Neurocognitive Disorders Flashcards
Neurocognitive Disorders
These are disorders in which a clinically significant deficit in cognition or memory exists, representing a significant change from a previous level of functioning
what is age risk for dementia
middle age and beyond
what is delirium
A disturbance in level of awareness and change in cognition
How quick does Delirium develop
rapidly over a short period
what are the symptoms of delirium
- Difficulty sustaining and shifting attention
- extreme distractibilty
- disorganized thinking
- speech that is rambling, irrelevant, pressured
- Impaired reasoning ability and goal-directed behavior
- disorientation to time and place
what are the symptoms of delirium
- impairment of recent memory
- misperceptions about the environment, including illusions and hallucinations
- disturbance in level of consciousness, interruption of wake and sleep cycle
- fluctuates between agitation and restlessness and vegetative state
- emotional instability
Delirium autonomic Symptoms
tachycardia sweating flushed face dilated pupils elevated blood pressure
delirium duration
usually brief and subsides completely on recovery from underlying determinant
Substance-induced delirium
maybe cause by intoxication or withdrawal from certain substance
- Anticholinergics, antihypertensives, corticosteroids
- alcohol, amphetamines, cannabis, cocaine, hallucinogens
- toxins, solvents, fuels, lead, mercury, arsenic, carbon monoxide
Neurocognitive disorder
impairment in the cognitive functions of thinking, reasoning, memory, learning, and speaking
Two classes of NCD depending on serverity
- Mild NCD also known as mild cognitive impairment
- Major NCD constitutes what was previously described in the DSM as dementia
Primary NCDs
disorder itself is the major sign of some organic brain disease not directly related to any other organic illness(Alzheimer disease)
Secondary NCDs
are caused by or related to another disease or condition (HIV DISEASE, CEREBRAL TRAUMA)
NCDs symptoms
- Abstract thinking, judgement, and impulse control
- conventional rules of social conduct are disregarded
- Personal appearance and hygiene are neglected
- Personality change is common
Reversible NCD (temporary dementia) is caused by ?
Stoke depression side effects of medications Nutritional deficiencies metabolic disorders
NCD symptoms
Aphasia- cannot speak at all
Apraxia- inability to carry out motor activities
Irritability and moodiness, sudden outburst
Inability to care for personal needs independently
Wandering away from home
Incontinence
Alzheimer’s disease (AD)
Accounts for 50 to 60% of all cases of NCD
Alzheimer’s disease Stage 1
No apparent symptoms
Alzheimer’s stage 2
Forgetfulness
loose things/forget names of people
Alzheimer’s stage 3
Mild cognitive decline
Inference with work performance that is noticeable
get lost when driving car
decline ability to plan or organize
Alzheimer’s stage 4
Mild to moderate cognitive decline
-shopping/ personal finances
-forget major events in history-childs birthday
Confabulation- creating imaginary events to fill the memory gaps
Alzheimer’s stage 5
Moderate cognitive decline
- forget addresses, phone numbers, place and time
- loose ability to perform ADL
Alzheimer’s stage 6
Moderate to severe cognitive decline -forget name of spouse -forgot day, season, year sundowning can't remember major life events
Alzheimer’s stage 7
Severe cognitive decline
-end stages
unable to recognize family ,members
immobility, contractures
Onset of Alzheimer’s (AD)
- Onset is slow and insidious
- course is generally progressive and deteriorating
NCD due to Alzheimer’s Disease AD
The enzyme used to produce acetylcholine alterations is drastically reduced
Etiologies of AD
Over abundance in the brain of plague and tangles
plaques: are protein (amyloid beta)
Tangles: are formed from a special protein tau protein whose function provide stability
risk of AD
History of head trauma makes them a higher risk
Alzheimer’s genetic factors
40% have a family history
Vascular NCD
NCD occurs as a result of significant cerebrovascular disease
Vascular NCD onset
More abrupt onset than is seen in association with AD, and the course is more variable