neurology Flashcards

(123 cards)

1
Q

what is a febrile fit?

A

seizure in presence of fever

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2
Q

age of febrile fit

A

6 months to 6 years of age

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3
Q

causes of febrile fit

A

immature brain more susceptible to environmental changes/factors

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4
Q

what increases risk feb fit

A

fam history 1/4 will have one

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5
Q

can be secondary to

febf it

A

uti, urti, gastroenteritis
otitis media
etc

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6
Q

does feb fit increasee risk of epilepsy

A

nuh uh bruh

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7
Q

when does fever occur with feb fit

A

usually precedes convulsions

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8
Q

how long does convulsion tend to last

with feb fit

A

3-6 minutes

tend to occur once in 24 hr

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9
Q

how does convulsion present with feb fit

A
twitching of the face
arms legs
eye rolling
stifness
jerking 
loss of consciousness

generalised tonic clonic

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10
Q

what do you need to rule out when child comes in with query feb fit

A

any serious causes such as meningitis and encephalitis

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11
Q

What can increase seizure risk with febrile fits

A

if > 20 minutes

family hx

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12
Q

what type of seizure is febrile fit

A

temporal lobe

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13
Q

when do you need to do a hospital assessment

with feb fit

A

<18 months
first seizure or was not assessed after first seizure

serious cause
parental anxiety
There is diagnostic uncertainty about the cause of the seizure.
There were any of the following features:
The seizure lasted for more than 15 minutes, or
There were focal features during the seizure, or
recurred in the same febrile illness, or within 24 hours, or
incomplete recovery after one hour.

The child has no serious clinical findings but is currently taking antibiotics or has recently been taking them.

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14
Q

management of feb fit

A
ABCDE 
recovering position
infer over >5-10mins MIDAZOLAM
infection source find
if suspecting mengitis do LP
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15
Q

advice to parents of feb fit

A
reasurrance
protect head
do not restrain or put anything in mouth
remove nearby danger
very common
high temp causes it- no longstanding brain damage
not same as epilepsy and doesn't increase risk -very mariginaly different 
antipyrexical don't help 
1-3 another episode

acute management if happens again-undress. give paracetamol, fluid intake, fan
< 5 mins seek help

When the seizure stops, check their airway and place them in the recovery position.
If the seizure lasts more than 5 minutes give:
Rectal diazepam repeated once after 5 minutes if the seizure has not stopped, or
One dose of buccal midazolam.

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16
Q

doses of rectal diazepam

A

ecommended doses of rectal diazepam (repeated after 5 minutes if necessary) are:
Less than 1 month of age: 1.25–2.5 mg.
1 month–1 year of age: 5 mg.
2–11 years of age: 5–10 mg.

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17
Q

mizadolam doses

A

Midazolam may be given as a single dose by the buccal route (intravenous solution for injection should be administered into the buccal cavity between the gum and cheeks using a syringe or straw), although it is not licensed for this indication. Recommended doses of midazolam are:
Less than 6 months of age: 300 micrograms/kg body weight (maximum 2.5 mg).
6 months–11 months of age: 2.5 mg.
1–4 years of age: 5 mg.
5–9 years of age: 7.5 mg.

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18
Q

when to call ambulance with feb fit

A

all an emergency ambulance if, 10 minutes after the first dose:
The seizure has not stopped.
The child has ongoing twitching (although the larger jerking movements have stopped).
Another seizure has begun before the child regains consciousness.
Measure blood glucose if the child cannot be roused or is convulsing.

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19
Q

nice guidelines about parental advice with feb fit

A

Inform parents about the nature of febrile seizures:
Febrile seizures are not the same as epilepsy. The risk of epilepsy developing later is low but slightly higher than the general population.
Short-lasting seizures are not harmful to the child.
About 1 in 3 children will have another febrile seizure.
Advise parents on what to do if a further seizure occurs. They should:
Protect them from injury during the seizure.
Not restrain them or put anything in their mouth.
Check their airway and place them in the recovery position when the seizure stops. Explain that the child may be sleepy for up to an hour after the seizure.
Seek medical advice if a seizure lasts for less than 5 minutes, or call an ambulance if the seizure continues for more than 5 minutes.
Advise parents about managing fever, but explain that reducing fever does not prevent recurrence. Advice should cover:
When and how to use ibuprofen and paracetamol to reduce fever.
Practical measures on how to reduce fever and prevent dehydration.
When to seek medical help because of prolonged symptoms, or deterioration, especially if there are features of a serious underlying cause for the infection, such as meningitis.
For further information see the CKS topic on Feverish children - management.
Advise parents to continue childhood immunizations even if the febrile seizure followed an immunization.
Do not prescribe drugs to manage or prevent future seizures unless advised to do so by a specialist. This may be advised following assessment of a child with an indication for urgent admission.
Arrange follow-up, the timing of which will depend on the clinical condition of the child.

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20
Q

what is a breath holding attack

how long

A
infant usually or toddler is upset angry or scared they tend to be trigged by trauma or anger
can be caynatoic
appear to stop breathing on exhalation 
its involuntary 
lasts less than. 1min
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21
Q

episodes include

BHA

A

prolonged crying and bread held can lead to cynaosis
grow out by 5 years usually 6 to 18months
F=M

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22
Q

two types of BHA

A

cyanotic and pallid spells

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23
Q

describe each bHA

A
cyanotic
preceipated by crying 
 very upset
deep breath
cyanotic
limb extend 
may be stiff or floppy
cn become unconscious for less than a min
involuntary
not dangerous
breathing resumes after a gasp
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24
Q

what Does it increase risk of later on with BHA

A

vasovagal attacks

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25
what about pallid spells
a reflex anoxic seizure 6months -2years no epielspetic mostly due to shock or pain or sudden fright triggers including minor injury and bump on head more of a vagal reflex overactivity transient bradycardia and circulatory imapriement may or may not cry turn pale and collapse stiff>floppy less Lilkely to cry gasp as they come around traient apnoea and limpness may look grey grow out of place in recovery position pale limp unconscious --> tonic clonic phase 30-60seconds
26
management of breath holding attacks
``` eeg reassurance to parents stay calm lie child on side wartch avoid shaking don't put anything in mouth don't splash with water rest child don't punish or reward see gp and have leg after first episode esp if under 6 months or if frequent, confusion of lasting more than a min ```
27
important thing to rule out with BHA
iron deficiency
28
how many cases of epilepsy in uk
600,000
29
what is epilepsy
inappropriate signalling sensory and monitor activity is abnormal - causing activity to be disorder can be caused be infection fever syncope space occupying lesions
30
in lay man terms epilepsy
signals travel from brain to all parts of body in order to carry out activities and function in epilepsy these signals are jumbled causes repeated bursts of electrical activity in the brain symptoms include:uncontrollable jerking and shaking – called a "fit" losing awareness and staring blankly into space becoming stiff strange sensations – such as a "rising" feeling in the tummy, unusual smells or tastes, and a tingling feeling in your arms or legs collapsing
31
two categories of epilepsy
focal: locales part of brain (frontal, temporal)< usually no loss of consciousness generalised: both hemisphere involved - atonic, tonic, myoclonic, etc
32
management acute setting three crucial things. 0-5 mins
0-5 mins, ABCDE | check glucose IV access
33
what if it lasts >5 mins seizure
5-15mins same bt also LORAZEPAM or midazlam If no iV access
34
what if it lasts >25 mins seizure
phenytoin or phenarbital | if not iv access paraldehyde
35
and over 45 mins seizur
PICU and consider putting to alesp with thiopental whilst ventilated and wean slowly RARE
36
things to cover in history | seizure
``` what happened before during and after witness EEG done before video telemetry MRI advice- do not lock bathroom door at home, shower > bath helmet when cycling tell lifeguard when sweimming driving-need to be fit free ```
37
sepsis mx
LP BUFALO general cephalosporins Xray
38
what is infantile spasm
``` -repeated flexion of trunk forceful and throws arm up less steady on feet can draw or use cutlery half outgrow, half have pathology may have future seizure or DD ```
39
what would EEG show for infantile spasms
synchronous spikes
40
west syndrome
``` 350-400 in uk severe epilepsy syndrome triad of: 1. infantile spasms 2. hypsarrthmia mental retardaation ``` eeg patterns within first year attacks-> brief and infrequent
41
treatment of infantile spasms and west syndrome
IS; vigabrain, steroid, acth (3) | WS: VIAGBARITIN , COTISOCETIODS, MITRAZPAM, NA VALPORATE (4)
42
what is spina bifida?
neural tube defect
43
how does it occur spina bifid a
failure of neural tube to close in pregnancy
44
symptoms of spina bifida
lemon shaped skull (Arnold chiari malformation) tuft of hair on lower back weakness or total paralysis of the legs bowel incontinence and urinary incontinence loss of skin sensation in the legs and around the bottom – the child is unable to feel hot or cold, which can lead to accidental injury Many babies will have or develop hydrocephalus (a build-up of fluid on the brain), which can further damage the brain. Most people with spina bifida have normal intelligence, but some have learning difficulties.
45
risk factor for spina bifida
folic acid deficiency in pregnancy | fhx
46
diagnosis
tected during the mid-pregnancy anomaly scan, which is offered to all pregnant women between 18 and 21 weeks of pregnancy.
47
treatment of spina bifida
surgery soon after birth to close the opening in the spine and treat hydrocephalus therapies to help make day-to-day life easier and improve independence, such as physiotherapy and occupational therapy assistive devices and mobility equipment, such as a wheelchair, or walking aids treatments for bowel and urinary problems
48
what is muscular dystrophy
x linked autoressive condition causing abnormality to dystrophin protein
49
how does it present muscular dystrophy
motor milestone delay and sometimes mild speech delay | progressive condition
50
signs and symptoms muscle dystrophy
``` waddling lordotic gait calf hypertrophy sparing of facial and bulbar muscles muscle spasm respiration difficulty poor balance muscle wasting sclerosis inability to walk weakness to limb girdle weakness to limbs or paralysis ```
51
name a sign and what it is with muscular dystrophy
gowen sign | weakness to limb girdles
52
diagnosis of muscular dystrophy
creatinine kinease biopsy fhx
53
management of muscular dystrophy
supportive as no cure walking aids scolosis surgery physiotherapy
54
what are the subtypes of muscular dystrophy
becker same as below but later in life Duchenne-most common, boys, childhood faciospaculohumeral myotonic -2nd most common any age
55
what are tics | management
repetition of an action of phrase which causes interferences in daily life managed by guanfacine
56
what is phlagiocephaly
soft skull causing flattening of head on one side | making it look asymmetrical
57
what else can be apparent? with pahgiocqephaly
misaligned ears
58
how to prevent phlgioephaly
tummy Time don't keep in same position for too long hold both sides
59
risk factors for phaigiocelpahy
prematurity lack of amniotic fluid in prgnancy also, sleeping on back
60
what is hydrocephalus
increase in CSF volume causing dilatation of ventricles | and increases pressure in skull
61
two classifications of hydrocephalus
communicating and non comm
62
difference between two types
non comm-obstruction in ventricular system | whereas comm-reabsorption failure of CSF
63
examples of comm
subarachnoid haemorrhage | menigitis
64
non comm example
``` congenital atresia vascular malformation toxoplasmosis Arnold chiari malformation -lemons shaped skull ```
65
presentation of hydrocephalus
``` headache nausea and vomiting blurred vision sunsetting eyes papillodema bulging frontalle dysfunction at sutures dilated scalp veins rapid increase in head circumference can be seen with mumps, rubell and spina bifida later on - six nerve palsy and unstrady gait ```
66
investigations of hydrocephalus
ct mri
67
management of hydrophcephalus
shunt | or endoscopic 3rd ventriculostomy
68
what is sunsetting sign
white slecera above iris ocular globes deviated downwards upper lids retracted
69
later symptoms of hydrocephalus
high pitched cry siezures train of resp depression, hypotension and bradycardia
70
what is macwens sign
cracked pot sound on percussing head
71
give a list of types of headaches
``` raised ICP infection e.g. mengitisis analgesic hypertension dental caries sinusitis migraine eye strain tension headache ```
72
questions in hx to ask with headache
location fhx e.g. migraine OCP
73
which type can aura, halo and. zigzag lines be seen in
migraine | also throbbing
74
worse in morning or when lying down
raised ICP
75
what are focal neurological signs with headache
``` ataxia nystagmus tremor cranial nerve palsie seizures psasticity endrocrine dysfunction ```
76
describe tension headache and mx
tight bans across front at end of day normal exam reassurance and analgesia
77
migraine with aura
``` throbbing unilateral last a few hours triggers-cheese, caffeine, OCP, Alcohol, chocolate, sleep deprivation, orgasms etc aura!!!! nausea ``` rest and nalagesia pizotifen and proponalol as prophylatic
78
without aura
bilateral pulsatatile photophobia worse with eercise same management as above
79
cluster heada he
``` sudden onset unilateral perobrial pain attacks in clusters a few times a day red eye swelling around eye or tears rihoarrhea etc SUMPITRIPTAN CCCB - nIFEPIDINE ```
80
RAISEd icp
``` papillodema ataxia ofocial signs hypertension bradycardia n+v vomiting worse when lying down and localised to sign CT/.MRI treat cause ```
81
migraine is caused by
brainstem changes as it interactions with trigmeinal nerve imbalance in brain chemicals which regulars pain also serotonin drop
82
red flags in a migraine history
- short history or recent recurrent severe headache change in chracater symptoms indicating ICP riaised changes in vision and personality history of malgnonancy, neurocutenaous syndromes young age < 3y/o
83
what is most common headache type in kids
migraine | mostly genetic predisposition
84
investigations with headache
head circumference and fundoscopy | may only need future if hx od headtrauma or seizure or significant symptoms indicating for ct/mri
85
management with headache migraines
reasaurrance paracetamol and nsaids antienemtics- metoclopramide, prochlorperazine then sumatriptan prolphyatic - proponanol, piztifen na valoproate or topiramate
86
side effects of beta blockers and piztotifen
pizotifen -weight gain and sleepiness | bb- contraindicated in asthma
87
head injuries when do you admit
``` if unconsciousness no parent around suspected NAI persisting headache or vomiting evidence of skull fracture ```
88
difference between subdural and epidural injury
subdural -cresent shape | epidural - lenticular shape
89
causes of subdural haemorrhage
2ndary tp jead trauma elderly anticoagulation high fall risk patients e.g. e[ileptics
90
pathologyy presentation ix and rx
``` - tearing of veins between sinuses and may cause increase ICP and coning insidious onset consciousnesses fluctuating headache personality changes and unsteadiness ct head surgical - burr hole ```
91
extradural haemorrhage
``` 2ndary to traume fractured temporal and parietal bone following trauma to temple just lateral top eye laceration of middle meningeal vessels and blood accumulation between bone and dural lucid interval of cosuonessess headache and vomiting bradycardiaa and hypertension altered mental state drop In consciousness as icp increases hyper-reflexia xr skull and ct head lp is contridincdicated ligation of bleed ```
92
management
ct within an hour and radiology report withn an hour indications : nai post traumatic seizure -1s ttime GCS < 14 ONE OR DEPRESSED SKULL FRA CTURE FOCIAL NUEROLOGICAL DEFICITES AGED <1 WITH BURISE SWELLING OR LACERATION > 5CM ON HEAD
93
ALSO CAN BE IF MORE THAN 1 OF THE FOLLOWING IS PRESENT
``` abnormal drowsiness 3 or more discrete vomiting eispidoes dangerous mechanism -sta, fall from > 3m anmnesia witnessed loss of consciousness > 5mins ``` if only one present observe for four hours and if any other develop then do ct scan
94
seizure with face cheek twitching
``` centrotemporal spikes (BCECTS most common epilepsy syndrome in childhood. ``` outgrow the syndrome (starts) of 3–13 - a peak around 8–9 years one side of face or upper limb
95
BHA things to tell parents
not harmful no long term risks I appreciate its hard to watch as a parent, but key is to stay calm and offer reassurance to child when out of episode
96
which BHA is most common
cyanotic 85%
97
what med been found to help BHA
Piracetam even iron in absence of iDA
98
triggers for seizure
- Watching television (although watching with one eye covered presents seizures) - Lack of sleep - Flashing lights - Loud noises
99
tonic and clonic seizure
o Tonic – with sustained contraction and stiffness (from ‘tone’) o Clonic – with rhythmic jerking of one limb, one side, OR the whole body
100
symptoms if occipital affects
bright light vision changes
101
pareital
sensorimotor
102
Status epilepticus
- Technically, StE is a seizure lasting for >30 min OR repeated seizures lasting >30 min without recovery of consciousness in between
103
post iticialwhat is it and sx
After = post-ictal - Headache - Confusion - Myalgia - Temporary weakness – after focal seizure in motor cortex (Todd’s palsy) - Dysphasia – after focal seizure in temporal lobe - Sore tongue (bitten during seizure)
104
what do u need to exclude with west syndrome and what is first line mx
prednisolone tuberous sclerosis
105
most common in children type of epilepsy
⮚ rolandic benign Predominantly nocturnal sensorimotor seizures ⮚ Onset in one side of face/ a hand, then spreading down one side and may generalise
106
mx difference focal/partial and generalised
partial - carbamazepine and sodium val generalised -sodium val and lamtrogiene
107
meds for hydrocephalus
- Furosemide and acetazolamide → inhibit CSF secretion by choroid plexus - Isosorbide → promotes resorption
108
diagnostic criteria migratne w/o aura
A. At least 5 attacks fulfilling B-D B. Headache attack lasting 1-48h C. Headache has at least 2 of the following: a. Bilateral (temporal or frontal) OR unilateral location b. Pulsating quality c. Moderate-to-severe intensity d. Aggravation by routine physical activity D. During headache, at least 1 of the following: a. Nausea and/or vomiting b. Photophobia and/or phonophobia
109
migraine with aura
Idiopathic recurring disorder: headache that usually lasts 1-48h B. At least 2 attacks fulfilling C C. At least 3 of the following: a. 1/more fully reversible aura symptoms indicating focal cortical and/or brainstem and and and dysfunction b. At least 1 aura developing gradually over >4 min, or 2/more symptoms occurring in and and succession c. No aura lasting >60min d. Headache follows in <60min
110
pathological cause of plagiocepahly
the plates of the skull fusing together too early = craniosynostosis
111
diagnostic criteria four things for tics
1. Multiple motor tics AND one/more vocal tics starting <18 years 2. Presence for >1 year (may occur many times a day or be intermittent) 3. significant functional impairment 4. NOT due to drug abuse or secondary causes
112
- Echolalia
copying others words
113
- Palilalia =
repeating own words
114
coprolalia
foul words inappropriate repeated
115
copropraxia
obscene gesturees
116
echopraxia
copying others movements involuntary
117
tics severity rating
MOVES scares
118
how many are symptom free by adults with tics
1/3
119
meds for tics
``` first choice licensed halipdersol can also use risperdone ```
120
myotnic dystrophic risk with surgery
malignant hypertehermia risk increases
121
myotonic dystrophy
tent shaped mouth
122
spina bifidis back presentations
no herniation of numeral tissue with spina bifida occult spinal USS or MRI Meningocele: - Herniation of meninges and fluid only with skin covering - Rx: requires surgical closure - Prognosis: excellent prognosis :) Myelomeningocele: - Herniation of spinal neural tissue, which may be covered by meninges/skin OR be open
123
problem with myelomeningiccele
``` o Flaccid paralysis below the lesion o Urinary and faecal incontinence o Urinary tract dilatation o Hydrocephalus o Bulbar paresis secondary to Chiari malformation o Vertebral anomalies (e.g. kyphosis) ```