Neurology Flashcards
2 types of stroke
ischaemic stroke
haemorrhagic stroke
Tool for stroke in community
FAST Tool
F – Face
A – Arm
S – Speech
T – Time (act fast and call 999)
PITS
2 parts of this are?
Parietal lobe damage causes Inferior (lower) quadrantanopia.
Temporal lobe damage causes Superior (upper) quadrantanopia.
Middle Cerebral Artery (MCA) Stroke
3 buzzwords
“Face and arm” (weakness/sensory loss)
“Aphasia” (dominant hemisphere)
“Neglect” (non-dominant hemisphere)
Like old lady on ward.
Anterior Cerebral Artery (ACA) Stroke
3 buzzwords
TACS/PACS
“Leg weakness” (contralateral)
“Personality changes” (frontal lobe)
“Incontinence” (frontal micturition center)
Posterior Cerebral Artery (PCA) Stroke
H,T,M
3 buzzwords
POCS
“Homonymous hemianopia”
(contralateral)
“Thalamic pain” (syndrome)
“Memory loss” (temporal lobe)
what part of brain is responsible for balance and walking?
Cerebellum
Area in brain for difficulty understanding speech
Wernicke’s area in the left temporal lobe of the left cerebral hemisphere.
Area in brain responsible for coordination of voluntary movements?
cerebellum
(fine tuning centre)
1° Motor cortex in frontal lobe initiates movement.
Gross motor skills issue, which part of brain?
Subthalamic nucleus
Posterior Circulation Stroke
3 buzzwords
Vertigo
Ataxia
diplopia
Long term therapy for ischemic stroke (2)
(300mg aspirin 2 weeks)
- clopidogrel 75 mg once daily
- atorvastatin 80 mg once nightly
BUT
IF AF… DOAC+ STATIN
Wallenberg’s syndrome:
4 buzzwords
Ipsilateral loss of pain and temperature on the face.
Contralateral loss of pain and temperature on the body.
Ataxia
nystagmus
Which areas are affected by a right anterior cerebral artery (ACA) stroke?
motor and sensory areas, lower limb
may cause frontal lobe deficits (personality, behavior, executive function).
basilar artery stroke
3 buzzwords
Locked-in syndrome
Dysarthria
Quadriplegia
A lacunar stroke, 3 buzzwords
clumsy hand syndrome
(dysarthria) slurred speech.
pure motor / pure sensory only
Weber’s Syndrome 3 Buzzwords:
Midbrain stroke
Oculomotor nerve palsy (“down and out” eye, ptosis)
Contralateral hemiparesis
ischemic stroke, immediate treatment (2)?
Aspirin
alteplase (Thrombolysis 4.5 hours window- or 9 HOURS WITH DETAILED IMAGING)
spinothalamic tract carries xxx and yyy sensation from the body to the brain
what are xxx and yyy
spinothalamic tract carries pain and temperature sensation from the body to the brain
and crude touch
MCA strokes affect XXX and YYY more, often involve ZZZ issues (if on the left) or neglect (if on the right).
What are XXX, YYY and ZZZ
MCA strokes affect face and arm more, often involve speech issues (if on the left) or neglect (if on the right).
ACA strokes affect the XXX more, and are often associated with YYY or ZZZ.
ACA strokes affect the leg more, and are often associated with behavioral changes or incontinence.
Posterior cerebral artery associated with what issue generally (2)
Visual issues
memory issues
Ischemic stroke , initial= CT scan
to exclude what?
Exclude Haemorrhage
Carotid stenosis test
Carotid doppler Ultrasound
stenosis Mx
Endarterectomy (70% stenosis)
Order of Brain out to in:
Skull
Dura
Archnoid mater
(Subarachnoid space)
Pia
Extradural (Epidural) Hemorrhage (EDH)
3 buzzwords
Middle meningeal artery
Lucid interval
Biconvex (lentiform) shape
Subdural Hemorrhage (SDH)
3 buzzwords
Bridging veins
Crescent-shaped on CT
Elderly/Anticoagulation
Subarachnoid Hemorrhage (SAH)
3 buzzwords
Thunderclap headache
Berry aneurysm
Blood in basal cisterns
Intracerebral Hemorrhage (ICH)
3 buzzwords
Hypertension
Basal ganglia
Focal neurological deficits
Extra dural - treatment?
Craniotomy (typically for those with larger mass effects) with ligation of artery or burrholes
Subdural - treatment?
craniotomy (typically for those with larger mass effects) (with decompressive craniectomy needed with risk of herniation) or burrholes
Subarachnoid - treatment?
clipping or
coiling (better)
Calcium channel blockers like XXX are utilized in subarachnoid haemorrhage management to forestall cerebral ischaemia caused by vasospasm.
What is XXX
Nimodipine
MINOR bleed: WWW
MAJOR bleed: XXX
NOT bleeding:
INR >8: YYY
INR 5-8: ZZZ
MINOR bleed: WWW IV vitamin K
MAJOR bleed: XXX IV vitamin K + prothrombin complex concentrate
NOT bleeding:
INR >8: YYY oral vitamin K
INR 5-8: ZZZ miss next dose of warfarin
Haemotoma Hyper-dense CT: tell me about it
Haemotoma Hypo-dense CT: tell me about it
Hyper-dense: Acute haematoma and bright in colour
Hypo-dense: Chronic haematoma and dark in colour
XXX, YYY - ACUTE MANAGEMENT cluster headaches
AND
ZZZ - PROPHYLAXIS
cluster headaches
XXX,YYY sumatriptan, high flow oxygen (100%)
ACUTE MANAGEMENT cluster headaches
AND
ZZZ verapamil - PROPHYLAXIS
Good acronym for haemorrhagic stroke management
A -
B -
C -
Good acronym for haemorrhagic stroke management
A - anticoagulant reversal
B - BP control
C - Consider neurosurgery
Male/Female 40-60 age
stiffneck
Photophobia
Sudden severe occipital headache
Which disease?
subarachnoid hemorrhage
THUNDERCLAP HEADACHE
3 reasons why people get subarachnoid hemorrhage?
- Illicit Drug use
- Blood conditions (Sickle cell)
- Kidney issues
1st line Ix Subarachnoid Hemorrhage
and 2nd line
Non-Contrast CT HEAD
then
L.P ( ↑ RBC)
(Pink/ Yellow) Xanthochromia
Medication to prevent vasospasm after SAH
Nimodipine
Female
20-40 age
Epstein-Barr virus
↓ Vit D
Which disease?
Multiple Sclerosis
disease linked with M.S a lot
Optic Neuritis
3 types of Disease patterns for M.S
Relapsing Remitting (most common)
Secondary Progressive
Primary Progressive
MS Ix (2)
MRI
L.P
Finding in CSF in MS
Oligoclonal bands
MS Tx
Methylprednisolone
Age 50-70
Male
gradual onset weakness (hands / shoulders)
No sensory symptoms
Which disease?
Motor Neurone Disease
Most common MND
AMYLOTROPIC LATERAL SCLEROSIS
Meds for ALS/MND
riluzole
UMN or LMN sign: LMN or UMN
fasciculations
Brisk Reflexes
Upgoing plantars
Muscle Wasting
Spasticity
fasciculations LMN
Brisk Reflexes UMN
Upgoing plantars UMN
Muscle Wasting LMN
Spasticity UMN
Primary lateral sclerosis (PLS): UMN or LMN?
progressive UMN degeneration,
spasticity
hyperreflexia
weakness
without muscle atrophy or fasciculations.
Spinal Muscular Atrophy (SMA)
UMN or LMN?
LMN
degeneration of LMNs
muscle atrophy
weakness
fasciculations without spasticity or hyperreflexia.
Progressive bulbar palsy - affects what?
primarily affects the muscles of talking and swallowing (the bulbar muscles).
Male, 60-65 years
Resting tremor
Rigidity
Bradykinesia
Which disease?
Name of Facial masking in Parkinson’s
Hypomimia
Multiple System Atrophy (MSA):
(Parkinson’s)
3 buzzwords
Autonomic dysfunction – Postural hypotension, urinary incontinence.
Cerebellar ataxia – Coordination problems.
Parkinsonism – Tremor, rigidity, bradykinesia (poor response to levodopa).
Hot Cross Buns
Dementia with Lewy Bodies (DwLB):
(Parkinson’s)
3 buzzwords
Visual hallucinations – Common early symptom.
Fluctuating cognition – Varying levels of alertness and attention.
REM sleep disorder – Acting out dreams (early feature).
1st line Tx Parkinson’s
Levodopa with
Carbidopa
or
Benserazide
3 examples of Dyskinesias (Parkinsons)
Dystonia: Sustained, abnormal postures or twisting movements.
Chorea: Sudden, unpredictable, jerky movements.
Athetosis: Slower, writhing, snake-like movements.
a COMPT inhibitor, link to Parkinsons? What name of drug
Entacopone
inhibits COMT enzyme, increasing dopamine availability
a Dopamine Agonist (parkinsons)
Bromocriptine
is a dopamine D2 receptor agonist, reducing prolactin secretion
Mao-B inhibitor (2)
(parkinsons)
Selegiline and rasagiline are both selective MAO-B (monoamine oxidase-B) inhibitors.
3 key reasons to think Benign Essential Tremor (BET) over Parkinson’s disease:
- Tremor with action – BET occurs during movement, while Parkinson’s tremor is usually at rest.
- Symmetrical tremor – BET typically affects both sides equally, while Parkinson’s often starts asymmetrically.
- Lack of bradykinesia or rigidity – BET lacks the slowed movements and muscle stiffness seen in Parkinson’s disease.
Treatment for BET (2)
Propanolol
Primidone
Non-epileptic seizures, key thing to remember
remembers the entire event clearly
Tonic-Clonic seizure (Grand Mal) (3)
Loss of consciousness
Muscle tone stiffening and rigidity
Clonic phase, Rhythmic jerking or convulsions.
bonus= post ictal period
Absence seizure (Petit Mal) (3)
Staring spells: Sudden, brief episodes of staring or blank expression.
No postictal confusion: The person resumes normal activity immediately after.
Children: More common in pediatric populations.
Myoclonic seizure (3)
Sudden jerks: Quick, involuntary muscle twitches.
No loss of consciousness: The person remains aware during the jerks.
Morning onset: Often occurs shortly after waking.