neurogenetic disorders

Question 1

modes of inheritance of neurogenetic disorders

Answer 1

• autosomal dominant
• autosomal recessive
• x-linked recessive
• mitochondrial
• triplet repeat diseases (anticipation)

Question 2

poly-Q ((polyglutamine) diseases

Answer 2

• CAG repeats
• e.g. huntingtons disease (AD)
• inherited cerebellar degenerations (the spinocerebellar ataxias)