Neurological Disorder Pharmacology Flashcards

1
Q

What symptoms are treated in Huntington’s disease with drugs?

A
  1. Chorea

2. Psychiatric symptoms

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2
Q

What drugs treat chorea in HD?

A
  1. Tetrabenazine - depletes dopamine in cerebrum
  2. Neuroleptics - dopamine blocker
  3. Benzodiazepenes - CNS depressant
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3
Q

What drugs treat psychiatric symptoms in HD?

A
  • same as used for general population
    1. Depression - SSRIs
    2. Psychosis and behavioral - atypical antipsychotic drugs
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4
Q

What drugs treat dystonia?

A
  • condition of BG; drug depends on patient
    1. Levodopa (relieves sx, not cure)
    2. Diazepam (muscle relaxants)
    3. Anti-muscarinic agents
    4. Baclofen - GABA B agonist
    5. BOTOX
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5
Q

What are the muscarinic antagonists?

A
  1. Benztropine

2. Diphenhydramine – also histaminergic blocker (For acute dystonic reaction; knocks down bad m contraction)

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6
Q

What is the first action to treat neuropathy?

A

Address the cause

  • diabetes - control sugar levels
  • immune - treat
  • vitamin deficiencies - treat
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7
Q

Block metabolism of glucose to sorbitol which can cause osmotic damage to nerves and the lens of the eye; prevents diabetic polyneuropathy

A

Aldol reductase inhibitors

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8
Q

What is used to treat pain related to polyneuropathy

A
  1. Traditional analgesics (affects perception of pain)
  2. Antidepressants - acts on CNS
  3. Anti-seizure medications
  4. Clonidine - presynaptic receptors
  5. Oral cannabinoids
  6. NMDA antagonists - acts on CNS
  7. Treatment for sympathetic hyperactivity
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9
Q

Neuropathic pain can often be diminished by traditional analgesics, but often not eliminated; recommended for patients with sensitized C-nociceptors

A

Opioids

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10
Q

What are the treatments for sympathetic hyper activity?

A
  • drugs that block sympathetic fxn
    1. Norepinephrine blockade with clonidine
    2. Ganglion block with lidocaine, a local anesthetic
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11
Q

What are the psychiatric disorders that most often occur in ASD and are treated with drugs?

A
  • ASD does not have any drugs to treat disease
    1. Anxiety (antidepressants, anti anxiety)
    2. ADHD (stimulants)
    3. OCD
  • antipsychotic agents can help with sleeplessness
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12
Q

Pain associated with diabetic neuropathy, postherpetic neuralgia, polyneuropathy, and nerve injury associated with cancer; Effect usually at lower doses than for the anti-depressant effect; Can also relieve other symptoms such as sleep problems Newer SSRI’s are less sedating, but also effective in chronic pain

A

antidepressants in neuropathic pain

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