Neurobiology Flashcards
What did scientists initially believe about neurons?
Axon of one cell fused with the dendrites of another, in an uninterrupted connection
What is a synapse and how were they discovered?
- Meeting point between neurons
2. Founded by Sir Charles Sherrington because neural impulses were taking unexpectedly too long
What is the synaptic gap?
Junction between the axon tip of the sending neuron and the dendrite or cell body of the receiving neuron
What are neurotransmitters?
- Chemical messengers cross the synaptic gap between neurons
- Neurotransmitters bind to receptor sites and influence whether the neuron will generate an impulse
What is reuptake?
Neurotransmitter’s re-absorption by the sending neuron
What 2 other things can happen to excess neurotransmitters?
They can drift away or be broken down by enzymes
What did Pert and Synder discover?
- Our bodies produce naturally occurring opiates
2. Endorphins produce painkilling and high-like effects
What are agonists?
- Molecule that increases a neurotransmitter’s action
- Increases production or release or blocks reuptake
- Can act like a neurotransmitter and binds to sites by mimicking excitory or inhibitory effects
What are antagonists?
- Chemical that decreases a neurotransmitter’s action by blocking production or release
- So similar to neurotransmitters that they can block receptor sites though not similar enough to stimulate
What is glutamate?
- Excitory Neurotransmitter linked to learning
- Most abundant
Oversupply - migraines, seizures, stroke
Deficiency - insomnia, low energy, lack of concentration
What is GABA?
Inhibitory neurotransmitter that counteracts norepinephrine by reducing stress
Deficiency - anxiety disorders, seizures, and insomnia
What are endorphins
Inhibitory neurotransmitter/hormone linked to pleasure and pain
Oversupply - the brain stops producing natural endorphins
What is dopamine?
Excitory or inhibitory neurotransmitter that influences movement, learning, attention, and pleasure
Oversupply - schizophrenia (antagonist)
Deficiency - Parkinson’s (agonist)
What is serotonin?
Inhibitory neurotransmitter affects mood, hunger, sleep, and arousal
Deficiency - depression, sleep-awake disorders, food rcravings, and agression
What is norepinephrine?
Excitory neurotransmitter which controls alertness and arousal; increases heart rate and blood pressure in a flight or fight response
Oversupply- Agitated states and mania
Deficiency - Depression
What is ACH (Acetylcholine)?
Excitory nerotransmitter that enables muscle action, learning and memory
Botulin blocks Ach causing paralysis (botox)
What did Plato and Aristotle believe about the human mind?
Plato successfully located the mind in the head whereas Aristotle believed that the mind was in the heart
What did phrenology succeed in doing?
Franz Ggall’s speculations were correct in assuming that there are different parts of the brain that control aspects of our behavior
Within the past century, what have scientists discovered about the biology of the mind?
- Nerve cells conduct electricity and communicate to each other by sending chemical messages
- Specific brain systems serve specific functions
- We integrate information in different parts of the brain to construct our experiences of sights and sounds
- Our adaptive brain is wired by experience
What does phrenology and psychology’s biological perspective have in common?
They share a focus on the links between the brain and behavior
What is the function of a neuron?
A neuron is a nerve cell; the basic building block of the nervous system
What are neurons composed of?
- Each consists of a cell body and short branching fibers, called dendrites that receive messages and conduct impulses
- Long axons pass messages through terminal branches to other neurons, muscles or glands
- Dendrites listen, axons speak
What is the myelin sheath and what occurs if it degenerates?
- Myelin sheath is a layer of fatty tissue that insulates and speeds impulses
- As myelin is laid down up to age 25, neural efficiency, judgement, and self control grow
- If it degenerates multiple sclerosis can occur wherein communication to muscles slow
How are nerve cells supported?
Glial cells provide nutrients, insulating myelin, guide neural connections, and mop up ions and neurotransmitters
What is action potential?
A neural impulse; a brief electrical charge that travels down an axon
How quickly can a neural impulse travel?
2 miles per hour to more than 200 miles per hour
How are batteries and neurons similar to each other?
They both generate electricity from chemical events
What is resting potential and how is achieved?
Fluid outside of axon has positive charged sodium ions whereas the interior has mostly negatively charged potassium ions. This positive/negative state is resting potential
What makes an axon selectively permeable?
- The axon is selective about what it allows through, therefore making the surface selectively permeable
- Sodium ions can get inside through the Nodes of Ranvier and set things into motion
What occurs when a neuron depolarizes?
Depolarization occurs when a neuron fires, the first section of the axon opens its gates and positively charged sodium ions flood the cell membrane leading to a loss in the inside/outside charge difference which triggers a chain reaction
What will happen if the level of stimulation is pushed above the threshold of a neuron?
- Most signals are excitory whereas some are inhibitory. If excitory signals exceed inhibitory signals by a minimum threshold, the signals trigger an action potential
- Increasing stimulation above threshold will not increase the neural impulse’s intensity because the neuron’s reaction is all-or-none
How does a nervous system allow us to distinguish between a slap and a tap on the back?
Stronger stimuli (the slap) cause more neurons to fire and to fire more frequently than happens with weaker stimuli (the tap).
What is the direction of impulse in neurons?
Dendrites to cell body then to axon terminals
What is Action Potential #1?
Stimulation causes the cell body to set things into motion
What is Action Potential #2?
- The Nodes of Ranvier along the myelin sheath open and let sodium ions, which depolarizes the atoms inside the axon, creating an electric charge
- Depolarization has to reach -55mV
What is Action Potential #3?
An electrical charge is sent from node to node down the axon, pushing neurotransmitters out of the axon terminals