heel-shin test
- Ask patient to bring heel to shin and lift off at knee and repeat
- Perform this with R & L leg
[Complete examination]
- Thank patient & Wash hands
- “This is patient x who is a x year old Male/Female with the following findings”
- I would take a full Hx + examine any other relevant systems
- CN exam with fundoscopy
- Full neurological exam
- I would consider the differentials
- I would order relevant investigations
- Observations
- Bloods
- Imaging
- I would initiate management of the most likely differential
What are the signs of cerebellar dysfunction?
DANISH
- D - Dysdiadokinesia + Dysmetria (Past pointing)
- A - Ataxia
- N - Nystagmus
- I - Intention tremor
- S - Slurred/Staccato speech
- H - Hypotonia
What are the causes of Cerebellar disease?
MAVIS
- M - MS
- A - Alcohol
- V - Vascular
- I - Inherited
- S - SoL
You are asked to interpret a CT brain scan, what are the steps to do this?
- Isodense – Same as brain
- Hyperdense – Brighter than brain
- Hypodense – Darker than brain
[Identification]
- Name
- Date of birth/Age
[Scan details]
- Date
- Time
- Orientation
- Contrast
- Windowing
[Describe lesion]
- Site – Where is the lesion?
- Shape – Diffuse or well-circumscribed? Smooth or irregular?
- Homogeneity – Homogenous or inhomogeneous?
- Enhancement – Enhancing or non-enhancing?
- Associated features – oedema, dural origin, calcification?
[Specific features]
- Midline – Midline shift
- Ventricles – Blood & mass effect
- Cisterns – Blood and pus
- Parenchyma – Ischaemia & bleeding
- Sulci – Blood & prominence
- Sinuses – Blood and pus
- Bones – Fracture
- Soft tissues - Haematoma
What is MS?
- Cell mediated autoimmune condition - with repeated episodes of inflammation of the central nervous system
- Leads to loss of the myelin sheath - both grey + white matter
- Requires separate lesions in both time & space
What causes MS?
- Inflammation leads to – Multiple areas of scar tissue (Sclerosis) along neurons
- Slowing ± blocking transmission of signals to and from brain – Spinal cord
- Genetic & Environmental causes
- Linked to EBV – Molecular mimicry
What are the different patterns of MS?
Relapsing remitting – Most common
- Relapse of symptoms - new lesion formation.
- Followed by remission for some time (Re-myelination)
Primary progressive
- From beginning
- Symptoms gradually develop and worsen over time, no remissions.
Secondary progressive
- Follows on from relapsing remitting MS
- Gradually more/worse symptoms with fewer remissions
Who is most likely to develop MS?
- Caucasians
- Women
- 20-40yrs peak incidence
- FHx of MS
What are the classical symptoms of MS?
- UMN Signs
- Limb weakness
- Optic neuritis - Acute/painful reduction or loss of vision in one eye
- Diplopia
- Facial weakness
- Deafness
- Vestibular dysfunction
- Sensory deficits
- Autonomic system dysfunction - Bladder & Bowel symptoms
If you suspect a patient may have MS, what investigations should be done?
- Clinical diagnosis + MRI to confirm
- MRI brain & Spinal cord (Focal demyelination in brain or spinal cord)
- At >1 site + >1 month b/w attacks
- LP
- Increased protein
- Increased IgG concentration - Oligoclonal bands
- Delayed evoked potentials (Nerve stimulation studies)
If you have confirmed a diagnosis of MS, how is it managed?
- Patient education
- Inform DVLA
Relapse:
- IV Methylprednisolone (High dose steroids)
- Gastric protection - Ranitidine/Omeprazole
- Bone protection - Bisphosphonates
Disease modifying drugs:
- Monoclonal antibodies
- Dimethyl Fumarate
- Plasma exchange
A patient presents with the following Hx, what are the differentials to be considered?
A 28-year-old white woman who has smoked 1 pack per day for the last 10 years presents with subacute onset of cloudy vision in 1 eye, with pain on movement of that eye. She also notes difficulty with colour discrimination, particularly of reds. She was treated for a sinus infection 2 weeks ago and on further history recalls that she had a 3-week history of unilateral hemibody paraesthesias during examination week in university 6 years ago. She occasionally has some tingling on that side if she is overly tired, stressed, or hot.
MS******
Myelopathy due to cervical spondylosis
Stroke
GBS
B12/Folate deficiency
Peripheral neuropathy
A patient presents with the following Hx, what are the differentials to be considered?
A 31-year-old woman with strong family history of autoimmune disease is 6 months postnatal and develops ascending numbness and weakness in both feet, slightly asymmetrically, over a period of 2 weeks. She gradually develops difficulty walking to the point where she presents to an emergency department and is also found to have a urinary tract infection.
MS******
Myelopathy due to cervical spondylosis
Stroke
GBS
B12/Folate deficiency
Peripheral neuropathy
If a patient presents with weakness, what could be the cause of the problem:
CNS
PNS
CNS
- Motor cortex
- Brainstem
- Spinal cord (Myelopathy)
- Anterior horn cell
PNS:
- Nerve root (Radiculopathy)
- Nerve plexus (Plexopathy)
- Peripheral nerve (Peripheral neuropathy)
- Neuromuscular junction
- Muscle (Myopathy)
A patient presents with symptoms in the following time frame, what are the likely differentials?
Sudden onset
Acute onset (Minutes to hrs)
Subacute (Days to weeks)
Chronic (Months to years)
Sudden onset
- Traumatic
- Vascular (Infarction/ICH/SAH)
Acute onset (Minutes to hrs)
- Vascular (Central Venous Sinus Thrombosis)
- Infections (Meningitis/Encephalitis)
- Drug reactions
Subacute (Days to weeks)
- Infections (TB Meningitis)
- Cerebral abscess
- Autoimmune (MS)
Chronic (Months to years)
- Genetic (DMD/Neurodegenerative Parkinsons)
- Metabolic (Wilsons)
- Neoplastic (Glioblastoma)
Where do the CN’s leave the brain?
- CN 1 + 2 – Leave from the cerebrum
- CN 3 + 4 – Leave from the midbrain
- CN 5-8 – Leave from the Pons
- CN 9 - 12 – Leave from the Medulla (Bulbar)
What is meant by the terms:
Pyramidal
Extra-pyramidal
Pyramidal – Motor tracts that originate in the cerebral cortex, carrying motor fibres to the spinal cord and brain stem. They are responsible for the voluntary control of the musculature of the body and face.
- Corticospinal tracts – supplies the musculature of the body.
- Corticobulbar tracts – supplies the musculature of the head and neck
Extra-pyramidal – Motor tracts originate in the brain stem, carrying motor fibres to the spinal cord. They are responsible for the involuntary and automatic control of all musculature, such as muscle tone, balance, posture and locomotion
- The vestibulospinal and reticulospinal tracts do not decussate, providing ipsilateral innervation
- The rubrospinal and tectospinal tracts do decussate, and therefore provide contralateral innervation
You are asked to examine the UL dermatomes as part of a neurological exam, which nerve supplies which part of the upper limb?
- C4 – Shoulder tip
- C5 – Regimental badge
- C6 – Tip of thumb
- C7 – Tip of middle finger
- C8 – Tip of little finger
- T1 – Medial forearm
- T2 – Medial upper arm
- T3 – Axilla
You are asked to examine the UL myotomes as part of a neurological exam, which nerve supplies which part of the upper limb?
- C4 – Shoulder Adduction
- C5 – Shoulder abduction
- C5/6 – Elbow flexion
- C7 – Elbow extension
- C6 – Wrist extension
- C7 – Finger extension
- C8 – Finger flexion + Thumb extension
- T1 – Thumb abduction + Finger Abduction
You are asked to examine the UL reflexes, which nerves supply the reflex arc?
- Suppinator jerk:
- Brachioradialis muscle – C5/6
- Biceps – C5
- Triceps – C7
You are asked to examine the LL dermatomes as part of a neurological exam, which nerve supplies which part of the upper limb?
- L2 – Antero medial mid thigh
- L3 – Medial thigh just above knee
- L4 – Medial malleolus
- L5 – Dorsal 1st web space
- S1 – Lateral little toe + Lateral heel
You are asked to examine the LL myotomes as part of a neurological exam, which nerve supplies which part of the upper limb?
- L2 – Hip flexion
- L3+4 – Knee extension
- L4 – Ankle dorsiflexion
- L5 – Great toe dorsiflexion
- S1 – Ankle plantarflexion
- S1 – Knee flexion
- S4 – Bladder + Rectum motor supply
You are asked to examine the LL reflexes, which nerves supply the reflex arc?
- Knee reflex – L3/L4
- Ankle – S1/S2
What is the significance of the following signs on visual field testing?
Homonymous Hemaniopia
Bitemporal hemaniopia
Monocular blindness
- Homonymous Hemaniopia – Occipital cortex/Optic radiation lesion
- Bitemporal hemaniopia – Optic chiasm lesion
- Monocular blindness – Optic nerve
What is Guillain Barre syndrome?
- Acute inflammatory neuropathy
- Causes demyelination & Axonal degeneration (Peripheral neuropathy)
- Usually preceeded by infection
What are the characteristics of GBS?
Acute Ascending + Progressive neuropathy
- Weakness
- Hyporeflexia
- Parasthesiae
- Polyradiculoneuropathy
What usually causes GBS?
Usually Hx of preceeding infection (URTI or GI infection) within 6 weeks of neurological symptoms
Commonly caused by infection from:
- Campylobacter Jejuni
- EBV
- CMV
Who classically gets GBS?
- Males > Females
- 15-35yrs or 50-75yrs
- Past Hx of GI or Upper respiratory tract infection
- Recent vaccinations
- Malignancy – Lymphoma
- Pregnancy/Post partum
How does GBS classically present (Symptoms/Signs)?
- Hx of viral illness
- Weakness:
- Ascending pattern (Starts in LL)
- Progressive + Symmetrical
- Weakness stops progressing
- May have facial weakness
- Neuropathic pain
- LMN signs
- Bulbar dysfunction
- Autonomic symptoms
A patient presents with the following Hx, what is the most likely diagnosis? What are the differentials?
A 20-year-old woman with no significant past medical history presents with lower back pain and bilateral foot and hand tingling. Her symptoms rapidly progress over 4 days to include lower extremity weakness to the point that she is unable to mobilise her lower extremities. She reports coryzal symptoms 2 weeks ago. On examination, she has 0/5 power in her lower extremity with areflexia, but despite the paraesthesias she does not have sensory deficits. Her aminotransferases are elevated, and lumbar puncture reveals mildly elevated protein with no cells and normal glucose. She weighs 70 kg and her admission vital capacity is 1300 mL, maximum inspiratory pressure is -30 cmH₂O, and maximum expiratory pressure is 35 cmH₂O.
- Guillain Barre syndrome
- Stroke/Brainstem compression
- Cord compression
- Transverse myelitis
- Vasculitis
- Encephalitis
- Myasthenia gravis
A patient presents with the following Hx, suggestive of GBS. What investigations should be ordered?
A 20-year-old woman with no significant past medical history presents with lower back pain and bilateral foot and hand tingling. Her symptoms rapidly progress over 4 days to include lower extremity weakness to the point that she is unable to mobilise her lower extremities. She reports coryzal symptoms 2 weeks ago. On examination, she has 0/5 power in her lower extremity with areflexia, but despite the paraesthesias she does not have sensory deficits. Her aminotransferases are elevated, and lumbar puncture reveals mildly elevated protein with no cells and normal glucose.
Clinical diagnosis:
- Hx
- Neurological examination
- Progressive weakness in UL + LL
- LMN signs
Bloods
- FBC – Normal.
- U&E – Normal
LP:
- Increased protein
- Normal cell count
Nerve conduction studies:
- Abnormal – Slowing of nerve conduction velocities (Repeat after 2wks)
LFTs: Increased AST + ALT
How is a patient with confirmed GBS managed?
- Plasma exchange
- IV Ig
- DVT Prophylaxis:
- S/C Heparin/Enoxaparin + TED Stockings
- Intubation ± ventilation if respiratory distress
- Rehabilitation
- Pain relief for neuropathic pain
What are the complications of GBS?
- Persistent paralysis
- Hypotension/HTN
- Respiratory failure
- Aspiration pneumonia
What is transverse myelitis?
Focal inflammation of the spinal cord
Leads to:
- Motor weakness
- Sensory impairment
- Autonomic dysfunction
What can cause transverse myelitis?
- MS
- Infection – HSV/HZV/EBV/TB/Syphillis
- Post vaccination
- SLE/Sjogrens syndrome
- Saracoidosis
- Paraneoplastic syndrome
What are the different types of transverse myelitis?
Acute partial transverse myelitis
- Usually post infection due to acute spread of infection
- Affects 1-2 vertebral segments
- Asymmetric spinal cord lesions
- Increased risk of developing MS
Longitudinally extensive TM:
- Asymmetric or Symmetric spinal cord lesions
- Span >3 contiguous vertebrae
- Typically bilateral symptoms
- Increased risk of Neuromyelitis Optica
Who typically gets transverse myelitis?
- Peak age 10-20yrs and 30-40yrs
- Typically heralds or accompanies MS
- Female
People with:
- Recent infection/vaccination
What are the classical symptoms/signs of Transverse myelitis?
- Motor weakness:
- Progressive weakness affecting LL or All extremities
- Asymmetrical or Symmetrical
- Pyramidal pattern
- Parasthesia or sensory loss
- Urinary & bowel dysfunction
- Back pain
- UMN signs
A patient presents with the following symptoms, what is the most likely diagnosis? What are the differentials?
A 26-year-old woman with no significant medical history presents with a 5-day history of left lower extremity paraesthesias that subsequently ascended the left trunk to the level of the umbilicus. She also reports new-onset urinary frequency and that her right leg drags during ambulation. On examination, she has a partial Brown-Sequard’s syndrome with mild pyramidal weakness and impairment of vibration and proprioceptive sensation involving the right lower extremity, and reduced appreciation for pain throughout the left lower extremity and trunk below T11. The right plantar response is extensor.
- Transverse myelitis
- MS
- GBS
- Anterior/Posterior spinal artery occlusion
- Myasthenia gravis
- B12/Folate deficiency
A patient presents with the following symptoms, what is the most likely diagnosis? What are the differentials?
A 45-year-old woman with a history of Hashimoto’s thyroiditis presents with a 2-day history of progressive bilateral upper and lower extremity numbness, paraparesis, bladder incontinence, mid-thoracic back pain, and L’hermitte’s sign (limb paresthesias upon neck flexion). On examination, she has 4/5 power in the distal upper extremities, 1/5 power in her lower extremities with symmetric hyper-reflexia, clonus, and Babinski’s signs. There is a bilateral sensory level at T4 and loss of vibratory and proprioceptive sensation in the feet, and she is unable to walk.
- Transverse myelitis
- MS
- GBS
- Anterior/Posterior spinal artery occlusion
- Myasthenia gravis
- B12/Folate deficiency
A patient with the following symptoms suggestive of acute transverse myelitis presents. What investigations should be carried out?
A 45-year-old woman with a history of Hashimoto’s thyroiditis presents with a 2-day history of progressive bilateral upper and lower extremity numbness, paraparesis, bladder incontinence, mid-thoracic back pain, and L’hermitte’s sign (limb paresthesias upon neck flexion). On examination, she has 4/5 power in the distal upper extremities, 1/5 power in her lower extremities with symmetric hyper-reflexia, clonus, and Babinski’s signs. There is a bilateral sensory level at T4 and loss of vibratory and proprioceptive sensation in the feet, and she is unable to walk.
MRI Spinal cord:
- Exclude compressive SC lesion
- Intrinsic cord lesion - Diagnostic
MRI brain
- No lesions, Assess for MS or Neuromyelitis Optica
LP:
- Increased WCC
- Increased protein
- Abnormal Oligoclonal bands
- If normal – Recheck in 2 weeks to confirm
How is Transverse myelitis managed?
- Corticosteroids – Methylprednisolone for 3-5 days
- Neuropathic pain management
- Catheter if acute urinary retention
- DVT Prophylaxis
You are asked to interpret the lumbar puncture results of a patient presenting with a number of symptoms. What do the results suggest?
- Clear and colourless appearance.
- Protein level - 0.2-0.4 g/L (neonate <1.7 g/L).
- Glucose level - 60-80% of plasma glucose.
- WCC <5 per mm3
- Opening pressure 10-20 cm H2O
Normal
You are asked to interpret the lumbar puncture results of a patient presenting with a number of symptoms. What do the results suggest?
- Cloudy and turbid CSF (if severe).
- Raised protein >1.5 g/L.
- Glucose level is <50% of the plasma level.
- Cell count is high (>1,000 per mm3) and mostly neutrophils.
- Opening pressure is high.
Bacterial meningitis
You are asked to interpret the lumbar puncture results of a patient presenting with a number of symptoms. What do the results suggest?
- Clear CSF
- Protein is raised or normal
- Glucose level is usually within normal limits
- Cell count is high and mostly lymphocytes
- Opening pressure may or may not be raised
Viral Meningitis
You are asked to interpret the lumbar puncture results of a patient presenting with a number of symptoms. What do the results suggest?
- May be blood stained/Xanthochromia (Yellow)
- Protein is raised or at the high end of normal
- Glucose level is usually low
- High number of RBCs, Normal WCC count
- Opening pressure is usually high if excessive RBCs are present
Subarachnoid Haemorrhage
Which location is a LP done?
- L4/L5 disc space
- Line from ASIS - marks the L5 vertebrae level
What are the contraindications for a LP?
- Patient is too unstable
- Signs of Raised ICP:
- Change to GCS
- HTN
- Bradycardia
- Focal neurological signs
- Papilloedema
- Suspected SoL
- Bleeding disorder
- Local cellulitis at site of LP
What are the signs of raised ICP?
- Change to GCS
- HTN
- Bradycardia
- Focal neurological signs
- Headache
- Diplopia
- Papilloedema
- Kernigs sign – Patient supine, thigh flexed to 90deg, try to straighten leg – Resistance
- Brudzinki’s sign – Flexion of neck leads to involuntary flexion of knees + hips
What are the signs of Meningococcal meningitis/Sepsis?
- Non-blanching rash
- Unwell looking patient
- Purpura
- Capillary refill >2s
- Neck stiffness
Signs of raised ICP:
- Change to GCS
- HTN
- Bradycardia
- Focal neurological signs
- Papilloedema
What is Meningitis?
What causes viral/bacterial meningitis?
Inflammation of the meninges due to pathogen
Bacteria –
- Strep Pneumoniae (Pneumococcal)
- Nesseria meningitis (Meningococcal)
- Haemophilus Influenza (Hib)
Virus
- HSV1/2
- EBV
- Coxsackie virus
A patient presents with the following Hx, what is the most likely diagnosis? What are the differentials?
A 1-month-old girl presents to her general practitioner with a high fever, feeding difficulties, and irritability for the past 24 hours. Examination reveals altered mental status and a bulging fontanelle.
- Bacterial Meningitis
- Viral meningitis
- Encephalitis
- Drug induced meningitis
A patient presents with the following Hx, what is the most likely diagnosis? What are the differentials?
An 18-year-old male student presents with severe headache and fever that he has had for 3 days. Examination reveals fever, photophobia, and neck stiffness.
- Bacterial meningitis
- Viral meningitis
- Encephalitis
- Drug induced meningitis