Neurology - 7% Flashcards
Altered Level of Consciousness / Coma
D/t systemic infx or metabolic problems or vascular events
Systemic approach to properly ID etiology and treat appropriately to prevent further damage
History and PE - neurological exam to r/o focal deficit
Consider ABC - airway, braething, circulation
- CBC, electrolyte panel, Ca. mg, phosphorus
- urine tox
- Serum ammonia
- ABG
- blood culture
- EKG and CXR
Imaging - CT scan, MRI diffusion and contrast, LP
Tx:
- Admin thiamine and dextrose
- consider naloxone for opiate OD
Alzheimer Disease
Neurocognitive disorders
Progressive cognitive decline; MC > 65yo
Sxs
- apathy
- Loss of executive fx, visual-spatial skill
- anomia - can’t remember regular name for things
- Disorientation
Dx
- abn clock drawing test
- CT scan - cerebral cortex atrophy
- beta amyloid (senile) plaques, neurofibrillary tangles (Tau protein)
Tx
- Acetylholinesterase inhibitors
- Donepezil/Aricept, Rivastigmine/Exelon, Galantamine, Tacrine
- NMDA Antagonist
- Memantine/Namenda
Arteriovenous Malformations
Abn connection btwn arteries and veins, bypassing capillary; risk of ICH & epilepsy;
MC is supratenorial
Sxs
- Seizures
- Headache
- focal neuro deficits
Dx
- Angiography - gold std
Tx
- Surgery - endovascular embolization
Bell’s Palsy
CN VII swelling - compression of nerve => hemifacial weakness/paralysis
A/w Herpes Simplex; r/o Ramsay Hunt Syndrome from Herpes Zoster
Sxs:
- URI preceding
- Acute unilateral facial weakness/paralysis - Upper and lower
- can’t raise eyebrows
- Decreased tearing
- Orbicularis m. - can’t close eyelids
- Dysgeusia - taste impairment
- Ageusia - taste loss
Dx:
- Lyme ddx
- EMG if paralysis > 10 days
Tx:
- short course of prednisone 60-80mg & acyclovir
- eye patch for corneal abrasions
- Sx decompression for CN VII
Cerebral Palsy
Neuromuscular Disorders
CNS disorder a/w muscle tone and postural abnormalities d/t brain injury during perinatal or prenatal period
Sxs
- Spasticity** - hall mark
- Intellectual/learning disabilities and developmental abnromalities
- PE - hyperreflexia, limb-length discrepancies, congenital decfects
Dx
- MRI if early suspicion
Tx
- Tx spasticity w/ Baclofen or diazepam
- braces
Traumatic Brain Injury
Closed Head Injuries
Brain dysfunction d/t outside force via violent blow to head
Sxs
- Immediate or delayed sx = change in LOC
- Personablity change
- amnesia
- increased ICP
- Diploia, posturing
Dx
- GSC
- mild - post traumatic amnesia <1 d
- mod - PTA >1 & < 7
- sev - > 7d
Tx
- golden hour emergency tx
- depends on recoveray stage of pts
- most are mild
Cluster
Headaches
middle aged Males
Sxs:
- unilateral, usually behind eye
- periorbital lacrimation
- Horner’s syndrome
- anhydrosis
- ptsosis
- miosis
- severe
- not relieved by stress- usu pacing
Dx - Brain MRI r/o maladies
Tx:
- 100% O2, 6-10L for 15 minutes
- Subcut sumitriptan
- Prophy w/ CCB - verapamil
Complex Regional Pain Syndrome
Sxs
- Preceded by direct, minor physical trauma
- Pain OOP
- disturbances of color/temp - mottled purple
- Decr ROM
- Dystrophic skin and nails
Tx - NSAIDs, prednisone, PT, antidepressants
Concussion
dx, tx
Dx:
- CT if
- +LOC
- GCS < 15
- Suspected open skull/basilar skull f
- >2 eps of vomiting
- >65 yo
- amnesia > 30 mins prior to contact
- MVA w/ ejection, pedestrian struck by car
- fall > 3 ft
- seizure
- underlying bleeding/anticoag use
- ETOH involvement
- clinical deterioration
- persistently AMS
Tx
- athletic activities resumed gradually -
- single concusion
- +LOC or sxs > 15 mins = return to sports if asymp for 1 week
- repeat concussion
- +LOC or sxs > 15 min = return next season
Concussion
eti, sxs/Grades
Transient, traumatic brain dysfunction; consciousness may be lost but patients manifest only confusion, memory loss, and gait or balance difficulties
Sxs:
- +/- brief LOC, amnesia => no structural abnormalities and no neurologic deficits
- Negative CT scan
Grade 1
- No LOC,or Post-traumatic amnesia
- other symptoms resolve < 30 mins - return to sports if asymptomatic for 1 wk
- mild TBI, GCS 13-15
Grade 2
- +LOC
- 1 minute or post traumatic amnesia that lasts > 30 min but < 1 wk
- Return to sports when asymp at rest and exertion for at least 7 days
Grade 3
- +LOC > 1 min
- post traumatic amnesia & other symp last > 1 wk
- Return in 1 mo if asymp @ rest and exertion for at least 7 days
Delirium
Neurocognitive Disorders
acute syndrome d/t med conditions, substance, intox, med w/d or SE => temporarily AMS
Sxs
- Sepsis, sundowning, ETOH or opiate w/d
- rapid onset, short term and reversible
- agitation
Dx
- disturbed LOC - decr attention or lack of env awareness
- cognitive change - memory def, language disturbance, visual illusion or hallucinations
- rapid onset w.in hrs or days
- labs, CT, or MRI
Tx - underlying cause, sedation if necessary
- haloperidol
- do not use benzo - worse in elderly
- same structure rountine every day
Diabetic Peripheral Neuropathy
Hyperglycemia -> vascular insufficiency -> nerve infarct
Sxs
- Stocking/glove distribution
- tingling, burning
- abn pain and temp sensation
- Gait imbalance - walk on rope and glass, cant feel position of feet
Dx
- N conduction study
- r/o etoh, nutritional deficient, multi myeloma, vit b12
Tx
- Anticonvuls - Pregabalin, Gabapentin, tramadol
- Tightly control blood glucose
Encephalitis
Eti - usually viral (MCC HSV, CMV if IMC)
Reye’s Syndrome - rapidly progressing encephalopathy w/ hepatic dysfx, usual post-flu/URI
- Babinski, hyperreflexia
- Aspirin/salicylate use, vomiting, confusion => seizures/coma
Sxs:
- Flu like illness
- fever, headaches, AMS
- Seizures
- Personality changes
- exanthema
Dx:
- LP and MRI
- PCR for viruses
- Kernig’s absent
- Brudzinski absent
Tx:
- Supportive care
- Acyclovir 10mg/kg IV q8hr started promptly
- Empiric abx given until bacterial mengitis r/o
Epidural Hematoma
Transient LOC from injury => LUCID => HA, unilateral weakness
traumatic IC hemorrhage after skull fracture => MC Middle menigeal artery => blood fills space btwn dura and skill
Dx
- non contrast CT - unilat convexity - lens usually temporal region => Lemon
Tx
- small - observation
- severe - surgery => burr hole, trephination, craniotomy, craniectomy
- Surgical craniotomy
- ICP management - mannitol, hyperventilate, steroids, or ventricular shunt
Essential Tremor
Movement Disorders
Bilateral tremor of hands, forearm or head; Autosomal Dominant
Sxs
- worse w/ intention (hand and head)
- better w/ alcohol
- no resting tremor
Tx
- Propanolol - if severe or situational
- Primidone (barbituate) if no relief w/ propanolol
Frontotemporal Dementia (Pick’s disease)
Neurocognitive disorders
Localized brain degeneration of frontotemporal lobes
marked personality change before memory changes
apathy, disinhibition -impulsive
Glascow Coma Scale
Score < 8 = coma or severe brain injury