Neurocognitive Disorders

Question 1

Name, pathophys, and DDx of gait with feet sliding along the floor, not lifting feet with each step?

Answer 1

“magnetic gait”, associated with damage to periventricular white matter, most common causes are normal pressure hydrocephalus and subcortical microvascular disease

Question 2

Pathophys and DDx of wide-based gait?

Answer 2

associated with damage to the cerrebellum, common causes are alcoholism and Wernicke’s encephalopathy

Question 3

Name, and DDx of gait with hunched, small, stuttering steps, and often also with difficulties at transitions (doorways, changes in flooring)?

Answer 3

“festinating gait”, associated with dopamine dysfunction and seen in Parkinson’s disease and patients with extrapyramidal symptoms

Question 4

Protein aggregates in Alzheimer’s Disease?

Answer 4

Amyloid and Tau

Question 5

Protein aggregates in Down’s Syndrome?

Answer 5

Amyloid and Tau

Question 6

Protein aggregates in Parkinson’s Disease

Answer 6

Alpha-Synuclein

Question 7

Protein aggregates in neurocognitive disorder with Lewy Bodies?

Answer 7

Alpha-Synuclein

Question 8

Protein aggregates in Multiple system atrophy?

Answer 8

Alpha-Synuclein

Question 9

Protein aggregates in chronic traumatic encephalopathy?

Answer 9

Highly-phosphorylated Tau

Question 10

Protein aggregates in Pick’s Disease

Answer 10

Tau

Question 11

Protein aggregates in Progressive supranuclear palsy

Answer 11

Tau

Question 12

Protein aggregates in cortiobasal degeneration?

Answer 12

Tau

Question 13

Protein aggregates in FTDP-17

Answer 13

Tau