Neuroanatomy - Brain Flashcards
Where does CN 1 exit skull
(olfactory nerve) - cribiform plate
Where does CN 2 exit skull
(optic n) - optic canal
Where does CN 3 exit skull
(oculomotor) - superior orbital fissure
Where does CN 4 exit skull
(trochlear) - superior orbital fissure
Where does CN 5 exit the skull
Trigeminal Vi - superior orbital fissure Vii - foramen rotundum Viii - foramen ovale (standing room only)
Where does CN 6 exit the skull
(abducens) - superior orbital fissure
Which CNs exit the superior orbital fisure?
CN 3-6 (Vi only)
Where does CN 7 exit the skull?
Facial - internal acoustic (auditory) meatus —> stylomastoid foramen
Where does CN 8 exit the skull?
Vestibulocochlear (auditory) n - internal acoustic meatus (doesnt exit skull)
Where does CN 9 exit the skull?
Glossopharyngeal N - jugular foramen
Where does CN 10 exit the skull
Vagus - Jugular foramen
Where does CN 11 exit the skull
Spinal accessory n - jugular foramen & foramen magnum
Where does CN 12 exit the skull
Hypoglossal N - hypoglossal canal
Through which opening do the middle meningeal arteries pass?
Foramen spinosum
Through what hole do the internal carotid arteries pass?
carotid canal
Through what hole do the vertebral arteries pass?
Foramen magnum
Name the 3 meninges
Dura, arachnoid, pia
What comprises the dura meninges
2 tough fibrous layers (periosteal, meningeal)
Falx Cerebri
Tentorium Cerebelli
What comprises the arachnoid meninges
Wispy layer adhering to inner dura
CSF
What comprises the pia meninges
Thin layer of cells
Adheres closely to surface of the brain
Along all gyri/ into sulci
Surrounds blood vessels as it penetrates
brain surface, then fuses with blood vessel
wall
Bi-uncal herniation could result in:
Why?
PCA infarct
Vertebral arteries enter via foramen magnum
Name the 4 types of herniation
Transtentorial
● Uncal
● Subfalcine
● Tonsillar
Branches of external carotid (in order)
Some Anatomists Like Freaking Out Poor Medical Students ● •S- superior thyroid artery ● •A- ascending pharyngeal artery ● •L- lingual artery ● •F- facial artery ● •O- occipital artery ● •P- posterior auricular artery ● •M- maxillary artery ● •S- superficial temporal artery
(Blood supply to the thyroid, larynx, salivary glands, tongue, nose, lips, chin, palate, neck, face, ears, and lower portion of
the skull.)
anatomy of circle of willis
ACA A Comm Internal Carotid MCA P Comm PCA Superior Cerebellar Art Basilar Artery Ant Inf Artery Post Inf Artery Vertebral Artery Anterior Spinal Artery
PCA supplies:
Inferior/Medial Temporal Lobe and Occipital Cortex
ACA supplies:
Most of anterior medial surface frontal to parietal lobes including sensorimotor cortex
MCA supplies:
Superior Division: Above Sylvian Fissure including lateral frontal lobe
Inferior Division: Below Sylvian Fissure including lateral temporal lobe, variable
parietal lobe
Which arteries supply BG
Lenticulostriate arteries from A1 (occasionally) and M1; often source of BG hemorrhage from HTN
Penetrating Vessels at Base
Arise from initial MCA
Supply basal Ganglia & Internal capsule
Describe venous drainage from the brain
Superficial Veins: Superior Sagittal Sinus and
Cavernous Sinus
Deep Veins: Vein of Galen
Internal Jugular Vein
SAH blood contained where?
Located between Arachnoid
and Pia
Most common site of aneurysmal SAH
Other causes of SAH? (5)
ACA, anterior circ
Saccular=Berry Aneurysm
● Other:Arteriosclerotic, Mycotic,
Dissecting, Traumatic, Neoplastic
Describe the ventricle system
2 lateral ventricles Foramen Monro 3rd Ventricle (Thalamus, Hypothalamus) Cerebral Aqueduct (Midbrain) 4th Ventricle (Pons, Medulla, Cerebellum) Foramen Magendie, Foramina Luschka Cisterna magna Prepontine Cistern
CSF
- produced by _______
- Passes from ventricular system through ____.
- Reabsorbed by _____
- Drained by _____
produced by Choroid Plexus
Passes from ventricular system through Foramina
Reabsorbed by arachnoid granulations
Drained by Dural Venous Sinuses
CSF volume: ____ (adult)
Produced at what rate? ____ per hour, _____ per day
Volume: 150ml (adult)
Produced at 20ml/hour (500ml/day)
Three times of hydrocephalus
Communicating
Non-communicating
E Vacuo
Most common cause of communicating hydrocephalus
decreased CSF absorption
Describe brain hierarchy
Brain Stem (Mid Brain, Pons, Medulla Oblongata) Cerebellum Thalamus Limbic System Cerebral Cortex
Midbrain comprised of which CNs?
CN II/III/IV
Pons comprised of which CNs?
V/VI/VII/VIII (Pon pons - 5,6,7,8)
Medula comprised of which CNs
CN IX/X/XI/XII
Midbrain holds which 2 important nuclei and which 2 important tracts?
Oculomotor III nucleus and n
red nucleus
substantia nigra
Cerebral peduncle (Corticospinal tract, corticobulbar)
Pons holds which important structures?
4 Nuclei
5 tracts
2 structures
Nuclei: Mesencephalic (CN 5), Main sensory (CN 5) Motor nucleus (CN5), Pontine nuclei
Tracts: MLF, Spinothalamic, trigeminal lemniscus, medial lemniscus, corticospinal (also CN 5)
Structures: Superior cerebellar peduncle, Middle cerebellar peduncle
Medulla houses which important structures?
6 nuclei
5 tracts
4 structures
Nuclei: Hypoglossal Nucleus, Dorsal Motor Nucleus (CN10), Vestibular Nuclei, Nucleus solitarius, Spinal nucleus, Nucleus ambiguous
tracts: spinal tract (CN5), spinocerebellar tract, spinothalamic tract, corticospinal tract Medial lemniscus
Strctures: CN10, inferior cerebellar peduncle, inferior olive, CN 12
autonomic structures of the medulla oblongata
4
- reticular formation
- cardiovascular centers
- Respiratory center
- solitary nucleus - taste information from anterior 2/3 (facial) and posterior 1/3 (glossopharen), and vagus n (epiglotis); chemoreceptors from carotid and aortic bodies via vagus n.
– input from 7, 9, 10
3 relay centers of the medulla oblongata
- olivary nucleus
- Nucleus cuneatus
- Nucleus gracilis
reticular formation
Caudal Pons/medulla
functions (7)
- respiratory center - solitary nuc
- pacemaker for respirations - boetzinger complex
- project to LMN C3-5 and upper thoracic
- Control of HR and BP
- Motor systems from 4 tracts (reticulospinal, rubrospinal, tectospinal, vestibulospinal
- abnormal flexor/extensor posturing, CN reflexes
- coughing, hiccuping, sneezing, yawning, shivering, gagging, vomiting, swallowing laughing crying.
Ascending reticular system:
Activating system
4 functions
Ascending Reticular Activating System ● Rostral: mesencephalon & upper pons ● With projections to Thalamus/Hypothalamus, Basal Forbrain (Relays to Cortex) ● Alertness/ Attention/ Consciousness
● Glutamate?
Diencephalon comprised of 3 things
Thalamus
● Hypothalamus
● Pituitary Gland
Thalamus: 4 factors
Major Sensory Relay Station
Motor Input Relay Station (Cerebellum, Basal Ganglia)
Limbic Input Relay Station
Involved in Behavioral Arousal and sleep-wake cycle
Medial Nuclear Group
Lateral Nuclear Group
Anterior Nuclear Group
Internal Medullary Lamina
Relay nuclei of the thalamus do what? (4)
Relay Nuclei
Receive Input from numerous Pathways
●(Inner ear, Retina, Visual Cortex, Sensory
Pathways, Motor from Cerebellum & Basa Ganglia,
Premotor Cortex, Prefrontal Cortex)
●Project to the Cortex
●Screening/ Sorting/Preprocessing
●Behavioral Arousal, Sleep-wake cycle
Underneath thalamus is the 3rd ventricle
- link between:
- ______ involved in homeostasis (5 things)
- _____ control
- _____ system (emotional influence on autonomic and homeostatic pathways)
Underneath Thalamus/ Floor of Third
Ventricle
● Link between the Neural and Endocrine Systems
● Hypothalamus involved in Homeostasis (Hunger, Thirst,
Sexual Desire,Sleep-wake cycle, Thermoregulation)
● Autonomic control (Preganglionic in brain stem, spinal
cord)
● Limbic System (Emotional influence on autonomic and
homeostatic pathways)
Describe anatomy of pituitary and hormones secreted
- Anterior Pituitary
● regulates endocrine system
● -ACTH, GH, Prolactin, TSH, LH, FSH
● - Posterior Pituitary
● Oxytocin
● Vasopressin
What 7 things make up BG?
Insula ● Claustrum ● Nucleus Caudatus ● Globus Pallidus ● Putamen ● Subthalamic Nucleus ● Substantia Nigra
Basal ganglia function:
Inputs
Inputs From Entire Cerebral Cortex Most excitatory Neurotransmitter: Glutamate Most Important: Striatum
From Substantia Nigra/ Pars compacta Excitatory & Inhibitory Neurotransmitter: Dopamine Most Important to Striatum
Basal Ganglia output
Output ● From Globus Pallidus & Substantia Nigra ● Inhibitory: GABA ● Mainly to Thalamus – Thalamus projects to Cortex ● Reticular formation ● Tectospinal tracts ● Corticospinal tract
General motor control occurs in \_\_\_\_\_. Input: Relay in: Output: Critical for:
General Motor Control- Putamen
- Input: Somatosensory Cortex, primary Motor Cortex, Premotor Cortex
- Relay in Thalamus
- Output: Supplementary Motor Area, Premotor Cortex, Primary Motor Cortex
- Critical for Motor Planning &Motor Execution as well as sensory-motor integration
BG cognitive processes for frontal lobe occur in: Input: Relay: Output: Involived in (3) Formation of:
Cognitive process Frontal Lobe- Head of Caudate
- Input: Posterior Parietal Cortex; Premotor cortex
- Relay: Thalamus
- Output: Prefrontal Cortex
- Involved in Learning, Adaptation & Adjustment,
- Formation of new Behavioral Responses
Eye movement regarding BG occurs in ______
- Input:
- Relay in:
- Output:
Eye Movement - Caudate
● Input: Posterior Parietal Cortex,Prefrontal Cortex
● Relay in Thalamus
● Output:Frontal Eye Fields, supplementary eye fields
Emotion relayed in:
Input
Relay
Output
Emotion-Putamen, Caudate
● Input: Temporal Cortex, Hippocampus, Amygdala
● Relay in Thalamus
● Output: Anterior Cingulate, Orbital frontal Cortex
Name the movement dysorders associated with BG: (5)
● Movement Disorders/ Dyskinesias ● Dystonia ● Athetosis ● Chorea ● Parkinson's
Be able to label: Premotor cortex Primary motor cortex (pre-central) Primary somatosensory cortex (post-central) Brocas area Wernickes area Primary auditory cortex Primary visual cortex
picture in lecture
premotor, primary motor (gyrus), primary somatosensory
Broca under premotor, wernicke, Primary auditory anterior to wernicke
visual - occipital
Dominant hemi often which hemi?
Responsible for: (4)
● Left (95% RHD, 60-70% LHD) ● Language Processing ● Praxis ● Step-by-Step Formulation & Execution of Motor Tasks ● Sequential/ Analytical calculating Skills
Non-dominant hemi associated with (6)
Nonverbal Functions ● Complex visual-spatial skills ● Constructional Abilities ● Prosody- expressive & receptive ● Attention ● Personality change
Frontal lobe executive function:
Restraint
● Judgement, Concentration, Inhibiting inappropriate response, delaying gratification
● Initiative
● Spontaneity, Curiosity, Motivation, Creativity, Mental
Flexibility
● Order
● Abstract Reasoning, Working Memory, Perspective,
Insight, Organization
Dorsolateral lesion:
Abulia (passive, delayed responses, little
spontaneous activity)
Orbitofrontal lesion
Disinhibition,Witzelsucht, Impulsivity
Parietal lobe higher function (2)
Integration of Sensory Information
Visospatial Processing
Occipital lobe higher function (1)
Visual Processing
Temporal lobe higher function (5)
Primary auditory Cortex
● Auditory Processing including comprehension, naming, verbal memory
● Visual object perception and recognition, visual processing (faces, scenes)
● Declarative Memory (Facts/ Knowledge)
● Long-term memory
Anterior temporal lobe function (3)
- Impairment of learning and retention of verbal material
- Right anterior temporal lobe damage: impairs recognition and recall of visual and auditory patterns
- Disinhibited social behavior
Where is deep brain stimulator placed for parkinsons?
globus pallidus, subthalamic nuclei