Neurohormonal Control

Question 1

What is the difference between low dose and high dose epi?

Answer 1

Epi has a greater affinity for B-adrenoreceptors than alpha—> (but stimulates both B and A)

** At low doses epi binds preferentially to b-adrenorecepors—causing increase in HR, inotropy, and dromotropy while causing vasodilation

** higher concentrations of epi—> further increase in HR, inotropy, chronograph and now cause vasoconstriction