neurodevelopment Flashcards
1
Q
6 stages of brain development
A
- cell birth/proliferation
- cell migration
- cell differentiation and maturation
- synaptogenesis and synaptic pruning
- cell deat
- myelination
2
Q
cell birth/proliferation
A
neurogenesis and gliogenesis
- peak = 250,000 neurones born/minute
- initially neural tube is one cell thick –> lots of cell division = cells hold on as the tube expands
- no division in neurogenesis - neurones do not divide
- stem cells divide to form precursor cells which can be neuroblasts OR glioblasts
3
Q
ventricular zone
A
- inner surface of neural tube
- layer that produces neurones
- cells undergoing mitosis also closer to here
4
Q
cell migration
A
- newly formed cells move to the outer layers
- cortex develops in an inside out manner
- primitive map of the cortex that predisposes cells born in a certain region to migrate to a specific cortical region
occurs with the help of:
- chemical signals (immunoglobulins and cytokines)
- physical support (radial glia)
neurones follow a specific pattern INSIDE OUT - without specific brain layering = impact
5
Q
2 mechanisms that support cell migration
A
- chemical signals (immunoglobulins and cytokines)
- physical support (radial glia)
6
Q
A