neurodegenerative diseases: hyperkinesia types, structure of basal ganglia, parkinsons, huntingtons

Question 1

types of hyperkinesia

Answer 1

1. chorea ( dance like )
2. athetosis ( slow snake like )
3. resting tremor
4. intention tremor
5. hemibalismus ( ball like limb movements)

Question 2

structures of basal ganglia ?

Answer 2

thalamus
subthalamic nuclei
substantia nigra
caudate nucleus
putamen
globus pallidus

Question 3

huntington: type of genetic disorder?

Answer 3

autosomal dominant

Question 4

huntington: localisation ?

Answer 4

neurodegeneration of GABA neurons in caudate nucleus and putamen in the basal ganglia

Question 5

huntington: mutation in what gene ( and what is observed according to this mutation )

Answer 5

mutation of HTT gene ( huntingtin protein) on chromosome 4
triplet repeat > 36
increase in glutamine

Question 6

huntington: age of onset

Answer 6

40

Question 7

huntington: types of hyperkinesia present

Answer 7

chorea
athetosis

Question 8

huntington: sx ?

Answer 8

depression
personality changes
aggression
dementia
speech problems
abnormal eye movements
poor coordination

Question 9

huntington: are these sx present all the time ? . m