Neuroleptic malignant syndrome Flashcards
1
Q
What is the pathophysiology of NMS?
A
Systemic dopamine deficit usually due to antipsychotic dopamine blocking drugs eg haloperidol, chlorpromazine, prochlorperazine, metoclopramide
2
Q
What are the symptoms of NMS?
A
1) altered GCS
2) autonomic instability
3) Muscle rigidity (parkinsonism)
4) high temp
3
Q
How can NMS be differentiated from serotonin syndrome?
A
-greater degree of muscle rigidity and less common to have hyperreflexia
-slower onset
-can progress to severe encephalopathy, rhabdo & MOF
4
Q
A
5
Q
How do you manage NMS?
A
Supportive measures
I&V - if low GCS
CVS support
Fluids
Coolling
Stop causative drug
May need EEG to r/o NCSE
