NeuroHist Flashcards
Electrical hypothesis (intrinsic electrical activity)
Luis Galvani
Localization of function
Broca
Motor Cortex identified
Ferrier
Silver stain
Golgi
Singular unit of CNS = individual nerve cells
Santiago Ramon y Cajal
“synapse”
Sherrington
Began Neurocentric Age
Thomas Willis
All or nothing principle
Adrian
Nerve growth factors
Levi-Montalcini
Microglia in white matter
Serra
NTs!
Loewi
Criteria to determine whether a NT
- Chemical synthesized and stored in presynaptic neuron
- released and produces response in target cell
- Same response on target cell when added experimentally
- Must be mechanism for removing from site of action
What enzyme does Ca++ bind to to stimulate TH activity
Calmodulin
Rate limiting factor for catecholamines
TH (converts tyrosine to DOPA)
Rate limiting factor for serotonin
Tryptophan
PNMT converts…?
Converts NE to epinephrine
Neurocentric history by century
17th Thomas Willis - behavior brain correlation, making brain parts
18th Luis Galvani - intrinsic electrical activity, necessary for movement
19th Paul Broca - functional localization in brain
20th turn - Santiago Ramon y Cajal - neuron doctrine
Neuron Doctrine
Individual neurons are the singular unit of the nervous system
Nervous system is made up of discrete individual cells: neurons.
Author and date of diversity paper
Harrington, 2021 (Nathan???)