Neurodegenerative disorders

Question 1

name the disease that is caused by amyloid beta peptide plaques in extracellular brain tissue. the disease is marked by loss of memory, cognitive function and language. this disease. 95% of cases are sporadic form

Answer 1

Alzheimer’s Disease

Question 2

name the disease that is caused by alpha synuclein proteins forming insoluble fibrils which deposit as Lewy bodies in dopaminergic neurons which reduces the availability of dopamine which causes impairment of fine motor skills

Answer 2

Parkinson’s disease

Question 3

name the disease that is from a gene mutation that results in CAG repeats that results in polygluamine repeats in HTT protein that misfolds and aggregates. Death of basal ganglia cells cause the symptoms which include: loss of movement, cognitive function and psychiatric problems

Answer 3

Huntington’s Disease

Question 4

name the disease that is caused my misfolding of prion proteins, this is transmissible “infection” that misfolds normal proteins in the brain

Answer 4

Creutzfeldt-Jakob disease

Mad cow disease