Neuroblastoma Flashcards
1
Q
What is the system of origin in a neuroblastoma?
A
A solid tumour developing from the developing sympathetic nervous system.
It is an embryonal neoplasm and therefore is seen in early childhood.
2
Q
What are the typical signs and symptoms of a neuroblastoma?
A
Majority of symptoms and signs occur either due to the mass effect of the tumour or as a result of metastases.
Symptoms: Weight loss. Fatigue. Anorexia. Diahorrea.
Signs:
Hepatomegaly
Hypertension due to pressure on renal aa.
3
Q
What gene is associated with Neuroblastomas?
A
The Oncogene: MYCN
Amplification of the MYC protein is seen 25% cases and correlates with a poor prognosis.
