Neurological Presentations Flashcards
Define SEIZURE.
A seizure is a rapid and irregular firing of neurons within the brain, leading to abnormal electrical activity.
In children, seizures are of two main types:
- afebrile
- febrile
Define FEBRILE SEIZURE.
A febrile seizure is a seizure that occurs in a child, typically between 6 months to 6 years, in the context of a febrile illness (e.g. gastroenteritis, URTI, UTI).
Define AFEBRILE SEIZURES.
An afebrile seizure is a seizure that occurs in a child in the absence of a fever.
Describe key characteristics of FEBRILE SEIZURES.
✔️ key age is between 6 months to 6 years
✔️ benign
✔️ very common in normal, healthy children
✔️ risk of going on to develop epilepsy is 1% (if no other risk factors are present)
✔️ risk of recurrence is 50% in the first 12 months and 30% in the second twelve months
Outline the diagnostic criteria for the different types of febrile seizures:
- simple febrile seizure
- complex febrile seizure
- afebrile febrile seizure
SIMPLE FEBRILE SEIZURE
Presence of a fever plus ALL of the following:
✔️ generalised tonic-clonic seizure
✔️ seizure duration < 15 minutes
✔️ complete recovery within 60 minutes
✔️ only a single seizure occurs within the one disease episode
COMPLEX FEBRILE SEIZURE
Presence of a fever plus at least ONE of the following:
✔️ focal neurological deficit either during or after the seizure
✔️ seizure duration > 15 minutes
✔️ recovery takes longer than 60 minutes
✔️ multiple seizures within the one disease episodes
AFEBRILE SEIZURE
✔️ symptoms consistent with febrile seizure, however, NO fever present
Outline some differentials for SEIZURE in a child, that must be considered when taking seizure history.
✔️ febrile seizure –> presence of fever (e.g. gastro, UTI, URIT), generalised tonic-clonic, duration < 15 mins, recovers within 60 mins
✔️ epilepsy –> previous seizure episodes; previous diagnosis
✔️ head trauma
✔️ meningitis –> fever, rash, headache, lethargy, sepsis
✔️ encephalitis –> fever, rash, headache, altered consciousness
✔️ hypoxia
✔️ malignancy –> headache, nausea, projectile vomiting
✔️ stroke –> ongoing neurological deficits
✔️ hypoglycaemia / hyponatremia –> missed meals, dehydration
Outline appropriate investigations for SEIZURE in a child.
Bedside Ix
✔️ urine dipstick + MCS
✔️ blood glucose level
✔️ ECG (to check for electrolyte abnormalities)
Laboratory Ix ✔️ FBC + WCC ✔️ Inflammatory markers ✔️ UECs ✔️ Blood culture ✔️ Lumbar puncture (only if meningitis / encephalitis suspected) --> contraindicated if raised ICP
Imaging Ix
✔️ non-contrast brain CT
EEG is usually NOT required for the diagnosis of febrile seizures in children.
Define BRIEF UNEXPLAINED RESOLVED EVENT (BRUE).
A BRUE is an episode that occurs in a child < 12 months of age in which there is reduced tone, changes to colour (e.g. pallor, cyanosis), reduced breathing and / loss of consciousness which lasts for < 60 seconds, resolves spontaneously and cannot be attributed to an underlying cause.
Describe key features of BRUE.
✔️ occurs in a child < 12 months of age ✔️ lasts < 60 seconds ✔️ spontaneous recovery and return to baseline ✔️ no underlying medical cause found ✔️ characterised by at least ONE of the following: 1. cyanosis / changes to colour 2. abnormal / reduced breathing 3. hypotonia 4. loss of consciousness
Identify factors that characterise a LOW RISK BRUE.
✔️ child age > 60 days ✔️ child born at least 32 weeks gestation or is at least 45 weeks corrected age ✔️ first episode ✔️ duration < 60 seconds ✔️ no CPR required
Low risk BRUE does not require admission to hospital. If the parents wish for admission for one night to allow for observation, this is acceptable.
Define CEREBRAL PALSY.
Cerebral palsy is the consequence of a non-progressive brain lesion / insult that results in a permanent deficit in movement or posture.
What are some risk factors for CEREBRAL PALSY?
✔️ extreme prematurity ✔️ IUGR ✔️ placental abnormalities ✔️ thrombophilia ✔️ significant hypoxic event (e.g. birth trauma, trauma) ✔️ RhD or ABO incompatibility ✔️ maternal infection (e.g. TORCH infections) early in pregnancy ✔️ severe jaundice
Outline ways in which CEREBRAL PALSY may present in a child.
- Follow up of high-risk infants (e.g. extreme prematurity, neonatal encephalitis / meningitis, congenital hydrocephalus)
- Concerns with development; developmental delay (e.g. unable to sit by 6 months, trouble standing at 12 months, unable to walk by 18 months)
- Abnormal tone (hypotonic initially, progresses to hypertonia)
- Persistent primitive reflexes (e.g. Moro reflex, grasp reflex)
- Early hand preference / asymmetrical movements
- Severe feeding problems or prolonged irritability
Identify some common complications of CEREBRAL PALSY.
✔️ vision and hearing problems
✔️ speech and language problems
✔️ cognitive impairment
✔️ seizures (~50%)
✔️ recurrent respiratory tract infection –> chronic lung disease
✔️ aspiration –> aspiration pneumonia
✔️ gastrointestinal problems (e.g. GOR, GORD, constipation)
✔️ hip displacement (subluxation )
✔️ knee contracutres
✔️ increased osteoporosis and fracture risk
✔️ poor dentition
Equinis deformity of the foot